AAN 2016

Everolimus Effective in Reducing Seizures in Tuberous Sclerosis Complex

Everolimus Effective in Reducing Seizures in Tuberous Sclerosis Complex

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The drug, which is indicated to treat certain types of cancer, is effective at reducing seizures in TSC when used as adjunctive therapy.

Elevated Salt and Mineral Intake Not Linked to Higher Risk of Multiple Sclerosis

Elevated Salt and Mineral Intake Not Linked to Higher Risk of Multiple Sclerosis

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The role of sodium and other minerals as risk factors for MS was previously unclear.

Adjunctive Treatment Improves Control of Partial Seizures

Adjunctive Treatment Improves Control of Partial Seizures

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Concomitant AED and perampanel treatment was well tolerated by patients with secondarily generalized seizures.

Ocrelizumab Promotes No Evidence of Disease Activity in Multiple Sclerosis

Ocrelizumab Promotes No Evidence of Disease Activity in Multiple Sclerosis

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Treatment with the biannual injection consistently resulted in greater achievement of NEDA compared to standard care.

Setting Expectations for DBS in PD: Key to Success

Setting Expectations for DBS in PD: Key to Success

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Setting reasonable expectations can enhance patient satisfaction and improve overall treatment outcomes.

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

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Reading and playing games may help reduce MCI risk in non-APOE-ε4 carriers.

Smoking Cessation Decelerates Brain Volume Loss in Multiple Sclerosis

Smoking Cessation Decelerates Brain Volume Loss in Multiple Sclerosis

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Smoking has been linked to advanced brain atrophy in individuals with multiple sclerosis.

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

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Researchers have uncovered a positive synergistic interaction between Alzheimer's pathology and neuropsychiatric symptoms.

Misconceptions About Epilepsy Centers Prevent Access to Care for Refractory Epilepsy

Misconceptions About Epilepsy Centers Prevent Access to Care for Refractory Epilepsy

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Widespread misconceptions about epilepsy center services prevent many patients from getting the care they need and deserve.

Personal Health Records Encourage Engagement, Improve Readmission Rates in Stroke

Personal Health Records Encourage Engagement, Improve Readmission Rates in Stroke

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Personal health records have the potential to empower patients as they transition from hospital to home.

Rates of Epilepsy in Autism Quantified

Rates of Epilepsy in Autism Quantified

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Children with autism are known to have increased rates of epilepsy; however, many prior studies aimed to quantify these rates are small.

Stem Cell-Derived Therapy Shows Promise in Progressive Multiple Sclerosis

Stem Cell-Derived Therapy Shows Promise in Progressive Multiple Sclerosis

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Intrathecal dosing of neural progenitors appears to be safe and well tolerated in patients with progressive multiple sclerosis.

Study Shows Potential of Novel Compound to Treat Multiple Sclerosis

Study Shows Potential of Novel Compound to Treat Multiple Sclerosis

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Investigational agent has the potential to repair damaged myelin sheath and restore function in patients with secondary-progressive multiple sclerosis.

Botox May Be Effective Treatment for Lower Limb Spasticity After Stroke

Botox May Be Effective Treatment for Lower Limb Spasticity After Stroke

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While Botox is approved by the US FDA for the treatment of poststroke upper limb spasticity, its efficacy in poststroke lower limb spasticity is still being investigated.

Updated Treatment Guidelines for the Use of Botulinum Toxin in Spasticity, Headache

Updated Treatment Guidelines for the Use of Botulinum Toxin in Spasticity, Headache

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Treatment of chronic, but not episodic migraine with botulinum toxin has been added to the treatment guidelines.

Antioxidant May Offer Neuroprotection in Multiple Sclerosis

Antioxidant May Offer Neuroprotection in Multiple Sclerosis

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Lipoic acid, an easily available and inexpensive oral antioxidant acid, has been proposed as a therapeutic approach in multiple sclerosis.

Conception, Pregnancy Outcomes in Women With Epilepsy Comparable to Healthy Peers

Conception, Pregnancy Outcomes in Women With Epilepsy Comparable to Healthy Peers

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The findings should help reassure both patients and clinicians during the family planning process.

Responsive Stimulation May Be Viable Treatment for Medically Intractable Mesial Temporal Lobe Epilepsy

Responsive Stimulation May Be Viable Treatment for Medically Intractable Mesial Temporal Lobe Epilepsy

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While temporal lobectomy is the best treatment for many with medically intractable MTLE, responsive stimulation provides a treatment alternative..

Multiple Sclerosis Relapses Common During 20-Year Period

Multiple Sclerosis Relapses Common During 20-Year Period

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Patients with MS were likely to experience relapses for the first time or relapse continuation between the ages of 27 and 47 years.

Link Observed Between GBA Mutations and REM Sleep Behavior Disorder

Link Observed Between GBA Mutations and REM Sleep Behavior Disorder

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Glucocerebrosidase gene mutation has been found to be strongly associated with REM sleep behavior disorder.

Functional MRI Connectivity Alterations Associated With Cognitive Dysfunction in MS

Functional MRI Connectivity Alterations Associated With Cognitive Dysfunction in MS

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Investigators aimed to quantify functional connectivity differences in patients with MS and to determine the association between these alterations and cognitive performance.

Altered Functional Network May Cause Cognitive Impairment in Temporal Lobe Epilepsy Patients

Altered Functional Network May Cause Cognitive Impairment in Temporal Lobe Epilepsy Patients

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An altered functional network involving the ipsilateral and contralateral hippocampal areas was associated with cognitive impairment in patients with temporal lobe epilepsy.

Nurse-Activated Stroke Codes Improve Process, Clinical Outcomes

Nurse-Activated Stroke Codes Improve Process, Clinical Outcomes

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A nurse-driven stroke evaluation algorithm improved patient triage and treatment utilization.

Elevated  Levels of Furan Fatty Acid Metabolite in MS

Elevated Levels of Furan Fatty Acid Metabolite in MS

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Elevated levels of CMPF, which has been linked to beta cell dysfunction in diabetes and thyroid disorders, have been identified in patients with MS.

Adaptive Training Improves Cognitive Function in Multiple Sclerosis

Adaptive Training Improves Cognitive Function in Multiple Sclerosis

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Adaptive programs allow for real-time adjustment to a user's level of performance.

Shared Decision Making for Successful Patient Engagement

Shared Decision Making for Successful Patient Engagement

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Effective shared decision making promotes collaboration among the care team and can improve patient outcomes.

Monoclonal Antibody Efficacious for Treatment of Migraines

Monoclonal Antibody Efficacious for Treatment of Migraines

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Phase 2 results show anti-CGRP receptor monoclonal antibody effective for the prevention of episodic migraine.

MRI Features Associated With Clinical Symptoms in Mild Traumatic Brain Injury

MRI Features Associated With Clinical Symptoms in Mild Traumatic Brain Injury

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Investigators aimed to predict outcomes in patients with mild traumatic brain injury by identifying MRI features that are associated with clinical symptoms.

Sex Change From Male to Female May Increase MS Risk

Sex Change From Male to Female May Increase MS Risk

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Researchers hypothesized that an altered balance of sex hormones in men with gender identity disorder would increase the risk of MS.

Recommended Reversal Time of Vitamin K Antagonists Identified for ICH

Recommended Reversal Time of Vitamin K Antagonists Identified for ICH

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As ICH volume is known to increase within the first 3 hours following intracerebral hemorrhage, timely reversal is vital for patients on anticoagulation.

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