AES 2017

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

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Clobazam is currently FDA-approved for the treatment of seizures associated with Lennox-Gastaut syndrome in children 2 years and older.

Foramen Ovale EEG Identifies Epileptogenic Zone in Mesial Temporal Lobe Epilepsy

Foramen Ovale EEG Identifies Epileptogenic Zone in Mesial Temporal Lobe Epilepsy

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The diagnostic tool may be especially useful in cases of nonlesional mesial temporal lobe epilepsy.

Alternative Therapies Improve Seizure Frequency, Quality of Life in Treatment-Refractory Epilepsy

Alternative Therapies Improve Seizure Frequency, Quality of Life in Treatment-Refractory Epilepsy

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Patients with refractory epilepsy who fail to benefit from 2 or more AEDs should be referred to alternative therapies.

Brainstem Damage in Epilepsy May Be Biomarker for Increased SUDEP Risk

Brainstem Damage in Epilepsy May Be Biomarker for Increased SUDEP Risk

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Patients who died from suspected SUDEP had extensive damage to areas of the mid-brain and brainstem that control autonomic function.

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

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Researchers compared outcomes between patients treated with continuous infusion or repeated doses of nonbenzodiazepine anti-seizure medication.

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

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The study was a post-hoc analysis of responders who were on or off concomitant clobazam.

Signficant Risk of Seizures After Stroke Treatment With Reperfusion Therapies

Signficant Risk of Seizures After Stroke Treatment With Reperfusion Therapies

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Patients undergoing treatment for ischemic stroke are at greater risk for seizure development.

Seizure Frequency Predicts Neuropsychiatric Outcomes in BECTS

Seizure Frequency Predicts Neuropsychiatric Outcomes in BECTS

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Researchers examined whether there are clinical features or treatments associated with neuropsychiatric outcomes in BECTS.

Bone Mineral Density Loss Prevention Needed in Epilepsy

Bone Mineral Density Loss Prevention Needed in Epilepsy

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Treatment algorithms are needed for patients with epilepsy who present with evidence of bone loss.

Positive Airway Pressure Improves Seizure Control in Epilepsy and Obstructive Sleep Apnea

Positive Airway Pressure Improves Seizure Control in Epilepsy and Obstructive Sleep Apnea

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Treatment with positive airway pressure may help retain or improve seizure control in patients with epilepsy and obstructive sleep apnea.

Early Surgical Intervention Improves Likelihood of Good Cognitive Outcomes in Epilepsy

Early Surgical Intervention Improves Likelihood of Good Cognitive Outcomes in Epilepsy

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Preoperative cognitive function is a central component of predicting cognitive outcomes after resective epilepsy surgery.

Objective Score Identifies Non-Epileptic Psychogenic Seizures Linked to Abuse, TBI

Objective Score Identifies Non-Epileptic Psychogenic Seizures Linked to Abuse, TBI

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This objective score may have the potential to be an early outpatient screening tool for identifying PNES.

Association Between Seizure Onset and Year of Menarche in Women With Epilepsy

Association Between Seizure Onset and Year of Menarche in Women With Epilepsy

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Researchers suggest the combined effects of adrenarche and menarche may play a role in the relationship.

Low-dose Levetiracetam Associated With High Treatment Success in Childhood Absence Epilepsy

Low-dose Levetiracetam Associated With High Treatment Success in Childhood Absence Epilepsy

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The investigators advised that patients who require continued-dose escalation should be transitioned to a first-line therapy for absence epilepsy.

SUDEP Uncommon in Children With Epilepsy Without Cognitive Deficit

SUDEP Uncommon in Children With Epilepsy Without Cognitive Deficit

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Compared with previous research, the current study found little risk for SUDEP in children without cognitive deficit.

Duration of Refractory Status Epilepticus May Predict Neurologic Deficits

Duration of Refractory Status Epilepticus May Predict Neurologic Deficits

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Approximately one-third of pediatric patients with refractory convulsive status epilepticus develop neurologic deficits.

Minority Women With Epilepsy Have Higher Rates of Unplanned Pregnancies vs Women Without Epilepsy

Minority Women With Epilepsy Have Higher Rates of Unplanned Pregnancies vs Women Without Epilepsy

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Although unplanned, women with epilepsy were very likely to take required prenatal vitamins.

Add-on Cannabidiol Generally Safe for Treatment-Resistant Epilepsy, Dravet, Lennox-Gastaut Syndromes

Add-on Cannabidiol Generally Safe for Treatment-Resistant Epilepsy, Dravet, Lennox-Gastaut Syndromes

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Adverse reactions in the CBD group included decreased appetite, diarrhea, fatigue, lethargy, nasopharyngitis, pneumonia, pyrexia, rash, and somnolence.

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