Alzheimer's Disease and Dementia

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

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Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.

Concussions May Accelerate Alzheimer's in At-Risk Populations

Concussions May Accelerate Alzheimer's in At-Risk Populations

In people who are genetically at-risk for Alzheimer's, concussions appear to accelerate brain changes associated with the disease.

 Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

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Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

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Hormone therapy may reduce risk for death from vascular dementia in older women.

Alzheimer's-Related Amyloid Found in the Heart

Alzheimer's-Related Amyloid Found in the Heart

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Amyloid beta protein accumulation was present in the hearts of patients with Alzheimer's disease.

Treatment Guidance for Sleep Disorders in Dementia Lacking

Treatment Guidance for Sleep Disorders in Dementia Lacking

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There is a clear lack of evidence in the pharmacologic guidance of sleep problems in dementia.

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Patients with Alzheimer's disease tended to have increased thickness in the wall of their left ventricle.

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

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The present findings, in combination with those from prior observational research, provide a solid rationale for further randomized trials.

No Benefit for Occupational Therapy in Alzheimer's Disease

No Benefit for Occupational Therapy in Alzheimer's Disease

There seems to be no effect on everyday functioning.

Solanezumab Fails Primary End Point in Alzheimer's Trial

Solanezumab Fails Primary End Point in Alzheimer's Trial

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Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.

Rates of Dementia Decreasing In the United States

Rates of Dementia Decreasing In the United States

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Higher levels of education and better management of cardiovascular risk factors may have contributed to this improvement.

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

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Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.

Can Loneliness Predict Early Alzheimer's Disease?

Can Loneliness Predict Early Alzheimer's Disease?

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Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.

Orthostatic Hypotension Linked to Increased Risk of Dementia

Orthostatic Hypotension Linked to Increased Risk of Dementia

Sudden blood pressure drops may lead to hypoxia, which has detrimental effects on brain tissue.

When It's Not Alzheimer's: The Differential Diagnosis of Frontotemporal Lobar Degeneration

When It's Not Alzheimer's: The Differential Diagnosis of Frontotemporal Lobar Degeneration

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Neuroimaging and if necessary, genetic testing, can help to confirm an FTD diagnosis.

Thyroid Hormone Levels Impact Dementia Risk

Thyroid Hormone Levels Impact Dementia Risk

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Researchers hypothesize that thyroid function affects dementia risk through nonvascular pathways.

Young Blood Plasma Improves Alzheimer's Biomarkers in APP Mice

Young Blood Plasma Improves Alzheimer's Biomarkers in APP Mice

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Previous studies have investigated the effects of exposing aged mice to the blood of young mice through heterochronic parabiosis or via injection of young blood plasma.

Alcohol and Alzheimer's: What's the Connection?

Alcohol and Alzheimer's: What's the Connection?

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An update on the latest research developments examining the connection between alcohol consumption and Alzheimer's disease.

SNAP Not Linked to Early Alzheimer's Disease

SNAP Not Linked to Early Alzheimer's Disease

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Suspected non-Alzheimer disease pathophysiology (SNAP) does not appear to be linked to early Alzheimer disease processes.

Physical Function Measures May Help Predict Dementia

Physical Function Measures May Help Predict Dementia

Weaker handgrip was also associated with an elevated risk of stroke.

Deep Brain Stimulation May Have Some Benefit for Alzheimer's Patients

Deep Brain Stimulation May Have Some Benefit for Alzheimer's Patients

The treatment was generally safe, but benefit varied across age groups.

Checklist May Help Identify Behavior Problems in Elderly

Checklist May Help Identify Behavior Problems in Elderly

The checklist may help identify those in the early stages of neurodegenerative disease.

Vascular Intervention Does Not Appear to Affect Dementia Incidence

Vascular Intervention Does Not Appear to Affect Dementia Incidence

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Cases of all-cause dementia and Alzheimer's did not significantly differ between study groups.

When It's Not Alzheimer's: The Differential Diagnosis of Dementia With Lewy Bodies

When It's Not Alzheimer's: The Differential Diagnosis of Dementia With Lewy Bodies

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According to a 2010 report based on a survey of caregivers of people with DLB, 78% of cases were initially misdiagnosed.

PET Imaging Useful for Identifying Alzheimer's Disease Stage

PET Imaging Useful for Identifying Alzheimer's Disease Stage

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Findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.

Non-Pharmacological Approach Feasible in Elderly With Behavior, Psychological Problems

Non-Pharmacological Approach Feasible in Elderly With Behavior, Psychological Problems

It will take a lot of work to change the prescribing culture in adult care.

Effects of APOE ε4 on Brain Development Apparent in Childhood

Effects of APOE ε4 on Brain Development Apparent in Childhood

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Those with ε4 homozygosity have the highest odds ratio of the earliest Alzheimer's onset.

CSF Biomarkers Aid in Psychiatric, Cognitive Disorders Differential Diagnosis

CSF Biomarkers Aid in Psychiatric, Cognitive Disorders Differential Diagnosis

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This is the first study to examine the role of CSF biomarkers in the diagnosis of patients with cognitive symptoms and psychiatric disorders in routine daily clinical practice.

Genetic Variant Risk Score Associated With Early Markers of Alzheimer's Disease

Genetic Variant Risk Score Associated With Early Markers of Alzheimer's Disease

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PGRS was also associated with hippocampal volume in younger participants.

Microbleed Volume Influences Risk of Cognitive Decline, Dementia

Microbleed Volume Influences Risk of Cognitive Decline, Dementia

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Microbleeds were prevalent in 15.3% of the cohort.

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