Alzheimer’s Disease And Dementia

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

Solanezumab Every 4 Weeks Does Not Significantly Affect Cognitive Decline in Alzheimer Disease

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The 400 mg solanezumab dose used in this study may not have been sufficient enough to provide clinically meaningful effects in these patients.

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

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Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

Increased Midlife Triglyceride Levels Predictive of Alzheimer Disease Pathology

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If confirmed in future studies, high triglycerides may present a modifiable risk factor for Alzheimer disease.

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

Proton Pump Inhibitor Use Not Associated With Increased Dementia Risk

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A population-based cohort study evaluated whether proton pump inhibitor use was associated with an increased risk for dementia.

When and How to Approach Driving Cessation in Patients With Dementia

When and How to Approach Driving Cessation in Patients With Dementia

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The responsibility for discussing cessation of driving in patients with mild cognitive impairment or dementia often rests on the clinician, who may have little preparation for this difficult conversation.

Language Deficits and EEG Changes Predict Conversion From MCI to Alzheimer Disease

Language Deficits and EEG Changes Predict Conversion From MCI to Alzheimer Disease

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Participants with MCI who developed Alzheimer disease at 3 years were more likely to demonstrate diminished theta increase on EEG compared with patients who did not develop the disease.

Alzheimer Disease Drug Candidate Granted Fast Track Status

Alzheimer Disease Drug Candidate Granted Fast Track Status

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The FDA has granted Fast Track designation to ALZ-801 for the treatment of Alzheimer disease.

Alzheimer Disease Linked to High Cumulative Doses of Zolpidem in Elderly

Alzheimer Disease Linked to High Cumulative Doses of Zolpidem in Elderly

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Zolpidem has been associated with memory loss and decline in cognitive function.

Androgen Deprivation Therapy Does Not Increase Dementia or Alzheimer Risk

Androgen Deprivation Therapy Does Not Increase Dementia or Alzheimer Risk

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Previous research has suggested an association between androgen deprivation therapy and risk for Alzheimer dementia.

Dementia Risk Significantly Increased for Individuals Born in High Stroke Mortality States

Dementia Risk Significantly Increased for Individuals Born in High Stroke Mortality States

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Birthplace is a significant risk factor for dementia, even after adjusting for educational levels, race, and life-course vascular risk factors.

Can Proton Pump Inhibitors Raise Dementia Risk?

Can Proton Pump Inhibitors Raise Dementia Risk?

Those who used PPIs were also more likely to use anticholinergic medicines that have been linked to cognitive difficulties

Degree of Amyloid Deposition Helps Predict Cognitive Decline

Degree of Amyloid Deposition Helps Predict Cognitive Decline

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The main differentiating factor was the presence of the APOE ε4 allele.

Growing Old Without Alzheimer's Pathology: What's the Secret?

Growing Old Without Alzheimer's Pathology: What's the Secret?

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The main differentiating factor was the presence of the APOE ε4 allele.

Discontinuation of Alzheimer's Treatment Linked to Adverse Events

Discontinuation of Alzheimer's Treatment Linked to Adverse Events

Adverse events were related to over 73% of medication discontinuations.

Serum Cytokine Levels May Correlate With Cognitive Dysfunction in Alzheimer's Disease

Serum Cytokine Levels May Correlate With Cognitive Dysfunction in Alzheimer's Disease

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Patients with Alzheimer's disease may have higher serum IL-6 levels than subjects with mild cognitive impairment and healthy controls.

Alzheimer's Mortality Increasing, But So Is At-Home Care

Alzheimer's Mortality Increasing, But So Is At-Home Care

More patients are dying at home as opposed to in nursing home facilities, suggesting increased support for caregivers is necessary.

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

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Sleep behavior and irritability may be early noncognitive symptoms of Alzheimer's dementia.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

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A history of 2 or more vascular risk factors assessed at baseline in the ARIC study was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

New Gene Linked to Accelerated Decline in Alzheimer's

New Gene Linked to Accelerated Decline in Alzheimer's

Participants with the Met allele lost memory and cognitive skills more rapidly than those without the gene mutation.

Alzheimer's Not Linked to a History of Psychiatric Disorders

Alzheimer's Not Linked to a History of Psychiatric Disorders

Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

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Clinicians must keep this potentially increased risk in mind when prescribing long-term use of a specific anticholinergic drug to patients with DM suffering from OAB.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

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The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

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Benzodiazepines increase risk for pneumonia-associated hospitalization, mortality in patients with Alzheimer disease.

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

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Non-demented elderly patients experiencing excessive daytime sleepiness may be at increased risk for β-amyloid accumulation.

Alzheimer's Related Gene May Induce Psychosis in Females

Alzheimer's Related Gene May Induce Psychosis in Females

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Females with Alzheimer's disease, the APOE4 gene, and comorbid Lewy bodies were more likely to experience psychosis.

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

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No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.

Dementia Incidence Not Affected by Antioxidant Supplements

Dementia Incidence Not Affected by Antioxidant Supplements

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After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

A behavioral interventions program for Alzheimer's patient caregivers did not increase health costs.

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