Alzheimer’s Disease And Dementia

Can Proton Pump Inhibitors Raise Dementia Risk?

Can Proton Pump Inhibitors Raise Dementia Risk?

Those who used PPIs were also more likely to use anticholinergic medicines that have been linked to cognitive difficulties

Degree of Amyloid Deposition Helps Predict Cognitive Decline

Degree of Amyloid Deposition Helps Predict Cognitive Decline

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The main differentiating factor was the presence of the APOE ε4 allele.

Growing Old Without Alzheimer's Pathology: What's the Secret?

Growing Old Without Alzheimer's Pathology: What's the Secret?

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The main differentiating factor was the presence of the APOE ε4 allele.

Discontinuation of Alzheimer's Treatment Linked to Adverse Events

Discontinuation of Alzheimer's Treatment Linked to Adverse Events

Adverse events were related to over 73% of medication discontinuations.

Serum Cytokine Levels May Correlate With Cognitive Dysfunction in Alzheimer's Disease

Serum Cytokine Levels May Correlate With Cognitive Dysfunction in Alzheimer's Disease

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Patients with Alzheimer's disease may have higher serum IL-6 levels than subjects with mild cognitive impairment and healthy controls.

Alzheimer's Mortality Increasing, But So Is At-Home Care

Alzheimer's Mortality Increasing, But So Is At-Home Care

More patients are dying at home as opposed to in nursing home facilities, suggesting increased support for caregivers is necessary.

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

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Sleep behavior and irritability may be early noncognitive symptoms of Alzheimer's dementia.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

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A history of 2 or more vascular risk factors assessed at baseline in the ARIC study was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

New Gene Linked to Accelerated Decline in Alzheimer's

New Gene Linked to Accelerated Decline in Alzheimer's

Participants with the Met allele lost memory and cognitive skills more rapidly than those without the gene mutation.

Alzheimer's Not Linked to a History of Psychiatric Disorders

Alzheimer's Not Linked to a History of Psychiatric Disorders

Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

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Clinicians must keep this potentially increased risk in mind when prescribing long-term use of a specific anticholinergic drug to patients with DM suffering from OAB.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

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The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

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Benzodiazepines increase risk for pneumonia-associated hospitalization, mortality in patients with Alzheimer disease.

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

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Non-demented elderly patients experiencing excessive daytime sleepiness may be at increased risk for β-amyloid accumulation.

Alzheimer's Related Gene May Induce Psychosis in Females

Alzheimer's Related Gene May Induce Psychosis in Females

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Females with Alzheimer's disease, the APOE4 gene, and comorbid Lewy bodies were more likely to experience psychosis.

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

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No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.

Dementia Incidence Not Affected by Antioxidant Supplements

Dementia Incidence Not Affected by Antioxidant Supplements

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After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

A behavioral interventions program for Alzheimer's patient caregivers did not increase health costs.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

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Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

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Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.

Concussions May Accelerate Alzheimer's in At-Risk Populations

Concussions May Accelerate Alzheimer's in At-Risk Populations

In people who are genetically at-risk for Alzheimer's, concussions appear to accelerate brain changes associated with the disease.

 Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

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Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

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Hormone therapy may reduce risk for death from vascular dementia in older women.

Alzheimer's-Related Amyloid Found in the Heart

Alzheimer's-Related Amyloid Found in the Heart

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Amyloid beta protein accumulation was present in the hearts of patients with Alzheimer's disease.

Treatment Guidance for Sleep Disorders in Dementia Lacking

Treatment Guidance for Sleep Disorders in Dementia Lacking

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There is a clear lack of evidence in the pharmacologic guidance of sleep problems in dementia.

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Patients with Alzheimer's disease tended to have increased thickness in the wall of their left ventricle.

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