Alzheimer’s Disease And Dementia

Alzheimer's Related Gene May Induce Psychosis in Females

Alzheimer's Related Gene May Induce Psychosis in Females

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Females with Alzheimer's disease, the APOE4 gene, and comorbid Lewy bodies were more likely to experience psychosis.

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

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No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.

Dementia Incidence Not Affected by Antioxidant Supplements

Dementia Incidence Not Affected by Antioxidant Supplements

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After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

Alzheimer's Caregiver Coping Program Does Not Increase Health Care Costs

A behavioral interventions program for Alzheimer's patient caregivers did not increase health costs.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

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Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

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Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.

Concussions May Accelerate Alzheimer's in At-Risk Populations

Concussions May Accelerate Alzheimer's in At-Risk Populations

In people who are genetically at-risk for Alzheimer's, concussions appear to accelerate brain changes associated with the disease.

 Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

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Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

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Hormone therapy may reduce risk for death from vascular dementia in older women.

Alzheimer's-Related Amyloid Found in the Heart

Alzheimer's-Related Amyloid Found in the Heart

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Amyloid beta protein accumulation was present in the hearts of patients with Alzheimer's disease.

Treatment Guidance for Sleep Disorders in Dementia Lacking

Treatment Guidance for Sleep Disorders in Dementia Lacking

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There is a clear lack of evidence in the pharmacologic guidance of sleep problems in dementia.

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Patients with Alzheimer's disease tended to have increased thickness in the wall of their left ventricle.

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

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The present findings, in combination with those from prior observational research, provide a solid rationale for further randomized trials.

No Benefit for Occupational Therapy in Alzheimer's Disease

No Benefit for Occupational Therapy in Alzheimer's Disease

There seems to be no effect on everyday functioning.

Solanezumab Fails Primary End Point in Alzheimer's Trial

Solanezumab Fails Primary End Point in Alzheimer's Trial

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Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.

Rates of Dementia Decreasing In the United States

Rates of Dementia Decreasing In the United States

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Higher levels of education and better management of cardiovascular risk factors may have contributed to this improvement.

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

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Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.

Can Loneliness Predict Early Alzheimer's Disease?

Can Loneliness Predict Early Alzheimer's Disease?

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Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.

Challenges Remain in Understanding Role of Hypertension in Cognition

Challenges Remain in Understanding Role of Hypertension in Cognition

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A committee from the American Heart Association failed to make specific clinical recommendations for the management of hypertension related to cognitive impairment.

Orthostatic Hypotension Linked to Increased Risk of Dementia

Orthostatic Hypotension Linked to Increased Risk of Dementia

Sudden blood pressure drops may lead to hypoxia, which has detrimental effects on brain tissue.

When It's Not Alzheimer's: The Differential Diagnosis of Frontotemporal Lobar Degeneration

When It's Not Alzheimer's: The Differential Diagnosis of Frontotemporal Lobar Degeneration

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Neuroimaging and if necessary, genetic testing, can help to confirm an FTD diagnosis.

Thyroid Hormone Levels Impact Dementia Risk

Thyroid Hormone Levels Impact Dementia Risk

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Researchers hypothesize that thyroid function affects dementia risk through nonvascular pathways.

Young Blood Plasma Improves Alzheimer's Biomarkers in APP Mice

Young Blood Plasma Improves Alzheimer's Biomarkers in APP Mice

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Previous studies have investigated the effects of exposing aged mice to the blood of young mice through heterochronic parabiosis or via injection of young blood plasma.

Alcohol and Alzheimer's: What's the Connection?

Alcohol and Alzheimer's: What's the Connection?

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An update on the latest research developments examining the connection between alcohol consumption and Alzheimer's disease.

SNAP Not Linked to Early Alzheimer's Disease

SNAP Not Linked to Early Alzheimer's Disease

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Suspected non-Alzheimer disease pathophysiology (SNAP) does not appear to be linked to early Alzheimer disease processes.

Physical Function Measures May Help Predict Dementia

Physical Function Measures May Help Predict Dementia

Weaker handgrip was also associated with an elevated risk of stroke.

Deep Brain Stimulation May Have Some Benefit for Alzheimer's Patients

Deep Brain Stimulation May Have Some Benefit for Alzheimer's Patients

The treatment was generally safe, but benefit varied across age groups.

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