For community-dwelling older men, low serum sodium is associated with cognitive impairment and cognitive decline.
Solanezumab does not alter cognitive decline in patients with mild Alzheimer disease.
In older at-risk individuals, even APOE ε4 carriers, a multidomain lifestyle intervention seems to be beneficial.
Cognitive therapies may help reduce falls in order adults.
For patients with mild-to-moderate Alzheimer disease, the use of idalopirdine does not improve cognition.
Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive ImpairmentJanuary 15, 2018
A lower education level was associated with higher MCI prevalence in 8 of the class I studies.
Greater yearly declines in systolic and diastolic blood pressure were noted in individuals with subcortical microinfarcts.
Clinicians might benefit from standard guidelines on how to assess and refer patients with hearing loss.
Intake of nutrients in green leafy vegetables is linked to a slower cognitive decline.
Charts may help identify individuals who may benefit most from early interventions to help preserve cognition.
In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.
Throughout the life course, higher body mass index and obesity are linked to cognitive decline, brain atrophy, reduced white matter and integrity of the blood-brain barrier, and elevated risk for late-onset Alzheimer disease.
The ACB scale shows good dose-response relationships between anticholinergic burden and adverse outcomes for older adults.
An approximately 1-SD increase in SBP correlated with lower scores for 2 tests that assessed for brain damage, dementia, and task switching.
Although evidence of cognitive impairment in MSA is admittedly more limited than in Parkinson disease, it is now substantial enough to address modification of diagnostic criteria to include the potential for cognitive impairment at any stage of the disease.
Multiple biological factors may play a role when cognitive decline is observed in older health adults.
Cognitive dysfunction may be a sign of prodromal Parkinson disease.
Mechanisms including silent cerebral infarct, microemboli, microbleedings, and cerebral hypoperfusion may be responsible for the link between atrial fibrillation and cognitive decline.
SCD is associated with increased entorhinal cortical tau burden and β-amyloid burden in healthy older adults.
Individuals with prevalent dementia and any nursing home use had especially high 1-year mortality.
Cognitive dysfunction may be the result of lower intracerebral vasomotor reactivity which is linked to PHPT.
Older adults with sleep-disordered breathing have a 26% greater risk for developing cognitive impairment and a small risk for deteriorating executive function.
Previous reports have suggested that statins or the low levels of LDL cholesterol they promote may have an adverse impact on cognition.
Findings from this trial challenge current recommended systolic blood pressure targets for older adults.
There is no association between use of cardiovascular medication and cognitive impairment in older adults.
Visual dysfunction is associated with poor cognitive function in older adults.
Cognitive deficits can be caused by sleep-disordered breathing.
An increase in weight ≥5% was associated with lower cognitive scores.
Patients with the highest predictive scores faced a greater risk of developing cognitive impairment and dementia in the first 10 years after disease onset.
Many residents in nursing homes with cognitive impairments may be taking potentially inappropriate medications.
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