Epilepsy Headlines

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

The FDA-sponsored study sought to evaluate the bioequivalence of 2 generic forms of the popular epilepsy treatment lamotrigine.

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Changes in serum concentrations of other anti-epileptic drugs were not found to be significant.

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Those with uncomplicated epilepsy who were seizure-free for five years had social outcomes comparable to their siblings.

Zika Virus May Trigger Epilepsy in Infants

Zika Virus May Trigger Epilepsy in Infants

The finding isn't overly surprising since the types of brain abnormalities seen in Zika-affected newborns have been linked to seizures and epilepsy in the past.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.

New Guideline Tackles Sudden Unexpected Death in Epilepsy

New Guideline Tackles Sudden Unexpected Death in Epilepsy

A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.

Sepsis Associated With Long-term Seizure Risk

Sepsis Associated With Long-term Seizure Risk

Sepsis is associated with pathways that lead to permanent neurological sequelae.

Maternal BMI May Affect Epilepsy Risk in Offspring

Maternal BMI May Affect Epilepsy Risk in Offspring

Women with higher body mass index were associated with children with a greater epilepsy incidence.

Epilepsy Risk May Increase After Incident Depression

Epilepsy Risk May Increase After Incident Depression

Underlying pathophysiological mechanisms may connect depression and epilepsy.

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Lamotrigine and carbamazepine may represent safer treatment alternatives for girls and women who are or who might become pregnant.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

In people with Dravet syndrome, language impairments increase with age, suggesting that early intervention with targeted oral motor therapies may be helpful.

Epilepsy, Seizures Common Among Nursing Home Population

Epilepsy, Seizures Common Among Nursing Home Population

Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

There is as much as a 32% risk for vigabatrin-associated brain abnormalities in patients with infantile spasms.

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.

Cortical Excitability Tied to Duration and Degree of Seizure Control

Cortical Excitability Tied to Duration and Degree of Seizure Control

This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

A subset of epilepsy cases of unknown etiology may be secondary to the production of autoantibodies.

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