Epilepsy Headlines

Epilepsy Risk May Increase After Incident Depression

Epilepsy Risk May Increase After Incident Depression

Underlying pathophysiological mechanisms may connect depression and epilepsy.

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Lamotrigine and carbamazepine may represent safer treatment alternatives for girls and women who are or who might become pregnant.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

In people with Dravet syndrome, language impairments increase with age, suggesting that early intervention with targeted oral motor therapies may be helpful.

Epilepsy, Seizures Common Among Nursing Home Population

Epilepsy, Seizures Common Among Nursing Home Population

Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

There is as much as a 32% risk for vigabatrin-associated brain abnormalities in patients with infantile spasms.

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.

Cortical Excitability Tied to Duration and Degree of Seizure Control

Cortical Excitability Tied to Duration and Degree of Seizure Control

This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

A subset of epilepsy cases of unknown etiology may be secondary to the production of autoantibodies.

Epilepsy Treatment Often Delayed in Older Adults

Epilepsy Treatment Often Delayed in Older Adults

Despite recommendations, many patients in the cohort were prescribed older antiepileptic drugs.

Epilepsy Education Group Helps Patients Cope With Isolation, Anger

Epilepsy Education Group Helps Patients Cope With Isolation, Anger

Patients who participated in a group course with other people with epilepsy felt less isolated and more confident.

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

A diagnosis of maternal epilepsy alone was not associated with an increase in congenital malformations in offspring.

Quality Improvement Measures Improve Health Care Utilization in Epilepsy

Quality Improvement Measures Improve Health Care Utilization in Epilepsy

Quality improvement measures help to reduce emergency department visits, inpatient hospitalizations, and health care claims.

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.

Should EEG Periodic Discharges be Managed Similarly to Seizures?

Should EEG Periodic Discharges be Managed Similarly to Seizures?

Brain oxygenation may be compromised during periodic discharges, ultimately warranting treatment.

Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

Nearly 60% of patients had achieved seizure freedom at last follow-up, 10 to 21 years after surgery.

EEG Patterns in Critically Ill Point to Greater Risk of Seizures

EEG Patterns in Critically Ill Point to Greater Risk of Seizures

Careful monitoring of EEG patterns is a useful way to stratify seizure risk in critically ill patients.

First-Line Treatment With Carbamazepine in Neonatal Epilepsy

First-Line Treatment With Carbamazepine in Neonatal Epilepsy

The results confirm the effectiveness and safety of low-dose CBZ as a first-line agent for the treatment of neonatal seizures.

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