Epilepsy Headlines

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Fycompa Granted Priority Review for Pediatric Indications

Fycompa Granted Priority Review for Pediatric Indications

The sNDA included data from Study 311 (N=180), an ongoing, open-label, multicenter trial with an extension phase that evaluated the safety, tolerability, and exposure-efficacy relationship of Fycompa oral suspension as adjunctive therapy in children (4 to 11 years) with inadequately controlled POS or PGTC seizures.

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

Stroke Survivors Have Higher Risk for Subsequent Seizures Than General Population

At 8 years, the cumulative rate of any hospitalization or emergency department visit for seizure was higher among patients with stroke vs the general population.

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

Rates of Pregnancy, Live Births Similar Among Women With and Without Epilepsy

The results of this study should help reassure and encourage women with epilepsy without a prior diagnosis of infertility or an associated disorder who are seeking pregnancy.

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

Valproic Acid-Related Adverse Fetal Outcomes May Be Linked to Placental Effects

The effects of short-term VPA exposure on placental compound carrier expression were examined in this study.

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

Low Income, Singlehood, and Race Tied to Seizure Control in Active Epilepsy

A majority of participants (67%) had reported seeing a neurologist or epilepsy specialist in the past year, with younger adults comprising a higher percentage of these participants.

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

Briviact Approved for Pediatric Patients With Partial-Onset Seizures

The expanded approval was supported by extrapolated efficacy data from placebo-controlled studies in adults with partial-onset seizures.

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

Comparative Risk for Major Congenital Malformations With High-Dose Antiepileptic Drugs

The prevalence of major congenital malformations in offspring who are prenatally exposed to antiepileptic drugs is highest among those exposed to carbamazepine, phenobarbital doses of >80 mg/day, valproate of ≤650 mg/day, and levetiracetam at 250 to 4000 mg/day.

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

Factors Associated With Treatment Delays in Pediatric Refractory Status Epilepticus

The investigators concluded that these findings should help to identify targets for intervention to reduce the overall time to treatment in this population.

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

Lyrica Approved as Adjunctive Tx for Partial Onset Seizures in Children

The approval was based on a 12-week, double-blind, placebo-controlled study (N=295) in pediatric patients 4-17 years of age.

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

FDA Approves Deep Brain Stimulation Therapy for Refractory Epilepsy

The approval is specifically for bilateral anterior thalamic nucleus stimulation and is based on results from the SANTE study (Stimulation of the Anterior Nucleus of the Thalamus in Epilepsy).

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Too Few Adults Taking Epilepsy Medications Have Seizure Control

Although most adults with epilepsy report taking epilepsy medication, less than half of those report having their seizures controlled.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Rate of Carbamazepine-Induced Cutaneous Adverse Reactions Reduced With Genetic Screening

Researchers evaluated the use of genetic screening to identify individuals who are at risk for carbamazepine-induced cutaneous adverse drug reactions.

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Investigators conducted a population-based study to assess risk and cause of unnatural mortality in individuals with epilepsy.

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

FDA: Lamotrigine Linked to Potentially Life-Threatening Adverse Reaction

Clinicians should conduct a medical evaluation as soon as suspicious symptoms are reported and discontinue lamotrigine if HLH is suspected.

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Researchers conducted post-hoc analysis of data derived from 2 randomized, placebo-controlled trials to determine the safety and tolerability of eslicarbazepine in pediatric patients with partial-onset seizures not responsive to treatment with ≤2 antiepileptic drugs.

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