Epilepsy and Seizures

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Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

Epilepsy's Mobility Problem: Advocating for Changes in Transportation Laws, Public Resources

In individuals who can adequately access healthcare appointments, medications, and other treatments, the combination of driving restrictions and sparse or nonexistent public transportation options interferes with daily living and their overall quality of life.

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Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

Evidence for Clobazam Monotherapy Use in Focal, Generalized Seizures Reviewed

The safety and efficacy of clobazam monotherapy in patients with new-onset focal or generalized seizures was investigated in a new Cochrane systematic review.

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

Weight-Adjusted Lacosamide Effective for Benzodiazepine-Resistant Status Epilepticus

The efficacy was reported to be significantly higher in patients who had taken benzodiazepines.

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Cardiac Pathology in SUDEP Compared With Sudden Arrhythmic or Traumatic Deaths

Causes of death in patients with epilepsy were assessed to determine the presence of cardiac pathology.

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

Vigadrone Available for Refractory Complex Partial Seizures, Infantile Spasms

The FDA has approved an abbreviated New Drug Application for Vigadrone, the generic alternative to Sabril powder for oral solution.

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

Significant Changes in Serotonin Levels Observed Following Epileptic Seizures

Investigators sought to examine whether seizures are capable of causing changes in serotonin levels in the peripheral circulation.

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-Generation Sequencing May Improve Pediatric Epilepsy Tx

Next-generation sequencing can improve treatment efficacy and reduce hospitalization in children with drug-resistant epilepsy.

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

First Marijuana-Based Drug Approved to Treat LGS, Dravet Syndrome

This marks the first approved drug that contains an active ingredient derived from marijuana as well as the first treatment approved for patients with Dravet syndrome.

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Determining Risk Factors for Epilepsy After Symptomatic Neonatal Seizures

Since MRI and EEG risk factors were retrospectively reviewed, the study was unable to analyze the temporal seizure burden or the volume of MRI injury, both of which may have provided greater insights into outcomes.

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

Therapeutic Everolimus Monitoring Range Thresholds Established for Tuberous Sclerosis Complex

The primary efficacy outcome was achieved in a higher percentage of patients in the exposure range of 9 to 15 ng/mL compared with patients in the 3 to 7 ng/mL and >7 to 9 ng/mL ranges.

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