Studies that have evaluated the use of VNS in children, including those as young as 6 months old, and have generally concluded that it is well tolerated and improves quality of life.
This widespread variation in strategies may contribute to undesirable outcomes that are characterized by poor seizure control and added deficits.
Although 2 patients experienced an increase in seizure frequency, the remaining patients did not experience a change in frequency.
Countable seizure types were recorded in parents' and caregivers' clinical diaries during a 4-week baseline period.
The investigators sought to detect whether neuroimaging during an emergency department visit was associated with acute changes in the management of patients.
The risk for late-onset epilepsy was lower in patients with higher physical activity levels and moderate alcohol intake.
Recurrence of seizures was reported in 28.2% of patients who attempted withdrawal.
Clobazam is currently available as oral tablets and suspension under the trade name Onfi (Lundbeck).
Approximately 78% of treated patients experienced at least 1 treatment-related adverse event.
The findings offer some reassurance for clinicians and for pregnant women who are successfully treated with enzyme-inducing ACDs.
Diacomit was evaluated in 2 multicenter, placebo-controlled, double-blind, randomized studies.
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