Epilepsy

Developing and Implementing the New SUDEP Guidelines: An interview with Cynthia Harden, MD

Developing and Implementing the New SUDEP Guidelines: An interview with Cynthia Harden, MD

Dr Cynthia Harden, lead author of the new SUDEP guidelines, discusses the development process and what she hopes clinicians will take away from the guidance.

New Guideline Tackles Sudden Unexpected Death in Epilepsy

New Guideline Tackles Sudden Unexpected Death in Epilepsy

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A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.

Sepsis Associated With Long-term Seizure Risk

Sepsis Associated With Long-term Seizure Risk

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Sepsis is associated with pathways that lead to permanent neurological sequelae.

Maternal BMI May Affect Epilepsy Risk in Offspring

Maternal BMI May Affect Epilepsy Risk in Offspring

Women with higher body mass index were associated with children with a greater epilepsy incidence.

Epilepsy Risk May Increase After Incident Depression

Epilepsy Risk May Increase After Incident Depression

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Underlying pathophysiological mechanisms may connect depression and epilepsy.

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

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Lamotrigine and carbamazepine may represent safer treatment alternatives for girls and women who are or who might become pregnant.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

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In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

International League Against Epilepsy Updates Epilepsy Classification System

International League Against Epilepsy Updates Epilepsy Classification System

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The International League Against Epilepsy has revised its epilepsy classification system in an effort to inform epilepsy research and aid drug development.

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

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Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

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In people with Dravet syndrome, language impairments increase with age, suggesting that early intervention with targeted oral motor therapies may be helpful.

Epilepsy, Seizures Common Among Nursing Home Population

Epilepsy, Seizures Common Among Nursing Home Population

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Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

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There is as much as a 32% risk for vigabatrin-associated brain abnormalities in patients with infantile spasms.

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

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Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

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Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.

Cortical Excitability Tied to Duration and Degree of Seizure Control

Cortical Excitability Tied to Duration and Degree of Seizure Control

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This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

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A subset of epilepsy cases of unknown etiology may be secondary to the production of autoantibodies.

Epilepsy Treatment Often Delayed in Older Adults

Epilepsy Treatment Often Delayed in Older Adults

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Despite recommendations, many patients in the cohort were prescribed older antiepileptic drugs.

Addressing Comorbid Depression in Epilepsy: Challenges in Diagnosis and Treatment

Addressing Comorbid Depression in Epilepsy: Challenges in Diagnosis and Treatment

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There are several drug-based and non-pharmacological treatments available that can help reduce symptoms of depression in patients with epilepsy.

Epilepsy Education Group Helps Patients Cope With Isolation, Anger

Epilepsy Education Group Helps Patients Cope With Isolation, Anger

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Patients who participated in a group course with other people with epilepsy felt less isolated and more confident.

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

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A diagnosis of maternal epilepsy alone was not associated with an increase in congenital malformations in offspring.

Quality Improvement Measures Improve Health Care Utilization in Epilepsy

Quality Improvement Measures Improve Health Care Utilization in Epilepsy

Quality improvement measures help to reduce emergency department visits, inpatient hospitalizations, and health care claims.

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

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Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.

Guidelines for Using fMRI for Presurgical Evaluation of Epilepsy

Guidelines for Using fMRI for Presurgical Evaluation of Epilepsy

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Functional MRI may provide a less-invasive option for evaluating memory function in patients undergoing epilepsy surgery.

Should EEG Periodic Discharges be Managed Similarly to Seizures?

Should EEG Periodic Discharges be Managed Similarly to Seizures?

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Brain oxygenation may be compromised during periodic discharges, ultimately warranting treatment.

Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

Seizure Reduction Likely With Surgery in Nonlesional Neocortical Epilepsy

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Nearly 60% of patients had achieved seizure freedom at last follow-up, 10 to 21 years after surgery.

EEG Patterns in Critically Ill Point to Greater Risk of Seizures

EEG Patterns in Critically Ill Point to Greater Risk of Seizures

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Careful monitoring of EEG patterns is a useful way to stratify seizure risk in critically ill patients.

First-Line Treatment With Carbamazepine in Neonatal Epilepsy

First-Line Treatment With Carbamazepine in Neonatal Epilepsy

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The results confirm the effectiveness and safety of low-dose CBZ as a first-line agent for the treatment of neonatal seizures.

Vigabatrin Plus Hormonal Therapy Superior in Infantile Spasms

Vigabatrin Plus Hormonal Therapy Superior in Infantile Spasms

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Greater spasm cessation was achieved in the combination group vs those who received hormonal therapy alone.

VIDEO: Identifying Risk Factors for Post-Stroke Epilepsy

VIDEO: Identifying Risk Factors for Post-Stroke Epilepsy

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Beate Diehl, MD, PhD, FRCP, discusses her research on post-stroke epilepsy.

VIDEO: Gap in Provider Knowledge Delays Diagnosis, Treatment of Infantile Spasms

VIDEO: Gap in Provider Knowledge Delays Diagnosis, Treatment of Infantile Spasms

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Shaun Hussain, MD, MS, discusses a gap in health care provider knowledge that may contribute to the delay in the diagnosis and treatment of infantile spasms.

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