Epilepsy

Genetic Testing Justified in Early Childhood Epilepsy

Genetic Testing Justified in Early Childhood Epilepsy

In children with epilepsy, genetic investigation that emphasizes sequencing tests should be part of the initial evaluation.

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

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Previous research has found a higher prevalence of depression before and after an epilepsy diagnosis.

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

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The FDA has expanded the age range for the VNS Therapy system.

Partial-Onset Seizure Treatment Discontinued

Partial-Onset Seizure Treatment Discontinued

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Potiga tablets have been discontinued due to the limited use of the medicine.

Case Study: Headache, Confusion, and Seizures in Patient With SLE

Case Study: Headache, Confusion, and Seizures in Patient With SLE

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Woman with SLE complains of headache, confusion, and mild somnolence to the emergency department.

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

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The FDA-sponsored study sought to evaluate the bioequivalence of 2 generic forms of the popular epilepsy treatment lamotrigine.

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Changes in serum concentrations of other anti-epileptic drugs were not found to be significant.

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Those with uncomplicated epilepsy who were seizure-free for five years had social outcomes comparable to their siblings.

Zika Virus May Trigger Epilepsy in Infants

Zika Virus May Trigger Epilepsy in Infants

The finding isn't overly surprising since the types of brain abnormalities seen in Zika-affected newborns have been linked to seizures and epilepsy in the past.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Anup Patel, MD, of Nationwide Children's Hospital and The Ohio State University School of Medicine, discusses findings from a dose-ranging study of cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome. Scroll to below the video for a full text transcript of Dr Patel's interview.

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

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Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Cynthia Harden, MD, lead author of the new SUDEP guidelines, discusses the development process and what she hopes clinicians will take away from the guidance. Scroll to below the video for a full text transcript of Dr Harden's interview.

New Guideline Tackles Sudden Unexpected Death in Epilepsy

New Guideline Tackles Sudden Unexpected Death in Epilepsy

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A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.

Sepsis Associated With Long-term Seizure Risk

Sepsis Associated With Long-term Seizure Risk

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Sepsis is associated with pathways that lead to permanent neurological sequelae.

Maternal BMI May Affect Epilepsy Risk in Offspring

Maternal BMI May Affect Epilepsy Risk in Offspring

Women with higher body mass index were associated with children with a greater epilepsy incidence.

Epilepsy Risk May Increase After Incident Depression

Epilepsy Risk May Increase After Incident Depression

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Underlying pathophysiological mechanisms may connect depression and epilepsy.

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

Valproate for Epilepsy Poses Greater Risk for Major Congenital Malformations

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Lamotrigine and carbamazepine may represent safer treatment alternatives for girls and women who are or who might become pregnant.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

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In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

International League Against Epilepsy Updates Epilepsy Classification System

International League Against Epilepsy Updates Epilepsy Classification System

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The International League Against Epilepsy has revised its epilepsy classification system in an effort to inform epilepsy research and aid drug development.

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

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Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

Distinct Phenotype in Dravet Syndrome Helps Outline Treatment

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In people with Dravet syndrome, language impairments increase with age, suggesting that early intervention with targeted oral motor therapies may be helpful.

Epilepsy, Seizures Common Among Nursing Home Population

Epilepsy, Seizures Common Among Nursing Home Population

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Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

Vigabatrin Dose Affects Risk for Brain Abnormalities in Infantile Spasms

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There is as much as a 32% risk for vigabatrin-associated brain abnormalities in patients with infantile spasms.

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

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Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

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Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.

Cortical Excitability Tied to Duration and Degree of Seizure Control

Cortical Excitability Tied to Duration and Degree of Seizure Control

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This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

Autoimmune Etiology Suggested for Subset of Epilepsy Diagnoses

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A subset of epilepsy cases of unknown etiology may be secondary to the production of autoantibodies.

Epilepsy Treatment Often Delayed in Older Adults

Epilepsy Treatment Often Delayed in Older Adults

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Despite recommendations, many patients in the cohort were prescribed older antiepileptic drugs.

Addressing Comorbid Depression in Epilepsy: Challenges in Diagnosis and Treatment

Addressing Comorbid Depression in Epilepsy: Challenges in Diagnosis and Treatment

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There are several drug-based and non-pharmacological treatments available that can help reduce symptoms of depression in patients with epilepsy.

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