Epilepsy

Dose "Ceiling" May Exist for Epilepsy Treated With Lamotrigine

Dose "Ceiling" May Exist for Epilepsy Treated With Lamotrigine

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A "ceiling" may exist for lamotrigine therapy above which remission from seizures may be unlikely.

FDA Approves Vagus Nerve Stimulator for Refractory Epilepsy

FDA Approves Vagus Nerve Stimulator for Refractory Epilepsy

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The system includes a detect-and-respond mode, which is designed to prevent seizures before they start and deliver therapy to stop them if they do.

Epilepsy in the US: A Growing Public Health Concern

Epilepsy in the US: A Growing Public Health Concern

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The CDC has updated the US national estimate of epilepsy prevalence and estimates 3.4 million people are affected by epilepsy.

Seizures More Likely in Patients With Sepsis Than General Population

Seizures More Likely in Patients With Sepsis Than General Population

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Patients with sepsis included in this analysis may have presented with other CNS pathologies that could have contributed to seizure risk.

Incidence of Seizures and Epilepsy High in Ischemic Stroke

Incidence of Seizures and Epilepsy High in Ischemic Stroke

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Newer antiepileptic drugs were associated with fewer adverse effects in patients with ischemic stroke.

Antiepileptic Drugs Increase Risk of Birth Complications, Poor Fetal Health

Antiepileptic Drugs Increase Risk of Birth Complications, Poor Fetal Health

Pregnant women on antiepileptic drugs are at a higher risk of giving birth to a premature and SGA infant.

FDA Approves Expanded Seizure Indication for Aptiom

FDA Approves Expanded Seizure Indication for Aptiom

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The FDA has approved an expanded indication for Aptiom to treat pediatric partial-onset seizures.

FDA Approves Briviact for Partial-Onset Seizure Monotherapy

FDA Approves Briviact for Partial-Onset Seizure Monotherapy

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Briviact was initially approved as adjunct treatment for partial-onset seizures.

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

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Rectal diazepam is currently the only FDA-approved treatment for pediatric status epilepticus.

Epilepsy Incidence Rates on the Rise in US Adults

Epilepsy Incidence Rates on the Rise in US Adults

Over 1% of the US population reported active or current epilepsy in 2015.

Cannabidiol May Impact Antiepileptic Drug Levels in Refractory Epilepsy

Cannabidiol May Impact Antiepileptic Drug Levels in Refractory Epilepsy

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While several studies have demonstrated efficacy in refractory epilepsy, it is still not clear how cannabidiol may have an impact on current epilepsy treatments.

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone may help wean patients with super-refractory status epilepticus off of third-line agents.

Review Supports Current NICE Guidelines for Tx of Partial Onset Seizures

Review Supports Current NICE Guidelines for Tx of Partial Onset Seizures

For people with seizures, levetiracetam is more effective than carbamazepine and lamotrigine.

Genetic Testing Justified in Early Childhood Epilepsy

Genetic Testing Justified in Early Childhood Epilepsy

In children with epilepsy, genetic investigation that emphasizes sequencing tests should be part of the initial evaluation.

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

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Previous research has found a higher prevalence of depression before and after an epilepsy diagnosis.

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

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The FDA has expanded the age range for the VNS Therapy system.

Partial-Onset Seizure Treatment Discontinued

Partial-Onset Seizure Treatment Discontinued

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Potiga tablets have been discontinued due to the limited use of the medicine.

Case Study: Headache, Confusion, and Seizures in Patient With SLE

Case Study: Headache, Confusion, and Seizures in Patient With SLE

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Woman with SLE complains of headache, confusion, and mild somnolence to the emergency department.

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

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The FDA-sponsored study sought to evaluate the bioequivalence of 2 generic forms of the popular epilepsy treatment lamotrigine.

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Ketogenic Diet: Evaluating Effects on Epilepsy Treatments

Changes in serum concentrations of other anti-epileptic drugs were not found to be significant.

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Quality of Life Outcomes in Uncomplicated Childhood Epilepsy

Those with uncomplicated epilepsy who were seizure-free for five years had social outcomes comparable to their siblings.

Zika Virus May Trigger Epilepsy in Infants

Zika Virus May Trigger Epilepsy in Infants

The finding isn't overly surprising since the types of brain abnormalities seen in Zika-affected newborns have been linked to seizures and epilepsy in the past.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Anup Patel, MD, of Nationwide Children's Hospital and The Ohio State University School of Medicine, discusses findings from a dose-ranging study of cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome. Scroll to below the video for a full text transcript of Dr Patel's interview.

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

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Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Cynthia Harden, MD, lead author of the new SUDEP guidelines, discusses the development process and what she hopes clinicians will take away from the guidance. Scroll to below the video for a full text transcript of Dr Harden's interview.

New Guideline Tackles Sudden Unexpected Death in Epilepsy

New Guideline Tackles Sudden Unexpected Death in Epilepsy

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A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.

Sepsis Associated With Long-term Seizure Risk

Sepsis Associated With Long-term Seizure Risk

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Sepsis is associated with pathways that lead to permanent neurological sequelae.

Maternal BMI May Affect Epilepsy Risk in Offspring

Maternal BMI May Affect Epilepsy Risk in Offspring

Women with higher body mass index were associated with children with a greater epilepsy incidence.

Epilepsy Risk May Increase After Incident Depression

Epilepsy Risk May Increase After Incident Depression

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Underlying pathophysiological mechanisms may connect depression and epilepsy.

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