General Neurology

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

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These Medication Guides should be provided the first time an outpatient receives a GBCA injection at an MRI center; hospital patients are not required to receive a Medication Guide.

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

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The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

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Evidence on whether the implementation of prescription drug monitory programs increases or decreases opioid-related overdoses was found to be "largely insufficient".

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

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Experts discuss the symptoms and prevalence of neurological manifestations in Sjogren syndrome.

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

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While immunocompromised patients are the most susceptible to CNS fungal infections, they can also occur in immunocompetent patients undergoing invasive procedures such as neurosurgery and in patients exposed to contaminated devices or drugs.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

FDA-Approved App Allows Clinicians to Objectively Measure Balance

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The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative fateful life events in midlife are associated with advanced predicted brain aging.

Atraumatic Needles Reduce Headache Incidence Following Lumbar Puncture

Atraumatic Needles Reduce Headache Incidence Following Lumbar Puncture

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Investigators assessed the impact of atraumatic vs conventional needles on patient outcomes after lumbar puncture.

Later Natural Menopause Can Benefit Future Verbal Memory

Later Natural Menopause Can Benefit Future Verbal Memory

Women who have a later natural menopause maintain a small benefit in verbal memory compared with women with earlier menopause.

Human neural stem cell grafts in rhesus monkeys improve motor function after spinal cord injury [PreClinical]

Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells.

A Zika vaccine could virtually eliminate prenatal infections

Zika vaccine provides 90% coverage and is targeted for immunization of women aged 9 to 49 years.

Flucytosine plus fluconazole is noninferior to amphotericin B in treating cryptococcal meningitis

Treatment of cryptococcal meningitis with two weeks of flucytosine and fluconazole was noninferior to two weeks of amphotericin B.

Early intrauterine Zika infection linked to birth defects among infants in the US French Territories

A prospective cohort including pregnant women in the US French Territories with PCR-confirmed Zika virus (ZIKV) infection found a 7% overall risk of neurologic and ocular defects among subsequent offspring.

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

Untrimmed Toenails: A Marker of Functional Status in Older Patients?

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For older patients, toenail length can provide important insight into a patient's functional status.

Preserved Neurogenesis in Hippocampus of Healthy Seniors

Preserved Neurogenesis in Hippocampus of Healthy Seniors

Noting that aging humans are thought to exhibit waning neurogenesis and exercise-induced angiogenesis, researchers examined whole-autopsy hippocampi from healthy humans.

Relapse in Major Depression Linked to Brain Cortical Changes

Relapse in Major Depression Linked to Brain Cortical Changes

For patients with major depressive disorde, relapse is associated with brain cortical changes over two years.

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

Early Infection With Zika Virus Associated With More Birth Defects in Pregnancy

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Among pregnant women with Zika virus infection, birth defects were reported more often in fetuses and infants whose mothers had been infected with the virus early in their pregnancies.

Neural Markers of Depression Resilience ID'd in Female Teens

Neural Markers of Depression Resilience ID'd in Female Teens

Adolescent females at high familial risk of depression who do not go on to develop depression have compensatory functional connectivity patterns in emotion regulatory networks.

Amygdala Neurons Reduced in Adults With Autism

Amygdala Neurons Reduced in Adults With Autism

Researchers reported the results of a stereological analysis of the number of neurons in the amygdala nuclei to compare neurotypical development to autism spectrum disorder development.

Predicting Neurological Outcome in Unconscious Cardiac Arrest With White Matter Fractional Anisotropy

Predicting Neurological Outcome in Unconscious Cardiac Arrest With White Matter Fractional Anisotropy

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The normalized WWM-FA value demonstrated the greatest prognostic accuracy compared with MRI sequences or standard criteria for unfavorable neurological outcome.

Navigating the Ethics of Agents for Pharmacological Cognitive Enhancement

Navigating the Ethics of Agents for Pharmacological Cognitive Enhancement

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The focus on enhanced cognitive function could sideline equally important aspects of life such as health and relationships.

Hormone Therapy May Impact Brain Structure, Cognition

Hormone Therapy May Impact Brain Structure, Cognition

3 years after menopausal HT, change in brain volumes were not significantly different from placebo.

Anesthesia, Surgery Affect Postoperative Neurological Outcomes

Anesthesia, Surgery Affect Postoperative Neurological Outcomes

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Investigators examined plasma tau concentrations in blood samples obtained from patients who received general anesthesia for surgery.

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

Risk of Altered Mental Status in Gabapentin-Treated Patients Explored

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The study included 110,184 adults (mean age: 76 years) newly started on gabapentin therapy in Ontario, Canada.

Altered Neural Responses in Memory Processing in T1DM

Altered Neural Responses in Memory Processing in T1DM

Significantly stronger neural responses in superior parietal cortices during memory encoding in T1DM.

Zika Virus-Associated Neurogenic Bladder Requires Prompt Management

Zika Virus-Associated Neurogenic Bladder Requires Prompt Management

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Prompt identification may help reduce the risk for subsequent renal failure and minimize overall disease burden.

FDA Fast Tracks Treatment for Fragile X Syndrome

FDA Fast Tracks Treatment for Fragile X Syndrome

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OV101 has previously been granted Orphan Drug status for Fragile X and Fast Track status for Angelman syndrome.

No Benefit for MRI After Normal Cervical CT in Blunt Trauma

No Benefit for MRI After Normal Cervical CT in Blunt Trauma

MRI had lower health benefit and higher cost compared with no follow-up after normal CT findings.

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