General Neurology

FDA Grants Orphan Drug Status to Angelman Syndrome Treatment

FDA Grants Orphan Drug Status to Angelman Syndrome Treatment

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Delay or lack of speech, seizures, and walking/balance disorders are some of the symptoms associated with AS.

Anti-CD47 Antibody Granted Orphan Drug Designation for Multiple Myeloma

Anti-CD47 Antibody Granted Orphan Drug Designation for Multiple Myeloma

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The FDA has granted Orphan Drug designation to Surface Oncology's lead investigational candidate SRF231, a potential treatment for patients with multiple myeloma.

Fake FDA Warning Letters Being Sent to Consumers

Fake FDA Warning Letters Being Sent to Consumers

Criminals are sending fake US Food and Drug Administration warning letters to people who tried to buy medicines online or over the phone.

FDA Outlines Plan for Increasing Nonprescription Drug Availability

FDA Outlines Plan for Increasing Nonprescription Drug Availability

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The FDA has released new guidance for drug developers that could potentially lead to the approval of a wider range of nonprescription drug products, allowing patients to "self-treat" some acute conditions and possibly chronic ones as well.

Cerebral Infarction in Meningitis Linked to Genetic Variant

Cerebral Infarction in Meningitis Linked to Genetic Variant

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The prospective study was performed in patients ≥16 years of age with community-acquired bacterial meningitis.

FDA Announces New Drug Shortages Task Force

FDA Announces New Drug Shortages Task Force

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Gottlieb said "The charge to this new task force is to look for holistic solutions to addressing the underlying causes for these [drug] shortages."

Sleep Apnea Linked to Changes in the Brain in Older Adults

Sleep Apnea Linked to Changes in the Brain in Older Adults

Obstructive sleep apnea is associated with changes to the structure of the brain that are seen in the early stages of dementia.

 FDA: Individual Blood Donations No Longer Need to Be Tested for Zika Virus

FDA: Individual Blood Donations No Longer Need to Be Tested for Zika Virus

Individual blood donations will no longer need to be tested for the Zika virus.

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

Co-Prescription of Opioids and Antidepressants Prevalent in Migraine

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Researchers sought to assess the prevalence of concomitant prescribing of opioid analgesics with a triptan or a serotogeneric antidepressant in individuals with migraine.

Anticonvulsants Seem to Be Ineffective for Low Back Pain

Anticonvulsants Seem to Be Ineffective for Low Back Pain

Anticonvulsant drugs are ineffective for chronic low back pain and can cause harm, despite a recent increase in prescribing.

Drug Used for Reversal of Neuromuscular Block Recalled Due to Mislabeling

Drug Used for Reversal of Neuromuscular Block Recalled Due to Mislabeling

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Neostigmine Methylsulfate Injection, a cholinesterase inhibitor, is indicated to reverse the effects of non-depolarizing neuromuscular blockers after surgery.

Menkes Disease Treatment Granted Fast Track Status by FDA

Menkes Disease Treatment Granted Fast Track Status by FDA

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CUTX-101, a subcutaneous injectable formulation of copper histidinate, is designed to supplement blood and brain copper levels in patients with Menkes disease.

Some California Mosquitoes Can Carry Zika Virus

Some California Mosquitoes Can Carry Zika Virus

Aedes aegypti mosquitoes can spread the Zika virus.

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis Use Linked to Psychosis Symptoms in Adolescents

Cannabis use is associated with psychosis symptoms during adolescence.

One-Third of U.S. Children, Teens Use Dietary Supplements

One-Third of U.S. Children, Teens Use Dietary Supplements

Approximately one-third of US children and adolescents use dietary supplements.

IV Fluid Specs Do Not Influence Neuro Outcomes in Kids With DKA

IV Fluid Specs Do Not Influence Neuro Outcomes in Kids With DKA

Neurologic outcomes in children with diabetic ketoacidosis are similar regardless of the rate of administration or the NaCl content of intravenous fluids.

White Matter Hyperintensities in RCVS Vary Over Time

White Matter Hyperintensities in RCVS Vary Over Time

White matter hyperintense lesions in patients with reversible cerebral vasoconstriction syndrome change over time in a manner that parallels disease severity.

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

Taking Advantage of a Drug-Drug Interaction: A Case of Valproic Acid Toxicity

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Short-term administration of carbapenem antibiotics may be beneficial in the treatment of VPA overdose in patients with no history of seizure disorder.

Should Genealogy Data Be Used for Criminal Justice Purposes?

Should Genealogy Data Be Used for Criminal Justice Purposes?

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Informed consent, privacy, and justice concerns are 3 issues that should be addressed before the use of online genealogy data in criminal cases becomes widely adopted.

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

Accumulation of Brain Pathologies Linked to Reduced Activity in Older Adults

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Brain autopsies of participants of the Rush Memory Aging project (n=428) were studied to identify the association between brain pathologies and total daily physical activity and mortality.

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

Lenti-D Gets Breakthrough Tx Designation for Cerebral Adrenoleukodystrophy

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The FDA has granted Breakthrough Therapy designation to Lenti-D for the treatment of patients with cerebral adrenoleukodystrophy.

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

FDA: New Med Guide for Patients Receiving Gadolinium-Based Contrast Agents

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These Medication Guides should be provided the first time an outpatient receives a GBCA injection at an MRI center; hospital patients are not required to receive a Medication Guide.

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

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The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

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Evidence on whether the implementation of prescription drug monitory programs increases or decreases opioid-related overdoses was found to be "largely insufficient".

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

Expert Insight: A Closer Look at Neurological Manifestations of Sjogren Syndrome

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Experts discuss the symptoms and prevalence of neurological manifestations in Sjogren syndrome.

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

Fungal Infections of the CNS: Diagnostic and Treatment Approaches

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While immunocompromised patients are the most susceptible to CNS fungal infections, they can also occur in immunocompetent patients undergoing invasive procedures such as neurosurgery and in patients exposed to contaminated devices or drugs.

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

Ventriculomegaly, Polymicrogyria Predict Epilepsy Risk Among Pediatric Patients With Cytomegalovirus Infections

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Investigators retrospectively reviewed the patients' medical records and MRI images and assessed the associations between the MRI findings and neurologic outcomes, specifically neurodevelopmental achievement, epilepsy, and sensorineural hearing loss.

FDA-Approved App Allows Clinicians to Objectively Measure Balance

FDA-Approved App Allows Clinicians to Objectively Measure Balance

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The application assesses 3 key balance metrics: (1) double stance, (2) right tandem stance, and (3) left tandem stance.

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative fateful life events in midlife are associated with advanced predicted brain aging.

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