Huntington’s Disease

Defining Unique Needs for Palliative and Hospice Care in Huntington Disease

Defining Unique Needs for Palliative and Hospice Care in Huntington Disease

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Research has shown significant gaps in knowledge on palliative services among neurology residents, resulting in low referral rates.

Neurofilament Light Protein Shows Strong Potential as Biomarker for Huntington's Disease

Neurofilament Light Protein Shows Strong Potential as Biomarker for Huntington's Disease

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Investigators examined blood plasma samples taken annually from a cohort of 201 huntingtin gene (HTT) carriers.

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

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Early onset of motor symptoms related to substance abuse appeared to significantly affect women compared with men.

Austedo Approved for Huntington's Chorea

Austedo Approved for Huntington's Chorea

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Deutetrabenazine is only the second drug approved for patients with Huntington's disease.

Multiple Genetic Variations of Huntington's Disease Identified

Multiple Genetic Variations of Huntington's Disease Identified

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The study supports the need for clinicians to initiate genetic counseling in patients who show clinical signs of HD.

Novel Therapy May Improve Chorea Symptoms in Huntington's Disease

Novel Therapy May Improve Chorea Symptoms in Huntington's Disease

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The drug has a similar mechanism of action as tetrabenazine, but a different pharmacokinetic profile.

Huntington's Disease May Be More Prevalent Than We Think

Huntington's Disease May Be More Prevalent Than We Think

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The HD-associated CAG repeat with 36 or more repeats was found in 18 individuals.

Targeted Drug May Slow Huntington's Disease Progression

Targeted Drug May Slow Huntington's Disease Progression

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A new drug that inhibits the production of HTT mRNA may help slow progression of Huntington's disease.

Novel Huntington's Treatment Wins Orphan Drug Status

Novel Huntington's Treatment Wins Orphan Drug Status

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The FDA has granted Orphan Drug designation to IONIS-HTT (Ionis) for the treatment of Huntington's disease.

Boosting Proteasome Function May Prevent Spread of Tau Protein

Boosting Proteasome Function May Prevent Spread of Tau Protein

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Addressing proteasome dysfunction may help prevent accumulation of the toxic protein.

FDA Accepts Drug Application for Huntington's Disease Agent

FDA Accepts Drug Application for Huntington's Disease Agent

The FDA has accepted an application for SD-809 (deutetrabenazine) for the treatment of chorea associated with Huntington's disease.

Triheptanoin Oil May Improve Brain Metabolism in Huntington's Disease

Triheptanoin Oil May Improve Brain Metabolism in Huntington's Disease

With no control group, researchers also considered that the positive response was a placebo effect.

Criminal Behavior More Likely in Frontotemporal Dementia

Criminal Behavior More Likely in Frontotemporal Dementia

Patients with bvFTD are more likely to exhibit criminal behavior like theft and public urination.

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