Ischemic Stroke

ENCHANTED Update: No Role for Low-Dose Alteplase After All?

ENCHANTED Update: No Role for Low-Dose Alteplase After All?

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Results from a secondary analysis of the ENCHANTED trial add to a pile of weak data that likely will not affect clinical practice.

Stroke Severity, Collateral Blood Flow Indicate ASPECTS Decay

Stroke Severity, Collateral Blood Flow Indicate ASPECTS Decay

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Significant infarct progression can make patients ineligible for mechanical thrombectomy.

After Stroke, High-Intensity Statin Therapy Linked to Fewer Adverse Events

After Stroke, High-Intensity Statin Therapy Linked to Fewer Adverse Events

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The findings support the continuation of high-intensity statin therapy after acute ischemic stroke.

High-Risk Stroke Patients With Insulin Resistance Benefit More From Pioglitazone

High-Risk Stroke Patients With Insulin Resistance Benefit More From Pioglitazone

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Insulin-resistant patients with ischemic stroke or transient ischemic attack and a high risk of myocardial infarction or recurrent stroke are more likely to derive benefit from pioglitazone than those a lower risk.

Thromboembolic Events Most Frequent Mechanism in Postoperative Ischemic Stroke

Thromboembolic Events Most Frequent Mechanism in Postoperative Ischemic Stroke

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A better understanding of characteristics of cerebral lesions may help expedite treatment and improve functional outcomes.

Rivaroxaban, Warfarin Show Similar Efficacy in AFib-Related Ischemic Stroke

Rivaroxaban, Warfarin Show Similar Efficacy in AFib-Related Ischemic Stroke

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The investigators noted that rivaroxaban was associated with significantly reduced length of hospital stay compared with warfarin.

Intravenous Thrombolysis Plus Mechanical Thrombectomy Improves Stroke Outcomes

Intravenous Thrombolysis Plus Mechanical Thrombectomy Improves Stroke Outcomes

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The findings align with current guidelines to administer IV tPA regardless of whether or not a patient with ischemic stroke is set to undergo mechanical thrombectomy.

Predicting Cerebral Edema Severity After Stroke

Predicting Cerebral Edema Severity After Stroke

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There is some evidence that suggests intravenous thrombolysis for stroke may impair the blood-brain barrier and cause cerebral edema.

No Benefit of Contact Aspiration Over Stent Retriever in Ischemic Stroke

No Benefit of Contact Aspiration Over Stent Retriever in Ischemic Stroke

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The findings may be less applicable to low-volume stroke centers who have less experience in this treatment.

Adult Ischemic Stroke Associated With Higher Childhood BMI

Adult Ischemic Stroke Associated With Higher Childhood BMI

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Investigators found a positive association between higher childhood BMI scores and early adult ischemic stroke.

THRIVE Score Accurately Predicts Ischemic Stroke Treatment Outcomes

THRIVE Score Accurately Predicts Ischemic Stroke Treatment Outcomes

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THRIVE scores not only accurately predicted good and poor outcomes in stroke patients following IVT or ET, but also the degree of ischemia following these treatments.

Expert Analysis: Tenecteplase Yet to Prove Itself vs Alteplase

Expert Analysis: Tenecteplase Yet to Prove Itself vs Alteplase

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Despite disappointing results, tenecteplase's story in stroke treatment might not be over.

Poststroke Deficit Recrudescence: Signs and Symptoms to Look For

Poststroke Deficit Recrudescence: Signs and Symptoms to Look For

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Women and patients of African-American race face an increased risk of experiencing poststroke recrudescence.

Poor Glycemic Control After Ischemic Stroke Linked to Poor Outcomes

Poor Glycemic Control After Ischemic Stroke Linked to Poor Outcomes

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Only 16% of patients had an adequate response to conventional therapy, with patients who didn't considered "non-responders."

Predicting Major Bleeding in Patients With Stroke on Antiplatelets

Predicting Major Bleeding in Patients With Stroke on Antiplatelets

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There are a limited number of prediction models that identify patients at risk of major bleeding after stroke or TIA.

Primary Stroke Center Protocol Significantly Improves Outcomes

Primary Stroke Center Protocol Significantly Improves Outcomes

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Reduced door-to-needle times have been shown to improve outcomes after stroke.

Higher Risk for Symptomatic Intracranial Hemorrhage After Endovascular Treatment for Stroke

Higher Risk for Symptomatic Intracranial Hemorrhage After Endovascular Treatment for Stroke

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Risk for symptomatic intracranial hemorrhage after endovascular treatment for acute ischemic stroke is significantly higher in real-world practice than rates reported by clinical trials.

Mechanical Thrombectomy Safe in Older Stroke Patients

Mechanical Thrombectomy Safe in Older Stroke Patients

No between-group differences were observed for reperfusion success and mortality, among other measures.

After Stroke, Intensive Antiplatelet Therapy Has Benefits, Drawbacks

After Stroke, Intensive Antiplatelet Therapy Has Benefits, Drawbacks

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Intensive antiplatelet therapy appears to reduce risk of recurrence immediately after stroke, but may pose risks further out.

Stroke Awareness: Do Your Patients Know the Signs?

Stroke Awareness: Do Your Patients Know the Signs?

New research from the American Heart and American Stroke Associations found that many Americans don't know the symptoms of stroke.

Ischemic Stroke Risk Elevated in Systemic Lupus Erythematosus

Ischemic Stroke Risk Elevated in Systemic Lupus Erythematosus

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The relative risk of developing ischemic stroke was increased in patients with systemic lupus erythematosus, especially within the first year after diagnosis.

Improving Stroke Diagnosis Accuracy: An Interview With David Newman-Toker, MD, PhD

Improving Stroke Diagnosis Accuracy: An Interview With David Newman-Toker, MD, PhD

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Neurologists need to engage their emergency medicine colleagues to identify protocols and pathways for when to trigger appropriate neurological consultation or initiate acute stroke therapies.

Endovascular Stroke Treatment Shows Sustained Response Up to 2 Years

Endovascular Stroke Treatment Shows Sustained Response Up to 2 Years

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Over 32% of patients were functionally independent at 90 days and 37.1% were functionally independent at 2 years.

In Ischemic Stroke, Pulse Pressure Predicts Long-Term Risk of Recurrence

In Ischemic Stroke, Pulse Pressure Predicts Long-Term Risk of Recurrence

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Pulse pressure was associated with the risk for ischemic stroke in first-ever ischemic stroke patients old than 60 years.

IV tPA Effective for Stroke in Patients With Increased Body Weight

IV tPA Effective for Stroke in Patients With Increased Body Weight

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Previous research had suggested that the benefits of IV tPA are diminished in patients weighing more than 100 kg.

Migraine Linked to Ischemic Stroke Via Cervical Artery Dissection

Migraine Linked to Ischemic Stroke Via Cervical Artery Dissection

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Up to 20% of stroke cases in young adults occur in those with cervical artery dissection, the leading cause of stroke in this population.

Prestroke CHA2DS2-VASc Score Predicts Stroke Severity, Outcomes

Prestroke CHA2DS2-VASc Score Predicts Stroke Severity, Outcomes

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Clinicians should closely monitor patients with atrial fibrillation, especially if they are female and of increasing age.

Intensive Antiplatelet Therapy and Risk of Recurrent Stroke

Intensive Antiplatelet Therapy and Risk of Recurrent Stroke

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Efficacy of triple antiplatelet therapy compared with current guideline-based therapy for the prevention of recurrent stroke was evaluated in the TARDIS trial.

Contact Aspiration vs Stent Retriever in Acute Ischemic Stroke

Contact Aspiration vs Stent Retriever in Acute Ischemic Stroke

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The results provide good evidence for the use of contact aspiration in ischemic stroke.

Time to Alteplase Treatment Affected by Hospital Delays, Medical Conditions

Time to Alteplase Treatment Affected by Hospital Delays, Medical Conditions

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Delays related to the determination of treatment eligibility increased door-to-needle times by more than 30 minutes compared with patients with no delays.

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