Elevated WBC Count
Consider white blood cell (WBC) proliferation in patients with infections and other inflammatory states, such as autoimmune disorders.
An increase in neutrophils commonly occurs during a bacterial infection.
Lymphocytosis can be found in tuberculosis (TB), acute bowel infections, and infectious mononucleosis.
Monocyte count is usually increased along with an elevated lymphocyte count.
Eosinophils can become increased in patients with allergic disorders, asthma, certain parasitic, and dermatologic disorders.
Elevated WBC counts may also be detected in patients with a variety of different types of leukemia and lymphomas.
It is important to promptly recognize an elevated WBC count associated with a diagnosis of leukemia or lymphoma.
Commonly Encountered Situations
Non-neoplastic proliferations of WBCs most commonly involve an increase in neutrophils with bacterial infection.
Elevation in lymphocytes and monocytes in patients with autoimmune disease is also frequently encountered.
Suggested Additional Lab Testing
The most important test is the WBC count and differential.
Peripheral blood smear and bone marrow aspirate, with or without bone marrow biopsy, is informative in the diagnosis of certain WBC proliferative states.
Serum protein electrophoresis with further evaluation is indicated if a plasma cell dyscrasia is found.
An evaluation for infection, either bacterial or parasitic, is useful if there is an increase in eosinophils.
Tests for autoimmune diseases (e.g., systemic lupus erythematous [SLE], rheumatoid arthritis) may explain an elevated lymphocyte and monocyte cell count.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Next Article in LabMed
Neurology Advisor Articles
- Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive Impairment
- Galcanezumab Significantly Reduces Migraine Headaches vs Placebo
- Noninvasive Vagus Nerve Stimulation Effective for Episodic Cluster Headaches
- Guidelines: Opioids for the Treatment of Refractory Restless Legs Syndrome
- Migraine Risk Significantly Reduced With Investigational Drug
- Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6
- Apixaban Not Superior to Warfarin for Reducing Stroke Risk in Atrial Fibrillation
- Electrostimulation Plus Task Training Improves Upper Limb Function After Stroke
- Stroke Neurocognitive Outcomes Improved With Gingko Biloba Extract
- Subcortical Microinfarcts Associated With Decreased Blood Pressure in Elderly