LabMed
Prekallikrein Deficiency – Congenital
-
At a Glance
-
What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful?
-
Are There Any Factors That Might Affect the Lab Results? In particular, does your patient take any medications - OTC drugs or Herbals - that might affect the lab results?
-
What Lab Results Are Absolutely Confirmatory?
-
What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful?
At a Glance
Prekallikrein deficiency is a rare disorder seen in all ethnic groups. It is autosomal recessive in inheritance. It is associated with a mildly prolonged partial thromboplastin time (PTT) that will correct when incubated on the bench with all reagents for 1 hour. Its deficiency is not associated with bleeding.
What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful?
Test results consistent with a diagnosis of prekallikrein deficiency include PTT 35-45 sec and a low value for a plasma prekallikrein assay (coagulant or chromogenic).(
Table 1
Test Results Indicative of the Disorder
APTT | Plasma Prekallikrein Assay |
---|---|
35-45 sec | <10% |
Are There Any Factors That Might Affect the Lab Results? In particular, does your patient take any medications - OTC drugs or Herbals - that might affect the lab results?
Anticoagulants that interfere with clot-based assay, such as unfractionated heparin, enoxaparin, argatroban, bivalirudin, hirudin, and dabigatran, will interfere with laboratory results.
What Lab Results Are Absolutely Confirmatory?
Low prekallikrein assay with no evidence for a defect in other intrinsic coagulation factors and no lupus anticoagulant is absolutely confirmatory.
What Tests Should I Request to Confirm My Clinical Dx? In addition, what follow-up tests might be useful?
Low prekallikrein assay without evidence for an inhibitor to plasma prekallikrein should be requested.
Copyright © 2017, 2013 Decision Support in Medicine, LLC. All rights reserved.
No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. The Licensed Content is the property of and copyrighted by DSM.
Neurology Advisor Articles
- The Consequences of Compensation in Autism
- Fingolimod May Help Prevent Brain Volume Loss in Relapsing-Remitting Multiple Sclerosis
- Demoralization Common in Patients With Parkinson Disease
- Connection Between Essential Tremor, Depression Remains Unclear
- American Academy of Neurology Annual Meeting 2018: What to Expect
- Palliative Care in Movement Disorders: Recommendations for Improvement
- The Symbiosis of Headache and Sleep
- Assessing and Treating Cognitive, Mood Impairments in Patients With Stroke
- Fingolimod May Help Prevent Brain Volume Loss in Relapsing-Remitting Multiple Sclerosis
- Headache in Older Adults: Unique Causes and Treatments
- AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis
- AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy
- AAN: Occupational Exposure to Diesel Exhaust Tied to ALS Risk
- AAN: Adherence to DASH Diet May Reduce Risk of Depression
- AAN: Alpha-Synuclein Levels in Tears May Help ID Parkinson's