Lennox-Gastaut Syndrome

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

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Clobazam is currently FDA-approved for the treatment of seizures associated with Lennox-Gastaut syndrome in children 2 years and older.

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

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The study was a post-hoc analysis of responders who were on or off concomitant clobazam.

Add-on Cannabidiol Generally Safe for Treatment-Resistant Epilepsy, Dravet, Lennox-Gastaut Syndromes

Add-on Cannabidiol Generally Safe for Treatment-Resistant Epilepsy, Dravet, Lennox-Gastaut Syndromes

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Adverse reactions in the CBD group included decreased appetite, diarrhea, fatigue, lethargy, nasopharyngitis, pneumonia, pyrexia, rash, and somnolence.

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Anup Patel, MD, of Nationwide Children's Hospital and The Ohio State University School of Medicine, discusses findings from a dose-ranging study of cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome. Scroll to below the video for a full text transcript of Dr Patel's interview.

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

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Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.

VIDEO: Elizabeth Thiele, MD, PhD Discusses Latest Cannabidiol Research

VIDEO: Elizabeth Thiele, MD, PhD Discusses Latest Cannabidiol Research

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Elizabeth Thiele, MD, PhD discusses results from her research on cannabidiol in Lennox-Gastaut syndrome.

VIDEO — Industry Update: Justin Gover, CEO, GW Pharmaceuticals on Epidiolex Status

VIDEO — Industry Update: Justin Gover, CEO, GW Pharmaceuticals on Epidiolex Status

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Justin Gover, CEO of GW Pharmaceuticals, the parent company of Greenwich Biosciences, discusses the status of the company's cannabidiol product Epidiolex on the heels of positive results from several placebo-controlled trials in epileptic syndromes.

Cannabidiol Helps Reduce Frequency of Drop Seizures in Lennox-Gastaut Syndrome

Cannabidiol Helps Reduce Frequency of Drop Seizures in Lennox-Gastaut Syndrome

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Patients taking cannabidiol experienced a significant reduction in drop seizures compared with placebo.

VIDEO: Cannabidiol and Our Progress Towards a Treatment for Refractory Epilepsy

VIDEO: Cannabidiol and Our Progress Towards a Treatment for Refractory Epilepsy

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Dr Elizabeth Thiele discusses the latest on cannabidiol research for the treatment of refractory epilepsy.

Clobazam Reduces Seizure-Related Injuries in Lennox-Gastaut Syndrome

Clobazam Reduces Seizure-Related Injuries in Lennox-Gastaut Syndrome

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The study translated the primary end point into a clinical benefit for patients.

Cannabidiol Therapy Reduces Seizure Frequency in Dravet Syndrome

Cannabidiol Therapy Reduces Seizure Frequency in Dravet Syndrome

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The drug has already been given Orphan Drug and Fast Track Designation for the treatment of Dravey syndrome.

Cannabidiol Effective for Reducing Seizures in Treatment-Resistant Epilepsy

Cannabidiol Effective for Reducing Seizures in Treatment-Resistant Epilepsy

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A large, multi-center study found cannabidiol effective for the reduction of seizures

Genetic Mutation Identification Expands Epilepsy Phenotypes

Genetic Mutation Identification Expands Epilepsy Phenotypes

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Mutations were identified in 7 genes, including one for the first time.

Benefits and Complications of the Ketogenic Diet for Epilepsy

Benefits and Complications of the Ketogenic Diet for Epilepsy

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Implementing a ketogenic diet in patients with drug-resistant epilepsy could produce significant reductions in seizure frequency.

Some Patients with Lennox-Gastaut Find Success with Surgery

Some Patients with Lennox-Gastaut Find Success with Surgery

New data supports the use of resective surgery in patients with Lennox-Gastaut syndrome.

Efficacy of Marijuana for Pediatric Epilepsy Still in Question

Efficacy of Marijuana for Pediatric Epilepsy Still in Question

Patients and parents perceive cannabidiol as effective in treating seizures, but the evidence is largely anecdotal.

Clobazam Reduced Drop Attacks in Lennox-Gestaut Syndrome

Clobazam Reduced Drop Attacks in Lennox-Gestaut Syndrome

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Clobazam was safe and effective in reducing atonic seizures among patients with Lennox-Gestaut syndrome who participated in the CONTAIN trial.

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