Mild Cognitive Impairment

Promising Improvements in Mild Cognitive Impairment With Investigational NA-831

Promising Improvements in Mild Cognitive Impairment With Investigational NA-831

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Researchers from NeuroActiva, Inc. presented results of their randomized, double-blind, placebo-controlled phase 2A clinical trial of NA-831.

Depression, Apathy Associated With Increased Risk for Mild Cognitive Impairment

Depression, Apathy Associated With Increased Risk for Mild Cognitive Impairment

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Adults with depressive symptoms and apathy in middle and late life were at a higher risk for conversion to mild cognitive impairment (MCI) and dementia.

Midlife Cognition, Vascular Health Predict Dementia and Cognitive Impairment Later in Life

Midlife Cognition, Vascular Health Predict Dementia and Cognitive Impairment Later in Life

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Investigators reviewed data from patients aged 45 to 64 years who were enrolled in the Atherosclerosis Risk in Communities Study and who attended additional visits for cognitive function evaluation and repeat cardiovascular risk factor assessment.

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

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The findings from the study are limited in generalizability to the dementia-free patient population.

High CSF Neurogranin Associated With Faster Decline in Mild Cognitive Impairment

High CSF Neurogranin Associated With Faster Decline in Mild Cognitive Impairment

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Investigators obtained data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database on patients with normal cognition (n=111) and MCI (n=193), all of whom had CSF Ng samples at baseline as well as memory and executive function evaluations at follow-up.

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

Tau PET a Useful Biomarker for Alzheimer Disease Risk and Progression

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PET imaging may help clinicians track progression of the disease and evaluate response to disease-modifying treatments.

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

Factors Predictive of Mild Cognitive Impairment in Healthy Individuals

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Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.

Cognitive Training May Boost Memory in Mild Cognitive Impairment

Cognitive Training May Boost Memory in Mild Cognitive Impairment

Cognitive training helps to improve memory in older adults with mild cognitive impairment.

Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive Impairment

Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive Impairment

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A lower education level was associated with higher MCI prevalence in 8 of the class I studies.

Obesity and Alzheimer Disease: Exploring Risk Modification

Obesity and Alzheimer Disease: Exploring Risk Modification

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Throughout the life course, higher body mass index and obesity are linked to cognitive decline, brain atrophy, reduced white matter and integrity of the blood-brain barrier, and elevated risk for late-onset Alzheimer disease.

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

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This analysis was comprised of well-educated and mostly white patients, so these findings may be difficult to generalize to all populations.

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

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There is an urgent need for individualized risk assessments for patients with mild cognitive impairment.

Intensive Lifestyle Intervention Holds No Benefit for Cognitive Impairment: Analysis

Intensive Lifestyle Intervention Holds No Benefit for Cognitive Impairment: Analysis

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An intensive lifestyle intervention including diet and exercise resulted in no improvements in cognitive impairment.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

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The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

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Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Mentally Stimulating Activities May Curb Cognitive Decline in Elderly

Mentally Stimulating Activities May Curb Cognitive Decline in Elderly

Engaging in mentally stimulating activities like games, crafting, and computers may help slow cognitive decline in the elderly.

Developing a Model for Predicting Cognitive Impairment in Parkinson's

Developing a Model for Predicting Cognitive Impairment in Parkinson's

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A combination of age and clinical scores better predicted cognitive impairment than age alone.

Solanezumab Fails Primary End Point in Alzheimer's Trial

Solanezumab Fails Primary End Point in Alzheimer's Trial

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Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.

Effect of Antihypertensives, Statins on Cognitive Decline Uncertain

Effect of Antihypertensives, Statins on Cognitive Decline Uncertain

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The effect of antihypertensive drugs and stains on cognition is uncertain.

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

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Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.

Can Loneliness Predict Early Alzheimer's Disease?

Can Loneliness Predict Early Alzheimer's Disease?

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Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.

Cognitive Rehabilitation Intervention Improves Cognition in Cancer Patients

Cognitive Rehabilitation Intervention Improves Cognition in Cancer Patients

There were significantly lower levels of anxiety/depression and fatigue noted in the intervention group.

Aerobic Exercise May Improve Cognition in Vascular Cognitive Impairment

Aerobic Exercise May Improve Cognition in Vascular Cognitive Impairment

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Future studies should explore ways to increase ongoing exercise adherence among participants

Anxiety May Contribute to Memory Problems in Elderly

Anxiety May Contribute to Memory Problems in Elderly

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Anxiety appeared to affect both verbal and visual memory.

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

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Reading and playing games may help reduce MCI risk in non-APOE-ε4 carriers.

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

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Researchers have uncovered a positive synergistic interaction between Alzheimer's pathology and neuropsychiatric symptoms.

Improved Cognitive Assessment Tool for Dementia Screening

Improved Cognitive Assessment Tool for Dementia Screening

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Administration of valid screening measures is vital for the early detection of cognitive impairment.

NIH Launches Research Consortium on Vascular Contributions to Alzheimer's

NIH Launches Research Consortium on Vascular Contributions to Alzheimer's

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The 5-year, $30 million program seeks to identify the molecular connections between vascular risk factors and Alzheimer dementia.

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