Mild Cognitive Impairment

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

Amyloid-Beta Deposition, Decreased Hippocampal Volume Associated with Functional Decline in Elderly

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This analysis was comprised of well-educated and mostly white patients, so these findings may be difficult to generalize to all populations.

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

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There is an urgent need for individualized risk assessments for patients with mild cognitive impairment.

Intensive Lifestyle Intervention Holds No Benefit for Cognitive Impairment: Analysis

Intensive Lifestyle Intervention Holds No Benefit for Cognitive Impairment: Analysis

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An intensive lifestyle intervention including diet and exercise resulted in no improvements in cognitive impairment.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

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The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

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Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Mentally Stimulating Activities May Curb Cognitive Decline in Elderly

Mentally Stimulating Activities May Curb Cognitive Decline in Elderly

Engaging in mentally stimulating activities like games, crafting, and computers may help slow cognitive decline in the elderly.

Developing a Model for Predicting Cognitive Impairment in Parkinson's

Developing a Model for Predicting Cognitive Impairment in Parkinson's

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A combination of age and clinical scores better predicted cognitive impairment than age alone.

Solanezumab Fails Primary End Point in Alzheimer's Trial

Solanezumab Fails Primary End Point in Alzheimer's Trial

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Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.

Effect of Antihypertensives, Statins on Cognitive Decline Uncertain

Effect of Antihypertensives, Statins on Cognitive Decline Uncertain

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The effect of antihypertensive drugs and stains on cognition is uncertain.

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

Preserved Hippocampal Volume in MCI Predicts Progression to Lewy Body Dementia

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Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.

Can Loneliness Predict Early Alzheimer's Disease?

Can Loneliness Predict Early Alzheimer's Disease?

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Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.

Cognitive Rehabilitation Intervention Improves Cognition in Cancer Patients

Cognitive Rehabilitation Intervention Improves Cognition in Cancer Patients

There were significantly lower levels of anxiety/depression and fatigue noted in the intervention group.

Aerobic Exercise May Improve Cognition in Vascular Cognitive Impairment

Aerobic Exercise May Improve Cognition in Vascular Cognitive Impairment

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Future studies should explore ways to increase ongoing exercise adherence among participants

Anxiety May Contribute to Memory Problems in Elderly

Anxiety May Contribute to Memory Problems in Elderly

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Anxiety appeared to affect both verbal and visual memory.

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

Mentally Stimulating Activities May Lower Risk of Mild Cognitive Impairment

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Reading and playing games may help reduce MCI risk in non-APOE-ε4 carriers.

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

Depression, Anxiety Plus Amyloid Pathology Elevates MCI Risk

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Researchers have uncovered a positive synergistic interaction between Alzheimer's pathology and neuropsychiatric symptoms.

Improved Cognitive Assessment Tool for Dementia Screening

Improved Cognitive Assessment Tool for Dementia Screening

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Administration of valid screening measures is vital for the early detection of cognitive impairment.

NIH Launches Research Consortium on Vascular Contributions to Alzheimer's

NIH Launches Research Consortium on Vascular Contributions to Alzheimer's

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The 5-year, $30 million program seeks to identify the molecular connections between vascular risk factors and Alzheimer dementia.

Does Cognitive Reserve Play a Role in Mild Cognitive Impairment?

Does Cognitive Reserve Play a Role in Mild Cognitive Impairment?

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Researchers sought to understand sex differences in verbal memory deficits and its relationship to hippocampal volume.

Metabolic Syndrome Tied to Mild Cognitive Impairment, Dementia Risk

Metabolic Syndrome Tied to Mild Cognitive Impairment, Dementia Risk

Risk of MCI was increased with baseline characteristics of metabolic syndrome.

Hostility, Stress in Young Adults Increases Risk of Memory Problems in Middle Age

Hostility, Stress in Young Adults Increases Risk of Memory Problems in Middle Age

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Those with the highest levels of hostility and stress at baseline recalled .16 and .30 fewer words respectively in middle age.

Few Middle-Age Adults Discuss Memory Complaints

Few Middle-Age Adults Discuss Memory Complaints

Only 25.2 percent of adults aged 45 and older reported memory complaints to healthcare professionals.

Midlife Weight Loss May Increase Mild Cognitive Impairment Risk

Midlife Weight Loss May Increase Mild Cognitive Impairment Risk

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Research indicates that a loss of weight beginning in midlife and continuing into late life increases risk of MCI.

Stress Associated with Increased Risk of Mild Cognitive Impairment

Stress Associated with Increased Risk of Mild Cognitive Impairment

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Those with the highest stress level were more likely to be female, less educated, and more depressed.

BRCA1 May Play Role in Neurodegeneration

BRCA1 May Play Role in Neurodegeneration

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The pathological accumulation of beta-amyloid may contribute to deficits in levels of BRCA1.

Elevated Amyloid Levels Point to Increased Risk of Cognitive Decline

Elevated Amyloid Levels Point to Increased Risk of Cognitive Decline

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PiB status alone was predictive of cognitive decline associated with MCI.

Worsening Sense of Smell Linked to Mild Cognitive Impairment, Dementia

Worsening Sense of Smell Linked to Mild Cognitive Impairment, Dementia

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Worsening scores on the smell test were associated with greater risk of mild cognitive impairment and Alzheimer's disease dementia.

Neurogranin Shows Promise as Biomarker for Alzheimer's

Neurogranin Shows Promise as Biomarker for Alzheimer's

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Patients who progressed from MCI to Alzheimer's had lower levels of neurogranin than those who remained stable.

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