Mild Cognitive Impairment
Researchers from NeuroActiva, Inc. presented results of their randomized, double-blind, placebo-controlled phase 2A clinical trial of NA-831.
Adults with depressive symptoms and apathy in middle and late life were at a higher risk for conversion to mild cognitive impairment (MCI) and dementia.
Investigators reviewed data from patients aged 45 to 64 years who were enrolled in the Atherosclerosis Risk in Communities Study and who attended additional visits for cognitive function evaluation and repeat cardiovascular risk factor assessment.
The findings from the study are limited in generalizability to the dementia-free patient population.
Investigators obtained data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) database on patients with normal cognition (n=111) and MCI (n=193), all of whom had CSF Ng samples at baseline as well as memory and executive function evaluations at follow-up.
PET imaging may help clinicians track progression of the disease and evaluate response to disease-modifying treatments.
Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.
Cognitive training helps to improve memory in older adults with mild cognitive impairment.
Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive ImpairmentJanuary 15, 2018
A lower education level was associated with higher MCI prevalence in 8 of the class I studies.
Throughout the life course, higher body mass index and obesity are linked to cognitive decline, brain atrophy, reduced white matter and integrity of the blood-brain barrier, and elevated risk for late-onset Alzheimer disease.
This analysis was comprised of well-educated and mostly white patients, so these findings may be difficult to generalize to all populations.
There is an urgent need for individualized risk assessments for patients with mild cognitive impairment.
An intensive lifestyle intervention including diet and exercise resulted in no improvements in cognitive impairment.
The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.
Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.
Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.
Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.
Engaging in mentally stimulating activities like games, crafting, and computers may help slow cognitive decline in the elderly.
A combination of age and clinical scores better predicted cognitive impairment than age alone.
Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.
The effect of antihypertensive drugs and stains on cognition is uncertain.
Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.
Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.
There were significantly lower levels of anxiety/depression and fatigue noted in the intervention group.
Future studies should explore ways to increase ongoing exercise adherence among participants
Anxiety appeared to affect both verbal and visual memory.
Reading and playing games may help reduce MCI risk in non-APOE-ε4 carriers.
Researchers have uncovered a positive synergistic interaction between Alzheimer's pathology and neuropsychiatric symptoms.
Administration of valid screening measures is vital for the early detection of cognitive impairment.
The 5-year, $30 million program seeks to identify the molecular connections between vascular risk factors and Alzheimer dementia.
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