Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status
There were no significant differences in voxel-wise contrasts of whole-brain tau PET uptake between patients with PD-CN and PD-MCI.
HealthDay News — Patterns of cortical β-amyloid (Aβ) and tau are not different for patients with Parkinson disease (PD) who are cognitively normal (PD-CN) or with mild cognitive impairment (MCI) and for healthy adults, according to a study published online in JAMA Neurology.
Joseph R. Winer, from the University of California in Berkeley, and colleagues conducted a cross-sectional study involving 29 patients with PD (15 with PD-CN and 14 with PD-MCI) and 49 healthy controls to compare tau positron emission tomographic (PET) measurements.
The researchers found that 6 PD patients were Aβ-positive, of whom one had PD-MCI, and 23 patients were Aβ-negative.
There were no significant differences in voxel-wise contrasts of whole-brain tau PET uptake between patients with PD-CN and PD-MCI, or for all patients with PD vs Aβ-negative controls. There were no differences in tau PET binding between patients with PD-MCI and PC-CN in brain regions reflecting Alzheimer disease Braak stages 1/2, 3/4, or 5/6, nor was there any difference from Aβ-negative healthy older adults. In Aβ-positive patients with PD there was significantly elevated tau PET binding relative to Aβ-negative patients with PD within brain regions reflecting Alzheimer disease Braak stage 3/4 and Braak stage 5/6.
"Age, Aβ, and tau do not differentiate patients with PD-CN and PD-MCI," the authors write. "Cognitive deficits in people with PD without dementia do not appear to reflect measureable Alzheimer disease."
Two authors disclosed financial ties to the pharmaceutical industry; Avid Radiopharmaceuticals enabled use of the [18F] AV-1451 tracer.
Winer JR, Maass A, Pressman P, et al. Associations between Tau, β-Amyloid, and cognition in Parkinson disease [published online December 11, 2017]. JAMA Neurol. doi:10.1001/jamaneurol.2017.3713