Movement Disorders

Several Factors May Predict Cognitive Decline in Parkinson's Disease

Several Factors May Predict Cognitive Decline in Parkinson's Disease

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Dopamine deficiency, decreases in cortical thickness and volume in certain areas of the brain was predictive of cognitive decline.

Extended-Release Amantadine Reduces Levodopa-Induced Dyskinesia in Parkinson's Disease

Extended-Release Amantadine Reduces Levodopa-Induced Dyskinesia in Parkinson's Disease

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Patients in the treatment group had improved ON and OFF times and no worsening of motor function.

Neurofilament Light Protein Shows Strong Potential as Biomarker for Huntington's Disease

Neurofilament Light Protein Shows Strong Potential as Biomarker for Huntington's Disease

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Investigators examined blood plasma samples taken annually from a cohort of 201 huntingtin gene (HTT) carriers.

Identifying Prodromal Symptoms of Ataxia Type 2 for Early Intervention

Identifying Prodromal Symptoms of Ataxia Type 2 for Early Intervention

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Investigators identified a series of prodromal signs that appear anywhere from 1 to 18 years before a clinical diagnosis of SCA2.

Risk for Death Significantly Increased in Patients With Synucleinopathies

Risk for Death Significantly Increased in Patients With Synucleinopathies

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Patients with multiple system atrophy with parkinsonism face the greatest risk for death among synucleinopathies.

No Link Between Parkinson's, Overall Vagotomy

No Link Between Parkinson's, Overall Vagotomy

However, there is a trend toward lower risk of Parkinson's for patients with truncal vagotomy.

MRI-Guided Focused Ultrasound More Cost Effective Treatment for Essential Tremor

MRI-Guided Focused Ultrasound More Cost Effective Treatment for Essential Tremor

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MRI-guided focused ultrasound thalamotomy is more effective than deep brain stimulation and significantly cheaper.

Electroconvulsive Therapy May Benefit Patients With Huntington's Disease

Electroconvulsive Therapy May Benefit Patients With Huntington's Disease

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Electroconvulsive therapy might be safe and reliable therapy for treatment of psychiatric symptoms in patients with Huntington Disease

Treating Tardive Dyskinesia in Schizophrenia

Treating Tardive Dyskinesia in Schizophrenia

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Long-term valbenazine may be beneficial in managing tardive dyskinesia in schizophrenia.

What to Expect: International Congress of Parkinson's Disease and Movement Disorders 2017

What to Expect: International Congress of Parkinson's Disease and Movement Disorders 2017

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Learn more about what to expect from this year's International Congress of Parkinson's Disease and Movement Disorders.

Treating Tardive Dyskinesia Without Disrupting Psychiatric Treatment

Treating Tardive Dyskinesia Without Disrupting Psychiatric Treatment

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Joohi Jimenez-Shahed, MD, discusses her research on the use of deutetrabenazine for the treatment of tardive dyskinesia in patients taking concomitant antipsychotics or neuroleptics. Scroll below the video for the full transcript.

New Clinical Guidelines: Distinguishing Variations of Progressive Supranuclear Palsy

New Clinical Guidelines: Distinguishing Variations of Progressive Supranuclear Palsy

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New guidelines for progressive supranuclear palsy provide very specific and sensitive criteria that allow for identification of clinical features of the disease at much earlier stages.

Parkinson-Related Dyskinesia May Respond to Dextromethorphan, Quinidine Combo

Parkinson-Related Dyskinesia May Respond to Dextromethorphan, Quinidine Combo

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Dextromethorphan is thought to have an impact on all 3 therapeutic pathways for dyskinesia.

An Interdisciplinary Approach to Advanced Parkinson's Care

An Interdisciplinary Approach to Advanced Parkinson's Care

Jori Fleisher, MD, MSCE, of New York University School of Medicine, discusses her research on an interdisciplinary home visit program for patients with advanced Parkinson's disease. Scroll below the video for the full transcript.

Tourette Syndrome Linked to De Novo Coding Variants

Tourette Syndrome Linked to De Novo Coding Variants

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De novo likely gene disrupting variants were highly overrepresented in the Tourette's cases compared with unaffected parent and sibling sample controls.

Severe Tourette's May Benefit From Deep Brain Stimulation

Severe Tourette's May Benefit From Deep Brain Stimulation

The results add to the growing body of evidence in support of deep brain stimulation for refractory Tourette syndrome.

Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness

Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness

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A patient should be notified of the possibility of developing an ICD before initiating any dopaminergic treatment for PD, particularly dopamine agonists.

Parkinson's Disease Off Time Reduced With Apomorphine

Parkinson's Disease Off Time Reduced With Apomorphine

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A 150-year-old drug, apomorphine, may reduce off time in patients with Parkinson's disease.

Adjunct Medical Food Holds Benefits for Parkinson's Disease

Adjunct Medical Food Holds Benefits for Parkinson's Disease

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Previous animal model studies have shown PEA to be beneficial in neuroinflammation and provide neuroprotection.

Dizziness in Parkinson's May Be Caused by Cerebral Hypoperfusion

Dizziness in Parkinson's May Be Caused by Cerebral Hypoperfusion

Transcranial Doppler during head-up tilting may be useful for evaluating dizziness.

Parkinson's Disease Linked to Hepatitis B, C Infection

Parkinson's Disease Linked to Hepatitis B, C Infection

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People with HBV were 76% more likely and those with HCV were 51% more likely to develop PD than people in the comparison group.

Tardive Dyskinesia Treatment Approved by FDA

Tardive Dyskinesia Treatment Approved by FDA

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Valbenazine is the first drug approved for the treatment of tardive dyskinesia, an adverse effect associated with the use of some antipsychotic medications.

Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease

Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease

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A significant association was found between the apnea-hypopnea index and Epworth Sleepiness Scale scores.

Novel Assay Identifies Parkinson's Disease Biomarker

Novel Assay Identifies Parkinson's Disease Biomarker

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Researchers have developed an assay that accurately identifies small quantities of α-synuclein in cerebrospinal fluid.

Regular Exercise Slows Decline Even in Advanced Parkinson's

Regular Exercise Slows Decline Even in Advanced Parkinson's

There were slower declines in health-related quality of life and mobility when exercise was increased by 30 minutes/week.

Safinamide Approved as Adjunctive Therapy for Parkinson's

Safinamide Approved as Adjunctive Therapy for Parkinson's

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The US FDA has approved safinamide as adjunctive therapy in Parkinson's disease to increase "on" time

Movement Disorder After Foreign Body Ingestion

Movement Disorder After Foreign Body Ingestion

A 10-month-old girl admitted to PICU with sudden onset of movement disorder was found to have ingested a foreign body.

Cerebral Palsy in Full-Term Infants Linked to Maternal Obesity

Cerebral Palsy in Full-Term Infants Linked to Maternal Obesity

While their are other factors more strongly associated with risk of cerebral palsy, maternal obesity is modifiable and therefore should be studied further.

Timed Light Therapy May Benefit Sleep in Parkinson's

Timed Light Therapy May Benefit Sleep in Parkinson's

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Improvements in excessive daytime sleepiness and daytime alertness were observed in the bright light therapy group.

Parkinsonian Disorder Differentiation Using Blood Biomarker

Parkinsonian Disorder Differentiation Using Blood Biomarker

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Neurofilament light chain, a blood biomarker, demonstrated high accuracy for distinguishing atypical parkinsonian disorders from Parkinson's disease.

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