Movement Disorders

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

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Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

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Patients with TBI had a higher incidence of PD compared with patients without TBI.

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

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Using information from these assessments, investigators identified participants as having either major psychotic symptoms, isolated minor psychotic symptoms, or no psychotic symptoms.

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

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Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

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The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.

IBD Associated With Increased Incidence of Parkinson Disease

IBD Associated With Increased Incidence of Parkinson Disease

Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

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Previous research has suggested a genetic and functional link between IBD and PD, however evidence regarding this association has been limited.

Mild TBI May Increase Risk of Parkinson Disease

Mild TBI May Increase Risk of Parkinson Disease

Mild traumatic brain injury is associated with increased risk of Parkinson disease among military veterans.

Long-Term Benefits of Gocovri Observed in PD Patients With Dyskinesia

Long-Term Benefits of Gocovri Observed in PD Patients With Dyskinesia

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By 2 years, 30% of patients had increased their levodopa dose by ~300mg, indicating that treatment with Gocovri may allow for further levodopa optimization despite the occurrence of dyskinesia.

Dyskinesia, Psychiatric Disorders Associated With Functional Neurological Symptoms in PD

Dyskinesia, Psychiatric Disorders Associated With Functional Neurological Symptoms in PD

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Investigators conducted a review of electronic medical records to assess functional neurologic disorders in patients with Parkinson disease.

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

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Wearable technology may help monitor on/off states in patients with Parkinson disease in an outpatient setting.

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

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Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

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In this article, we explore research findings to provide a deeper understanding of the factors associated with increased risk for impulse control disorders in Parkinson disease. Deputy Director of the Parkinson's UK charity, Professor David Dexter, also provides insights on the mechanisms of impulse control disorders and the implications of new findings on the management of Parkinson disease.

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

Connection Between Essential Tremor, Depression Remains Unclear

Connection Between Essential Tremor, Depression Remains Unclear

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Approximately 20% of patients in this cohort were considered clinically depressed based on GDS criteria.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

Extended Release Amantadine Effective for Reducing Dyskinesia in Parkinson Disease

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ADS-5102 is a promising treatment option: if taken once daily at night, it achieves highest plasma drug concentrations throughout the day when symptoms are most bothersome.

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

Progressive Supranuclear Palsy: Pedunculopontine Nucleus DBS May Not Improve Symptoms

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Seven patients with progressive supranuclear palsy received bilateral pedunculopontine nucleus deep brain stimulation at frequencies of 8, 20, 60, and 130 Hz.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

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Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

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Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

Old Challenges and New Directions in Managing Tardive Dyskinesia

Old Challenges and New Directions in Managing Tardive Dyskinesia

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"Since the current generation of psychiatrists has been raised on second-generation antipsychotics and has relatively little experience with first-generation antipsychotics, keeping tardive dyskinesia in mind is not, on the whole, part of their experience or training," said Christoph U. Correll, MD.

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

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Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

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Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

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Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Palliative Care in Movement Disorders: Recommendations for Improvement

Palliative Care in Movement Disorders: Recommendations for Improvement

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Parkinsonism syndromes are associated with progressive disability and increased mortality, with symptom burden comparable to that of advanced cancer.

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