Movement Disorders

New Clinical Guidelines: Distinguishing Variations of Progressive Supranuclear Palsy

New Clinical Guidelines: Distinguishing Variations of Progressive Supranuclear Palsy

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New guidelines for progressive supranuclear palsy provide very specific and sensitive criteria that allow for identification of clinical features of the disease at much earlier stages.

Parkinson-Related Dyskinesia May Respond to Dextromethorphan, Quinidine Combo

Parkinson-Related Dyskinesia May Respond to Dextromethorphan, Quinidine Combo

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Dextromethorphan is thought to have an impact on all 3 therapeutic pathways for dyskinesia.

An Interdisciplinary Approach to Advanced Parkinson's Care

An Interdisciplinary Approach to Advanced Parkinson's Care

Jori Fleisher, MD, MSCE, of New York University School of Medicine, discusses her research on an interdisciplinary home visit program for patients with advanced Parkinson's disease. Scroll below the video for the full transcript.

Tourette Syndrome Linked to De Novo Coding Variants

Tourette Syndrome Linked to De Novo Coding Variants

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De novo likely gene disrupting variants were highly overrepresented in the Tourette's cases compared with unaffected parent and sibling sample controls.

Severe Tourette's May Benefit From Deep Brain Stimulation

Severe Tourette's May Benefit From Deep Brain Stimulation

The results add to the growing body of evidence in support of deep brain stimulation for refractory Tourette syndrome.

Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness

Impulse Control Disorders in Parkinson's Disease: Building Physician, Patient Awareness

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A patient should be notified of the possibility of developing an ICD before initiating any dopaminergic treatment for PD, particularly dopamine agonists.

Parkinson's Disease Off Time Reduced With Apomorphine

Parkinson's Disease Off Time Reduced With Apomorphine

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A 150-year-old drug, apomorphine, may reduce off time in patients with Parkinson's disease.

Adjunct Medical Food Holds Benefits for Parkinson's Disease

Adjunct Medical Food Holds Benefits for Parkinson's Disease

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Previous animal model studies have shown PEA to be beneficial in neuroinflammation and provide neuroprotection.

Dizziness in Parkinson's May Be Caused by Cerebral Hypoperfusion

Dizziness in Parkinson's May Be Caused by Cerebral Hypoperfusion

Transcranial Doppler during head-up tilting may be useful for evaluating dizziness.

Parkinson's Disease Linked to Hepatitis B, C Infection

Parkinson's Disease Linked to Hepatitis B, C Infection

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People with HBV were 76% more likely and those with HCV were 51% more likely to develop PD than people in the comparison group.

Tardive Dyskinesia Treatment Approved by FDA

Tardive Dyskinesia Treatment Approved by FDA

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Valbenazine is the first drug approved for the treatment of tardive dyskinesia, an adverse effect associated with the use of some antipsychotic medications.

Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease

Obstructive Sleep Apnea Affects Cognition in Parkinson's Disease

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A significant association was found between the apnea-hypopnea index and Epworth Sleepiness Scale scores.

Novel Assay Identifies Parkinson's Disease Biomarker

Novel Assay Identifies Parkinson's Disease Biomarker

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Researchers have developed an assay that accurately identifies small quantities of α-synuclein in cerebrospinal fluid.

Regular Exercise Slows Decline Even in Advanced Parkinson's

Regular Exercise Slows Decline Even in Advanced Parkinson's

There were slower declines in health-related quality of life and mobility when exercise was increased by 30 minutes/week.

Safinamide Approved as Adjunctive Therapy for Parkinson's

Safinamide Approved as Adjunctive Therapy for Parkinson's

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The US FDA has approved safinamide as adjunctive therapy in Parkinson's disease to increase "on" time

Movement Disorder After Foreign Body Ingestion

Movement Disorder After Foreign Body Ingestion

A 10-month-old girl admitted to PICU with sudden onset of movement disorder was found to have ingested a foreign body.

Cerebral Palsy in Full-Term Infants Linked to Maternal Obesity

Cerebral Palsy in Full-Term Infants Linked to Maternal Obesity

While their are other factors more strongly associated with risk of cerebral palsy, maternal obesity is modifiable and therefore should be studied further.

Timed Light Therapy May Benefit Sleep in Parkinson's

Timed Light Therapy May Benefit Sleep in Parkinson's

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Improvements in excessive daytime sleepiness and daytime alertness were observed in the bright light therapy group.

Parkinsonian Disorder Differentiation Using Blood Biomarker

Parkinsonian Disorder Differentiation Using Blood Biomarker

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Neurofilament light chain, a blood biomarker, demonstrated high accuracy for distinguishing atypical parkinsonian disorders from Parkinson's disease.

Effect of Depression and Anxiety on Cognition in Parkinson's Disease

Effect of Depression and Anxiety on Cognition in Parkinson's Disease

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Comorbid psychological conditions affect cognitive function in Parkinson's disease, and treatment can be complicated by overlapping symptoms.

VIDEO: Dysfunctional Mitochondrial DNA May Play a Role in Parkinson's Disease

VIDEO: Dysfunctional Mitochondrial DNA May Play a Role in Parkinson's Disease

New findings suggest that dysregulation of mitochondrial DNA homeostasis may be a key factor in the pathogenesis of neuronal loss in people with Parkinson's disease.

Cognitive Stress Impacts Levodopa Efficacy in Parkinson's

Cognitive Stress Impacts Levodopa Efficacy in Parkinson's

During cognitive co-activation, the levodopa effect was significantly smaller.

FDA Reviewing Potential Treatment for Levodopa-Induced Dyskinesia

FDA Reviewing Potential Treatment for Levodopa-Induced Dyskinesia

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The FDA has accepted the NDA for ADS-5102 for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.

Developing a Model for Predicting Cognitive Impairment in Parkinson's

Developing a Model for Predicting Cognitive Impairment in Parkinson's

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A combination of age and clinical scores better predicted cognitive impairment than age alone.

Adjunctive Safinamide Increases On Time in Parkinson's Disease

Adjunctive Safinamide Increases On Time in Parkinson's Disease

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Adjunctive treatment with safinamide helps increase "on" time in patients with Parkinson's disease.

Gene Mutation, Age Linked to Early-Onset Parkinson's Disease

Gene Mutation, Age Linked to Early-Onset Parkinson's Disease

Mutated GCH1 gene was associated with a 23% increased risk of Parkinson's disease, especially in men 50 years or younger.

More Evidence Favoring Inhaled Levodopa for Parkinson's

More Evidence Favoring Inhaled Levodopa for Parkinson's

A powdered version of the common treatment may help to relieve "off" periods.

Parkinson's Intestinal Gel May Cause Nerve Damage

Parkinson's Intestinal Gel May Cause Nerve Damage

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The small study documented several cases of denervation and increased thermal thresholds in patients treated with LCIG.

Whole Body Vibration, Exercise May Improve Motor Performance In Parkinson's

Whole Body Vibration, Exercise May Improve Motor Performance In Parkinson's

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Pharmacologic intervention is the current standard of care for Parkinson's disease, yet medications frequently fail to control some symptoms, including tremor and postural instability.

GBA Mutations in Parkinson's May Increase Risk of Dementia

GBA Mutations in Parkinson's May Increase Risk of Dementia

The researchers found that GBA carriers were at greater risk for dementia and death (hazard ratios, 3.16 and 1.85, respectively) than non-carriers.

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