A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.
By 10 weeks, participants in the treatment group reported significant improvements in quality of life.
Utilizing 123I-FP-CIT SPECT imaging of raphe serotonergic nuclei and putamen dopaminergic terminals may help detect factors that influence response to dopaminergic treatment.
Anesthetic medications have been identified as a potential cause of morbidity in this population due to their interaction with the drugs used to manage Parkinson disease.
Although treatment with botulinum toxin is effective for pain and posturing associated with cervical dystonia, myoclonus and tremor remain difficult to treat and contribute to compromised quality of life for patients with this movement disorder.
Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.
The investigators excluded non-responders to MRgFUS, which may have produced an overestimate of the therapy's benefit in the remaining patients.
The ParkinsonNet network was associated with reduced overall health care costs.
The neuroprotective effect of caffeine has previously been examined in epidemiologic studies.
Adamas announced that Gocovri extended-release capsules are now available for the treatment of dyskinesia in Parkinson's patients.
In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.
The incidence of impulsive compulsive behaviors in patients with Parkinson's may be related to excessive stimulation of dopamine.
Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.
The findings suggest that efforts to help prevent anxiety may help reduce risk for gait freezing.
In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.
Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.
High-intensity treadmill exercise appears to be a safe and tolerable option for physical activity in patients with Parkinson disease.
Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.
The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.
Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.
Patient's with depression that have Parkinson's disease have impaired white matter integrity.
More men with Parkinson's disease have caregivers than women.
Investigators analyzed data for baseline factors that may influence weight loss in early parkinson's disease.
Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.
The efficacy of focused ultrasound thalamotomy was evaluated for management of medically refractory, tremor-dominant Parkinson disease.
Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.
Ingrezza was well-tolerated in patients with tardive dyskinesia.
Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.
There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.
Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.
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