Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.
Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.
Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.
Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.
Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.
Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.
Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.
The Parkinson's Foundation Prevalence Project estimates that within the next 2 years, 930,000 people in the United States will be living with the condition; that number is anticipated to rise to 1.2 million by 2030.
Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.
Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.
Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.
Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.
There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.
For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.
A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.
Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.
Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.
The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive StrategiesJune 12, 2018
More than half of patients diagnosed with Parkinson disease experience freezing of gait.
A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.
Individuals with Tourette syndrome or chronic tic disorders have lower likelihood of academic achievement.
Surgical interventions for Parkinson disease are experiencing a swell in innovation, thanks in part to the entry of two additional medical device companies into a field previously dominated by one company.
There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.
Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.
Patients with TBI had a higher incidence of PD compared with patients without TBI.
Using information from these assessments, investigators identified participants as having either major psychotic symptoms, isolated minor psychotic symptoms, or no psychotic symptoms.
Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.
Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.
The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.
Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.
Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.
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