Movement Disorders

FDA Reviewing Potential Treatment for Levodopa-Induced Dyskinesia

FDA Reviewing Potential Treatment for Levodopa-Induced Dyskinesia

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The FDA has accepted the NDA for ADS-5102 for the treatment of levodopa-induced dyskinesia (LID) in patients with Parkinson's disease.

Developing a Model for Predicting Cognitive Impairment in Parkinson's

Developing a Model for Predicting Cognitive Impairment in Parkinson's

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A combination of age and clinical scores better predicted cognitive impairment than age alone.

Adjunctive Safinamide Increases On Time in Parkinson's Disease

Adjunctive Safinamide Increases On Time in Parkinson's Disease

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Adjunctive treatment with safinamide helps increase "on" time in patients with Parkinson's disease.

Gene Mutation, Age Linked to Early-Onset Parkinson's Disease

Gene Mutation, Age Linked to Early-Onset Parkinson's Disease

Mutated GCH1 gene was associated with a 23% increased risk of Parkinson's disease, especially in men 50 years or younger.

More Evidence Favoring Inhaled Levodopa for Parkinson's

More Evidence Favoring Inhaled Levodopa for Parkinson's

A powdered version of the common treatment may help to relieve "off" periods.

Parkinson's Intestinal Gel May Cause Nerve Damage

Parkinson's Intestinal Gel May Cause Nerve Damage

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The small study documented several cases of denervation and increased thermal thresholds in patients treated with LCIG.

Whole Body Vibration, Exercise May Improve Motor Performance In Parkinson's

Whole Body Vibration, Exercise May Improve Motor Performance In Parkinson's

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Pharmacologic intervention is the current standard of care for Parkinson's disease, yet medications frequently fail to control some symptoms, including tremor and postural instability.

GBA Mutations in Parkinson's May Increase Risk of Dementia

GBA Mutations in Parkinson's May Increase Risk of Dementia

The researchers found that GBA carriers were at greater risk for dementia and death (hazard ratios, 3.16 and 1.85, respectively) than non-carriers.

Statin Therapy Recommended in Parkinson's Patients With Vascular Risks

Statin Therapy Recommended in Parkinson's Patients With Vascular Risks

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Vascular disease can have a negative impact on cognition and motor phenotype in PD.

Cognitive Training, Transcranial Direct Current Stimulation Improves Cognition in Parkinson's

Cognitive Training, Transcranial Direct Current Stimulation Improves Cognition in Parkinson's

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Cognitive training and tDCS, alone or combined, appear to benefit cognition and QOL in Parkinson's patients

Gait Characteristics Better Predict Cognitive Decline in Early Parkinson's

Gait Characteristics Better Predict Cognitive Decline in Early Parkinson's

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The standard MoCA evaluation was unable to predict decline in fluctuating attention and visual memory.

Alternative Therapies Deemed Effective for Parkinson's Symptoms

Alternative Therapies Deemed Effective for Parkinson's Symptoms

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Over fifty percent of respondents reported using 1 or more alternative therapies.

4th World Parkinson Congress: What to Expect

4th World Parkinson Congress: What to Expect

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The 4th World Parkinson Congress takes September 20-23, 2016 in Portland, Oregon.

GBA Variants Predict Rapid Progression of Parkinson's Disease

GBA Variants Predict Rapid Progression of Parkinson's Disease

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The pathogenesis of GBA on PD is unclear, although several studies have pointed to disruptions of different molecular pathways that contribute to disease onset.

Nicotine Exposure During Pregnancy Linked to Tourette Syndrome in Children

Nicotine Exposure During Pregnancy Linked to Tourette Syndrome in Children

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Smoking during pregnancy has been linked withlong-term neurodevelopmental abnormalities and child behavioral problems.

MRI-Guided Focused Ultrasound Thalamotomy Improves Essential Tremor

MRI-Guided Focused Ultrasound Thalamotomy Improves Essential Tremor

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Patients in the treatment group experienced significant improvements at 3 months and through 12 months.

Beneficial Effect on Cognition Noted With Music Therapy in PD

Beneficial Effect on Cognition Noted With Music Therapy in PD

The potential role of active music therapy in ameliorating motor and nonmotor symptoms of Parkinson's disease (PD) was examined by researchers.

Statins May Protect Against Parkinson's Disease in Diabetes

Statins May Protect Against Parkinson's Disease in Diabetes

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All but one type of statin was associated with a dose-dependent neurprotective benefit against Parkinson's.

Differential Diagnosis: Tic Disorders vs Myoclonic Epilepsy

Differential Diagnosis: Tic Disorders vs Myoclonic Epilepsy

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Myoclonic seizures may be easily mistaken for a possible tic disorder if the proper patient monitoring is not conducted during diagnosis.

When It's Not Alzheimer's: The Differential Diagnosis of Dementia With Lewy Bodies

When It's Not Alzheimer's: The Differential Diagnosis of Dementia With Lewy Bodies

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According to a 2010 report based on a survey of caregivers of people with DLB, 78% of cases were initially misdiagnosed.

Leukemia Drug May Have Benefits for Parkinson's Disease

Leukemia Drug May Have Benefits for Parkinson's Disease

The drug was generally well-tolerated among study participants.

FDA Approves First Focused Ultrasound Treatment for Essential Tremor

FDA Approves First Focused Ultrasound Treatment for Essential Tremor

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Patients experienced a 50% improvement in tremor and motor function.

Exposure to Gadolinium Via MRI Not Linked to Parkinsonism

Exposure to Gadolinium Via MRI Not Linked to Parkinsonism

The FDA previously investigated the effects of gadolinium deposits in the brain.

Novel Therapy May Improve Chorea Symptoms in Huntington's Disease

Novel Therapy May Improve Chorea Symptoms in Huntington's Disease

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The drug has a similar mechanism of action as tetrabenazine, but a different pharmacokinetic profile.

Antipsychotics May Elevate Risk of Movement Disorders

Antipsychotics May Elevate Risk of Movement Disorders

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The odd relationship may have more to do with the mental disorder than the drugs.

Parkinson's Incidence On the Rise, but Source is Unclear

Parkinson's Incidence On the Rise, but Source is Unclear

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Critics are warning to not jump to conclusions, as the results may stem from several causes.

FDA Approves Nuplazid for Parkinson's Disease Psychosis

FDA Approves Nuplazid for Parkinson's Disease Psychosis

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The drug is the first of its kind to address PD psychosis without having an ill effect on motor symptoms.

Updated Treatment Guidelines for the Use of Botulinum Toxin in Spasticity, Headache

Updated Treatment Guidelines for the Use of Botulinum Toxin in Spasticity, Headache

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Treatment of chronic, but not episodic migraine with botulinum toxin has been added to the treatment guidelines.

Link Observed Between GBA Mutations and REM Sleep Behavior Disorder

Link Observed Between GBA Mutations and REM Sleep Behavior Disorder

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Glucocerebrosidase gene mutation has been found to be strongly associated with REM sleep behavior disorder.

Long-Term Lithium Treatment Linked to Increased Dopaminergic Drug Use

Long-Term Lithium Treatment Linked to Increased Dopaminergic Drug Use

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The authors are primarily concerned with the overlap of therapies being used in these patients.

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