Movement Disorders

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

By

Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.

<i>LRP10</i> Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

LRP10 Gene Variants Implicated in Parkinson Disease, Lewy Body Dementia

By

Mutations in the LRP10 gene appear to be common in patients with inherited α-synucleinopathies.

Changes in Glucose Regulation in Parkinson Disease

Changes in Glucose Regulation in Parkinson Disease

By

Investigators sought to determine whether patients with moderate to advanced Parkinson disease have impaired glucose levels during an Oral Glucose Tolerance Test.

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

Targeted Gene Panel May Be More Effective for Identifying Movement Disorders

By

Investigators developed and evaluated a targeted sequencing approach using a panel of genes involved in movement disorders.

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

Medical Cannabis Promising for Dystonia Improvement in Pediatric Motor Disorders

By

Children with a complex motor disorder, characterized by a combination of movement and posture abnormalities (eg, spasticity and dystonia), were enrolled.

 Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

Globus Pallidus Interna DBS Improves Function in Refractory Meige Syndrome

By

Meige syndrome is a craniofacial dystonia characterized by involuntary muscle contractions of the jaw and around the eyes.

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

Worse Outcomes With Dyskinesia Than With Spasticity in Cerebral Palsy

By

Across the entire cohort, the predominant motor types featured were 70% spastic, 22% dyskinetic (21% dystonic and 1% choreoathetotic), 6% hypotonic, and 2% ataxic.

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

Parkinson Disease Prevalence Severely Underestimated: Parkinson's Foundation Prevalence Project

By

The Parkinson's Foundation Prevalence Project estimates that within the next 2 years, 930,000 people in the United States will be living with the condition; that number is anticipated to rise to 1.2 million by 2030.

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

Researchers Identify Demographic, Clinical Variables of Oromandibular Dystonia

By

Researchers collected and analyzed data on age at onset, sex, family history of dystonia, and the presence of associated anatomic sites with dystonia.

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

Screening Tool Differentiates Progressive Supranuclear Palsy and Parkinson Disease

By

Investigators sought to determine if the ECAS diagnostic screening tool is sufficiently sensitive to distinguish between progressive supranuclear palsy and Parkinson disease.

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

Exercise Does Not Impact Gait or Signal Changes in Freezing and Nonfreezing Parkinson Disease

By

Study investigators enrolled a total of 37 patients with PD who had participated in a larger prospective, controlled exercise study.

FDA Approves New Pimavanserin Formulation, Dosage Strength

FDA Approves New Pimavanserin Formulation, Dosage Strength

By

Nuplazid, a non-dopaminergic, selective serotonin inverse agonist, targets 5-HT2A receptors that are thought to be involved in Parkinson's disease psychosis.

Strong Link Identified Between T2DM and Parkinson Disease

Strong Link Identified Between T2DM and Parkinson Disease

There is an increased rate of subsequent Parkinson disease among individuals diagnosed with type 2 diabetes mellitus.

Parkinson's Medications Tied to Impulse Control Disorders

Parkinson's Medications Tied to Impulse Control Disorders

For patients with Parkinson disease, dopamine agonist use is associated with incidence of impulse control disorders in a dose-effect relationship.

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

Focal Brain Atrophy Predicts Cognitive Decline in Parkinson Disease After DBS

By

A total of 42 consecutive patients with PD who underwent STN-DBS were enrolled in this study.

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

FDA to Review Sublingual Tx for Motor Fluctuations in Parkinson Disease

By

Sunovion announced that the FDA has accepted the NDA for apomorphine sublingual film to treat motor fluctuations seen in patients with Parkinson's.

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

Disrupted Thalamo-Striato-Hypothalamic Function May Serve as a Good Biomarker for Parkinson Disease

By

Investigators tested functional connectivity between the right and left hypothalamus as well as the other brain regions by using the seed-to-voxel strategy.

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

The Future of Freezing of Gait in Parkinson's: Exploring Potential Treatments and Preventive Strategies

By

More than half of patients diagnosed with Parkinson disease experience freezing of gait.

Immunotherapy Promising for Slowing Progression of ALS

Immunotherapy Promising for Slowing Progression of ALS

A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.

Academic Underachievement With Tourette, Tic Disorders

Academic Underachievement With Tourette, Tic Disorders

Individuals with Tourette syndrome or chronic tic disorders have lower likelihood of academic achievement.

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

Emerging Innovations in Parkinson Disease Treatment: Q&A With Dr Matthew Brodsky

By

Surgical interventions for Parkinson disease are experiencing a swell in innovation, thanks in part to the entry of two additional medical device companies into a field previously dominated by one company.

IBD Associated With Increased Risk of Parkinson Disease

IBD Associated With Increased Risk of Parkinson Disease

There is a significantly increased risk of Parkinson disease in patients with inflammatory bowel disease.

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

Inactivity, Obesity Exert No Significant Influence on Parkinson Disease Risk

By

Despite evidence suggesting there is an impact of physical activity and body mass index on the risk for Parkinson disease, a large prospective study published in Neurology shows that there is no significant association between prolonged sitting/inactivity or obesity with PD risk.

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

Traumatic Brain Injury Linked to Increased Parkinson Disease Risk in Veterans

By

Patients with TBI had a higher incidence of PD compared with patients without TBI.

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

Enhanced Scale Helps Accurately Identify Psychotic Symptoms in Parkinson Disease

By

Using information from these assessments, investigators identified participants as having either major psychotic symptoms, isolated minor psychotic symptoms, or no psychotic symptoms.

Lightning Can Affect Deep Brain Stimulation Devices

Lightning Can Affect Deep Brain Stimulation Devices

Lightning, which can result in strong electromagnetic fields, can interfere with deep brain stimulation devices.

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

By

Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

Factors Associated With Long-Term Psychotic Symptoms in Parkinson's

By

The assessment of psychiatric symptoms relied on only one question in the MDS-UPDRS, potentially leading to underestimation of these symptoms in this cohort.

IBD Associated With Increased Incidence of Parkinson Disease

IBD Associated With Increased Incidence of Parkinson Disease

Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Sign Up for Free e-newsletters



CME Focus