Multiple Sclerosis

Multiple Sclerosis, Systemic Lupus Linked by Genetic Variant

Multiple Sclerosis, Systemic Lupus Linked by Genetic Variant

A variant in TNFSF13B, encoding the cytokine and drug target B-cell activating factor (BAFF), was associated with both multiple sclerosis and SLE.

Exosomes in Relapsing-Remitting Multiple Sclerosis Have Distinct RNA Profile

Exosomes in Relapsing-Remitting Multiple Sclerosis Have Distinct RNA Profile

Fifteen different classes of transcripts detected 4 circulating exosomal sequences within the miRNA category that were differentially expressed.

Sodium Intake And Its Association With Multiple Sclerosis Progression

Sodium Intake And Its Association With Multiple Sclerosis Progression

Over a 5-year follow-up, there was no correlation between 24-hour urine sodium levels and conversion to clinically definite MS.

Pharmacist-Led Program May Improve MS Treatment Adherence

Pharmacist-Led Program May Improve MS Treatment Adherence

Communication with a pharmacist may help improve treatment adherence in multiple sclerosis.

In MS, Disease Duration, Lesion Load Predict Relapses and Disability Progression

In MS, Disease Duration, Lesion Load Predict Relapses and Disability Progression

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The post-hoc analysis sought to identify factors predictive of relapse and disability progression in people with MS enrolled in the TRANSFORMS study.

Ocrelizumab May Improve Cognitive Function in Relapsing Multiple Sclerosis

Ocrelizumab May Improve Cognitive Function in Relapsing Multiple Sclerosis

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Researchers sought to determine whether treatment with ocrelizumab improved measures of cognitive function better than interferon beta 1-a.

Teriflunomide for MS Associated With Low Rates of Infection, Lymphopenia

Teriflunomide for MS Associated With Low Rates of Infection, Lymphopenia

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Initial trials of teriflunomide have demonstrated low lymphocyte counts in patients with relapsing forms of MS.

In Multiple Sclerosis, Hand Strength May Indicate Disease Status

In Multiple Sclerosis, Hand Strength May Indicate Disease Status

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In patients with MS, hand function often correlates with measures of quality of life.

Multiple Sclerosis May Have Causal Link to Osteoporosis

Multiple Sclerosis May Have Causal Link to Osteoporosis

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The prevalence of osteoporosis was greater in patients with MS than in matched controls.

In MS, Anxiety, Cognitive Fatigue May Affect Visual Memory

In MS, Anxiety, Cognitive Fatigue May Affect Visual Memory

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Cognitive fatigue and anxiety are common symptoms reported by patients with multiple sclerosis.

Multiple Sclerosis Relapse Rate Linked to Puberty in Boys

Multiple Sclerosis Relapse Rate Linked to Puberty in Boys

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Boys with onset of MS during puberty experienced an increased rate of relapse compared with boys with MS onset before or after puberty.

Vitamin D Deficiency Affects Cognition in Multiple Sclerosis

Vitamin D Deficiency Affects Cognition in Multiple Sclerosis

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Longer studies are needed to further evaluate the effect of vitamin D supplementation on cognition in multiple sclerosis.

Pediatric Multiple Sclerosis Linked to Epstein-Barr, Herpes Simplex Virus Exposure

Pediatric Multiple Sclerosis Linked to Epstein-Barr, Herpes Simplex Virus Exposure

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Increased risk of pediatric multiple sclerosis was observed in patients with prior exposure to EBV, HSV-1, and vitamin D deficiency.

In Relapsing MS, Fatigue, Limb Problems May Signal Risk for Disease Conversion

In Relapsing MS, Fatigue, Limb Problems May Signal Risk for Disease Conversion

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In older patients with relapsing multiple sclerosis, patient-reported fatigue and problems with lower extremities may signal conversion to secondary progressive disease.

No Evidence of Disease Activity Achieved in Multiple Sclerosis with Dimethyl Fumarate

No Evidence of Disease Activity Achieved in Multiple Sclerosis with Dimethyl Fumarate

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More participants achieved clinical NEDA with DMF than placebo over 2 years in the integrated analysis.

Ocrelizumab Approved for Progressive, Relapsing Multiple Sclerosis

Ocrelizumab Approved for Progressive, Relapsing Multiple Sclerosis

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The biannual infusion is approved for the treatment of adults with relapsing and progressive forms of multiple sclerosis.

In Multiple Sclerosis, Anxiety May Signal Depression

In Multiple Sclerosis, Anxiety May Signal Depression

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A study aimed to clarify the relationship between anxiety and depression in patients with multiple sclerosis.

RENEW Trial: Promising Results for Optic Neuritis Treatment

RENEW Trial: Promising Results for Optic Neuritis Treatment

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Opicinumab may potentially enhance spontaneous remyelination after acute optic neuritis.

ICER Report: New Multiple Sclerosis Drugs More Effective, But Safety Concerns Abound

ICER Report: New Multiple Sclerosis Drugs More Effective, But Safety Concerns Abound

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Several new multiple sclerosis drugs, including natalizumab, may be more effective at reducing relapses but still come with serious safety concerns.

Relapsing-Remitting Multiple Sclerosis Halted With Immunosuppression, Stem Cell Transplant

Relapsing-Remitting Multiple Sclerosis Halted With Immunosuppression, Stem Cell Transplant

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Five years after treatment, nearly 70% of patients with relapsing-remitting multiple sclerosis showed no signs of disease progression.

MicroRNA in Multiple Sclerosis May Signify Disease Progression

MicroRNA in Multiple Sclerosis May Signify Disease Progression

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Several microRNA were found to be associated with lesion volume and brain atrophy in multiple sclerosis.

Risk-Benefit Analysis Helps Determine Multiple Sclerosis Therapy

Risk-Benefit Analysis Helps Determine Multiple Sclerosis Therapy

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Despite an elevated risk of PML, treatment with natalizumab results in slower disease progression than other treatments.

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

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Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

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Researchers report 2 cases of a severe B-cell-mediated CNS disease after treatment with alemtuzumab in patients with multiple sclerosis.

Template Improves Quality of Report on MRI for Multiple Sclerosis

Template Improves Quality of Report on MRI for Multiple Sclerosis

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More structured MRI reports may aid in the diagnosis of multiple sclerosis.

Potential Prognostic Biomarker for Clinically Isolated Syndrome

Potential Prognostic Biomarker for Clinically Isolated Syndrome

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It is not clear whether CSF CD27 could provide novel or simply complementary prognostic value in clinically isolated syndrome.

Low Neonatal Vitamin D May Increase Risk of MS

Low Neonatal Vitamin D May Increase Risk of MS

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Low levels of neonatal vitamin D may be linked with risk of developing multiple sclerosis.

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

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Previous MRI studies focused on gray matter changes only.

Alemtuzumab May Reduce Disability in Early MS

Alemtuzumab May Reduce Disability in Early MS

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The authors aimed to identify confirmed disability improvement (CDI), which reflects a clinically meaningful change in EDSS score.

Does Exercise Influence Risk of Multiple Sclerosis?

Does Exercise Influence Risk of Multiple Sclerosis?

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Researchers still recommend that patients with MS engage in physical activity for cardiovascular benefits.

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