Multiple Sclerosis

ICER Report: New Multiple Sclerosis Drugs More Effective, But Safety Concerns Abound

ICER Report: New Multiple Sclerosis Drugs More Effective, But Safety Concerns Abound

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Several new multiple sclerosis drugs, including natalizumab, may be more effective at reducing relapses but still come with serious safety concerns.

Relapsing-Remitting Multiple Sclerosis Halted With Immunosuppression, Stem Cell Transplant

Relapsing-Remitting Multiple Sclerosis Halted With Immunosuppression, Stem Cell Transplant

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Five years after treatment, nearly 70% of patients with relapsing-remitting multiple sclerosis showed no signs of disease progression.

MicroRNA in Multiple Sclerosis May Signify Disease Progression

MicroRNA in Multiple Sclerosis May Signify Disease Progression

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Several microRNA were found to be associated with lesion volume and brain atrophy in multiple sclerosis.

Risk-Benefit Analysis Helps Determine Multiple Sclerosis Therapy

Risk-Benefit Analysis Helps Determine Multiple Sclerosis Therapy

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Despite an elevated risk of PML, treatment with natalizumab results in slower disease progression than other treatments.

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

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Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

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Researchers report 2 cases of a severe B-cell-mediated CNS disease after treatment with alemtuzumab in patients with multiple sclerosis.

Template Improves Quality of Report on MRI for Multiple Sclerosis

Template Improves Quality of Report on MRI for Multiple Sclerosis

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More structured MRI reports may aid in the diagnosis of multiple sclerosis.

Potential Prognostic Biomarker for Clinically Isolated Syndrome

Potential Prognostic Biomarker for Clinically Isolated Syndrome

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It is not clear whether CSF CD27 could provide novel or simply complementary prognostic value in clinically isolated syndrome.

Low Neonatal Vitamin D May Increase Risk of MS

Low Neonatal Vitamin D May Increase Risk of MS

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Low levels of neonatal vitamin D may be linked with risk of developing multiple sclerosis.

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

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Previous MRI studies focused on gray matter changes only.

Alemtuzumab May Reduce Disability in Early MS

Alemtuzumab May Reduce Disability in Early MS

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The authors aimed to identify confirmed disability improvement (CDI), which reflects a clinically meaningful change in EDSS score.

Does Exercise Influence Risk of Multiple Sclerosis?

Does Exercise Influence Risk of Multiple Sclerosis?

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Researchers still recommend that patients with MS engage in physical activity for cardiovascular benefits.

Experimental Multiple Sclerosis Drug May Prevent Disease in Mice

Experimental Multiple Sclerosis Drug May Prevent Disease in Mice

Researchers believe that the drug may help prevent MS, since there was a 96% reduction in harmful clusters of B cells.

Psychiatric Disorders Common in Pediatric MS, Demyelinating Diseases

Psychiatric Disorders Common in Pediatric MS, Demyelinating Diseases

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Notably, patients who had documented psychotic and psychiatric disorders were more likely to be diagnosed with a demyelinating disease.

Dimethyl-Fumarate May Maintain NEDA After Natalizumab Discontinuation

Dimethyl-Fumarate May Maintain NEDA After Natalizumab Discontinuation

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Over 90% of participants achieved NEDA-3 after being transitioned to dimethyl-fumarate from natalizumab.

Smoking May Accelerate White Matter Damage in Progressive MS

Smoking May Accelerate White Matter Damage in Progressive MS

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The relationship between microstructural damage in NAWM and clinical measures was less clear, suggesting another mechanism.

Enriching Experiences May Protect Against Cognitive Decline in MS

Enriching Experiences May Protect Against Cognitive Decline in MS

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Researchers examined whether the cognitive reserve hypothesis could predict cognitive decline, gray matter volume changes, and white matter volume changes in MS patients.

High-Fat Diets May Increase Relapse Risk in Pediatric MS

High-Fat Diets May Increase Relapse Risk in Pediatric MS

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High-fat diets may increase the risk of relapse in children with MS, while high-vegetable diets may be protective.

Genetic Risk Score Identifies Pediatric Patients With Greater MS Relapse Risk

Genetic Risk Score Identifies Pediatric Patients With Greater MS Relapse Risk

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Six polymorphisms were found to be strongly associated with vitamin D levels in the patient population.

Axon Diameter May Help Detect, Track Multiple Sclerosis

Axon Diameter May Help Detect, Track Multiple Sclerosis

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Axon diameter dynamics may serve as a novel biomarker for MS disease course.

Early Tx Exposure May Prevent Progression in Pediatric Clinically Isolated Syndrome

Early Tx Exposure May Prevent Progression in Pediatric Clinically Isolated Syndrome

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Patients at the greatest risk of disability progression were older than 12 years, and had minimal exposure to DMTs.

BMI, Lipid Levels Influence Multiple Sclerosis Disease Course

BMI, Lipid Levels Influence Multiple Sclerosis Disease Course

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Higher BMI and lipid levels were associated with greater risk of relapse and disability progression.

Differentiating Multiple Sclerosis Mimics on MRI

Differentiating Multiple Sclerosis Mimics on MRI

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A proper MS diagnosis can only be made after obtaining imaging from the entire brain and understanding the clinical context.

Strategies to Curb Treatment Cost in Multiple Sclerosis

Strategies to Curb Treatment Cost in Multiple Sclerosis

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Several strategies for clinical practice and research may reduce the cost of MS treatment while maintaining efficacy.

Early Treatment and the Transition From Clinically Isolated Syndrome to MS

Early Treatment and the Transition From Clinically Isolated Syndrome to MS

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The findings from the extension study support prior research that showed the benefits of early treatment.

Routine MRI, Clinical Assessments Fail to Predict Prognosis in MS

Routine MRI, Clinical Assessments Fail to Predict Prognosis in MS

Routine evaluation with MRI appeared to have no clinical benefit over time.

Gut Bacteria and Its Emerging Role in Multiple Sclerosis

Gut Bacteria and Its Emerging Role in Multiple Sclerosis

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It has been proposed that the gut microbiome may be an important environmental risk factor in MS.

Successive Pregnancies Not Associated With MS Relapse Rate

Successive Pregnancies Not Associated With MS Relapse Rate

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Among study participants, relapse rate actually decreased from the first to second pregnancy.

Gut Bacteria Profile Differs in Patients with Multiple Sclerosis

Gut Bacteria Profile Differs in Patients with Multiple Sclerosis

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Differences in gut bacteria were apparent between patients with active RRMS and those in remission.

Pros and Cons: Vitamin D Supplementation in Multiple Sclerosis

Pros and Cons: Vitamin D Supplementation in Multiple Sclerosis

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While supplementation has produced a positive response in disease activity, adverse events based on dosing are concerning.

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