Magnesium Levels Linked to Dementia Risk

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Over a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia.
Over a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia.

HealthDay News — Magnesium levels, either too high or too low, are associated with an increased risk of dementia, according to a study publishe in Neurology.

Brenda CT Kieboom, MD, from the Erasmus MC-University Medical Center Rotterdam in the Netherlands, assessed serum magnesium levels in 9569 participants in the Rotterdam Study, who were free from dementia at baseline (1997-2008). Participants (mean age, 64.9 years; 56.6%women) were followed until January 1, 2015, to determine incident dementia.

The researchers found that over a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia

There was an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) (hazard ratios, 1.32 and 1.30, respectively).

"As we are the first to study this association, our results warrant replication in other population-based studies," the authors write.

Reference

Kieboom BCT, Licher S, Wolters FJ, et al. Serum magnesium is associated with the risk of dementia [published online September 20, 2017]. Neurology. doi:10.1212/WNL.0000000000004517

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