Neurodegenerative Diseases

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Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.

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Autoimmune Disease Hospitalization Linked to Future Dementia Risk

Autoimmune Disease Hospitalization Linked to Future Dementia Risk

Men with autoimmune diseases demonstrated a greater risk for dementia than women, especially women with multiple sclerosis.

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Mindfulness meditation was associated with improvements in measures of anxiety, depression, and negative thoughts.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Diagnosing Depression in Dementia: Available Tools

Diagnosing Depression in Dementia: Available Tools

As dementia worsens, caregivers often have to report symptoms on behalf of the patient, and they tend to report more depressive symptoms than patients do.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Can Too Much Sleep Increase Dementia Risk?

Can Too Much Sleep Increase Dementia Risk?

Researchers found that people who slept 9 or more hours per night were at an increased risk of dementia.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Albuminuria Linked to Cognitive Impairment, Dementia

Albuminuria Linked to Cognitive Impairment, Dementia

In a review, researchers found that elevated levels of albuminuria were linked to worse global cognitive performance and accelerated cognitive decline.

Dementia Combination Tx May Help Reduce Behavioral Symptoms in Alzheimer's

Dementia Combination Tx May Help Reduce Behavioral Symptoms in Alzheimer's

The combination treatment may have benefits, especially for patients who are unresponsive to donezepil alone.

Exposure to Traffic-Related Pollution May Increase Dementia Risk

Exposure to Traffic-Related Pollution May Increase Dementia Risk

The investigators believe the association is related to exposure to pollutants from cars and roads.

Dementia Drug May Elevate Risk for Pneumonia

Dementia Drug May Elevate Risk for Pneumonia

Memantine therapy may put users at greater risk of developing pneumonia.

Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

Alzheimer's Pathologies in Synucleinopathies Indicates Dementia Course

Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

Estradiol Hormone Therapy May Reduce Mortality in Vascular Dementia

Hormone therapy may reduce risk for death from vascular dementia in older women.

Beta-Blockers May Impact Quality of Life in Dementia Patients

Beta-Blockers May Impact Quality of Life in Dementia Patients

Patients experienced a 34% risk of a reduction in the ability to perform daily tasks independently.

Alzheimer's-Related Amyloid Found in the Heart

Alzheimer's-Related Amyloid Found in the Heart

Amyloid beta protein accumulation was present in the hearts of patients with Alzheimer's disease.

Treatment Guidance for Sleep Disorders in Dementia Lacking

Treatment Guidance for Sleep Disorders in Dementia Lacking

There is a clear lack of evidence in the pharmacologic guidance of sleep problems in dementia.

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Amyloid Deposits in Alzheimer's Also Affect Heart Health

Patients with Alzheimer's disease tended to have increased thickness in the wall of their left ventricle.

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

New Data: Causal Link Between Vitamin D, Alzheimer's Risk

The present findings, in combination with those from prior observational research, provide a solid rationale for further randomized trials.

No Benefit for Occupational Therapy in Alzheimer's Disease

No Benefit for Occupational Therapy in Alzheimer's Disease

There seems to be no effect on everyday functioning.

Solanezumab Fails Primary End Point in Alzheimer's Trial

Solanezumab Fails Primary End Point in Alzheimer's Trial

Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.

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