Neurodegenerative Diseases

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Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Beyond Solanezumab: Q&A With Ronald Petersen, MD, PhD

Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.

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Dementia Caregivers Are Often Women

Dementia Caregivers Are Often Women

Family members, especially women, provide most of the care for dementia patients.

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

Sleep behavior and irritability may be early noncognitive symptoms of Alzheimer's dementia.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

A history of 2 or more vascular risk factors assessed at baseline in the ARIC study was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

New Gene Linked to Accelerated Decline in Alzheimer's

New Gene Linked to Accelerated Decline in Alzheimer's

Participants with the Met allele lost memory and cognitive skills more rapidly than those without the gene mutation.

ALS Prognosis Better Predicted With Addition of MRI Measures

ALS Prognosis Better Predicted With Addition of MRI Measures

More accurate prediction of ALS prognosis can allow for better planned palliative care.

Alzheimer's Not Linked to a History of Psychiatric Disorders

Alzheimer's Not Linked to a History of Psychiatric Disorders

Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

Clinicians must keep this potentially increased risk in mind when prescribing long-term use of a specific anticholinergic drug to patients with DM suffering from OAB.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

Benzodiazepines increase risk for pneumonia-associated hospitalization, mortality in patients with Alzheimer disease.

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.

Off-Label Use of Antipsychotics in Veterans With PTSD, Dementia

Off-Label Use of Antipsychotics in Veterans With PTSD, Dementia

Veterans with comorbid PTSD and dementia were more likely to be prescribed second-generation antipsychotics.

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

Early onset of motor symptoms related to substance abuse appeared to significantly affect women compared with men.

Dementia Incidence Not Affected by Antioxidant Supplements

Dementia Incidence Not Affected by Antioxidant Supplements

After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.

Autoimmune Disease Hospitalization Linked to Future Dementia Risk

Autoimmune Disease Hospitalization Linked to Future Dementia Risk

Men with autoimmune diseases demonstrated a greater risk for dementia than women, especially women with multiple sclerosis.

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Mindfulness meditation was associated with improvements in measures of anxiety, depression, and negative thoughts.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Diagnosing Depression in Dementia: Available Tools

Diagnosing Depression in Dementia: Available Tools

As dementia worsens, caregivers often have to report symptoms on behalf of the patient, and they tend to report more depressive symptoms than patients do.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

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