Neurodegenerative Diseases

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MRI, CSF Biomarkers Predictive of Alzheimer's Dementia Risk

MRI, CSF Biomarkers Predictive of Alzheimer's Dementia Risk

The findings may be particularly useful at the individual level to determine personalized risk of progression to Alzheimer's dementia.

Alzheimer Disease Drug Candidate Granted Fast Track Status

Alzheimer Disease Drug Candidate Granted Fast Track Status

The FDA has granted Fast Track designation to ALZ-801 for the treatment of Alzheimer disease.

Alzheimer Disease Linked to High Cumulative Doses of Zolpidem in Elderly

Alzheimer Disease Linked to High Cumulative Doses of Zolpidem in Elderly

Zolpidem has been associated with memory loss and decline in cognitive function.

Late-Life Brain Volume Associated With Midlife Systemic Inflammation

Late-Life Brain Volume Associated With Midlife Systemic Inflammation

Systemic inflammation is associated with future neurodegeneration and cognitive aging in midlife.

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

Predicting Alzheimer Dementia Risk With CSF, MRI Clinical Biomarkers

There is an urgent need for individualized risk assessments for patients with mild cognitive impairment.

Examining Levels of Dependency in Older Adults

Examining Levels of Dependency in Older Adults

Researchers observed significant increases in the number of years participants lived with low levels of dependency.

Novel Alzheimer Drug Wins FDA Fast-Track Designation

Novel Alzheimer Drug Wins FDA Fast-Track Designation

The FDA has granted Fast Track status to an investigational agent for the treatment of Alzheimer disease.

Metformin Linked to Reduced Dementia Risk in Veterans With Type 2 Diabetes

Metformin Linked to Reduced Dementia Risk in Veterans With Type 2 Diabetes

Previous research has shown an association between some oral diabetes medications and lower incidence of dementia.

Tau Predicts Neurological Outcomes After Cardiac Arrest

Tau Predicts Neurological Outcomes After Cardiac Arrest

Serum tau is a promising novel biomarker for prediction of neurological outcome in patients with cardiac arrest.

Subjective Cognitive Decline Associated With Tauopathy and Global β-Amyloid Burden

Subjective Cognitive Decline Associated With Tauopathy and Global β-Amyloid Burden

Multiple biological factors may play a role when cognitive decline is observed in older health adults.

Mid-Life Hypertension in Women Linked to Dementia

Mid-Life Hypertension in Women Linked to Dementia

There was no correlation for early-adulthood hypertension with dementia, although among women these effect estimates were elevated.

Intepirdine Shows No Significant Benefit for Alzheimer Disease

Intepirdine Shows No Significant Benefit for Alzheimer Disease

Axovant Sciences announced that intepirdine did not meet its primary endpoints.

Global Tau Burden Linked to Cognitive Decline

Global Tau Burden Linked to Cognitive Decline

SCD is associated with increased entorhinal cortical tau burden and β-amyloid burden in healthy older adults.

Androgen Deprivation Therapy Does Not Increase Dementia or Alzheimer Risk

Androgen Deprivation Therapy Does Not Increase Dementia or Alzheimer Risk

Previous research has suggested an association between androgen deprivation therapy and risk for Alzheimer dementia.

Magnesium Levels Linked to Dementia Risk

Magnesium Levels Linked to Dementia Risk

Too high or too low magnesium levels are linked to an increased risk of dementia.

Alzheimer's Disease Risk Similar in Women and Men With APOE ε3/ε4 Genotype

Alzheimer's Disease Risk Similar in Women and Men With APOE ε3/ε4 Genotype

The APOE ε2/ε3 genotype was associated with a protective effect in women and decreased their AD risk to a greater degree than men.

Some Women Face Extended High-Risk Period of Developing Alzheimer's

Some Women Face Extended High-Risk Period of Developing Alzheimer's

Some female carriers of the APOE4 gene have a 10-year window where they are more likely to develop Alzheimer's than men.

Dementia Linked to Lithium in Drinking Water

Dementia Linked to Lithium in Drinking Water

The researchers observed a significant difference in lithium exposure for patients with a diagnosis of dementia vs controls.

Dementia Risk Increased in Elderly With Less REM Sleep

Dementia Risk Increased in Elderly With Less REM Sleep

Seniors may be more likely to develop dementia as they age if they spend less time in REM sleep.

Visual Impairment Linked to Cognitive Dysfunction in Seniors

Visual Impairment Linked to Cognitive Dysfunction in Seniors

Visual dysfunction is associated with poor cognitive function in older adults.

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