Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.
Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.
In a review, researchers found that elevated levels of albuminuria were linked to worse global cognitive performance and accelerated cognitive decline.
The combination treatment may have benefits, especially for patients who are unresponsive to donezepil alone.
The investigators believe the association is related to exposure to pollutants from cars and roads.
Memantine therapy may put users at greater risk of developing pneumonia.
Increasing severity of AD pathology inversely correlated to decreases in time from motor symptoms to dementia onset and death.
Hormone therapy may reduce risk for death from vascular dementia in older women.
Patients experienced a 34% risk of a reduction in the ability to perform daily tasks independently.
Amyloid beta protein accumulation was present in the hearts of patients with Alzheimer's disease.
There is a clear lack of evidence in the pharmacologic guidance of sleep problems in dementia.
Patients with Alzheimer's disease tended to have increased thickness in the wall of their left ventricle.
The present findings, in combination with those from prior observational research, provide a solid rationale for further randomized trials.
There seems to be no effect on everyday functioning.
Eli Lilly's investigational Alzheimer's drug failed to meet the primary end point in the phase 3 EXPEDITION3 trial.
Higher levels of education and better management of cardiovascular risk factors may have contributed to this improvement.
Signals sent to the hand emerge as a typed message on a tablet computer, according to the report.
Patients with mild cognitive impairment with preserved hippocampal volume are at increased risk for dementia with Lewy bodies vs Alzheimer disease.
The foods most negatively correlated with ALSFRS-R score were milk, lunchmeats, and beef and pork.
Future studies should investigate other neuropsychiatric factors for their impact on early signs of AD.
Women aged 75 and older with a history of hypertension, stroke, and periodontitis were at a significantly greater risk of dementia.
Neurology Advisor Articles
- Cannabis: Current Evidence and Research Recommendations
- Addressing Gender Differences in Concussion Diagnosis and Treatment
- Relapsing-Remitting Multiple Sclerosis Halted With Immunosuppression, Stem Cell Transplant
- Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring
- In Stroke, No Clear Benefit for Head Positioning