Neurodegenerative Diseases

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Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Advance Directives for Dementia: Honoring Patient Wishes When You Don't Know What They Are

Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.

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Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

Amyloid Positivity Increases Risk for Cognitive Impairment in Dementia-Free Patients

The findings from the study are limited in generalizability to the dementia-free patient population.

Risk of Dementia Up for Older Adults With Lowest Wealth

Risk of Dementia Up for Older Adults With Lowest Wealth

Researchers examined the correlation of education, wealth, and area-based deprivation with the incidence of dementia using data from the English Longitudinal Study of Ageing.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

These results suggest that antipsychotic exposure has no impact on relative mortality.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.

Study IDs Factors Linked to Quality of Life With Dementia

Study IDs Factors Linked to Quality of Life With Dementia

Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.

Depressive Symptoms Tied to Memory, Aging of the Brain

Depressive Symptoms Tied to Memory, Aging of the Brain

Greater depressive symptoms are associated with episodic memory and markers of brain aging in older Caribbean Hispanic patients.

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.

Approaches to Firearms for Persons With Dementia Discussed

Approaches to Firearms for Persons With Dementia Discussed

Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.

DRESS Prototype Promising for Persons With Dementia

DRESS Prototype Promising for Persons With Dementia

For persons with dementia, the DRESS prototype, can provide automated dressing support by identifying incorrect dressing scenarios.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically significant anxiety in midlife is associated with increased subsequent dementia risk over an interval of at least 10 years.

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

The combination of a rural upbringing and higher education levels may be protective against dementia and Alzheimer disease for African-Americans.

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

Individual patients with PCA and LDs demonstrated more right-lateralized patterns of atrophy and greater preservation of global cognition compared with patients with PCA without LDs.

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Use of anticholinergic drugs may be tied to a future diagnosis of dementia.

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

For nursing home residents with dementia and hip fracture, surgical hip fracture repair is associated with lower mortality.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

There is a linear correlation for physical activity with amyotrophic lateral sclerosis.

Controlling High Blood Pressure Could Prevent Dementia

Controlling High Blood Pressure Could Prevent Dementia

Controlling high blood pressure in older African-Americans may prevent future dementia.

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.

Sedentary Habits Tied to Medial Temporal Lobe Thinning

Sedentary Habits Tied to Medial Temporal Lobe Thinning

For non-demented middle-aged and older adults, there is an inverse correlation between medial temporal lobe thickness and sedentary behavior.

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.

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