Ronald Petersen, MD, PhD, discusses the implications of Eli Lilly's failed solanezumab trial on the future of Alzheimer's disease research.
Family members, especially women, provide most of the care for dementia patients.
Sleep behavior and irritability may be early noncognitive symptoms of Alzheimer's dementia.
Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.
A history of 2 or more vascular risk factors assessed at baseline in the ARIC study was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.
Participants with the Met allele lost memory and cognitive skills more rapidly than those without the gene mutation.
More accurate prediction of ALS prognosis can allow for better planned palliative care.
Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.
Clinicians must keep this potentially increased risk in mind when prescribing long-term use of a specific anticholinergic drug to patients with DM suffering from OAB.
The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.
Benzodiazepines increase risk for pneumonia-associated hospitalization, mortality in patients with Alzheimer disease.
No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.
Veterans with comorbid PTSD and dementia were more likely to be prescribed second-generation antipsychotics.
Early onset of motor symptoms related to substance abuse appeared to significantly affect women compared with men.
After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.
Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.
Men with autoimmune diseases demonstrated a greater risk for dementia than women, especially women with multiple sclerosis.
Mindfulness meditation was associated with improvements in measures of anxiety, depression, and negative thoughts.
Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.
As dementia worsens, caregivers often have to report symptoms on behalf of the patient, and they tend to report more depressive symptoms than patients do.
Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.
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