Neurodegenerative Diseases

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

Aerobic and Strength Exercise Doesn't Slow Cognitive Decline

An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.

Study IDs Factors Linked to Quality of Life With Dementia

Study IDs Factors Linked to Quality of Life With Dementia

Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

Treating Apathy in Alzheimer Disease Patients: A Meta-Analysis

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Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.

Approaches to Firearms for Persons With Dementia Discussed

Approaches to Firearms for Persons With Dementia Discussed

Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.

DRESS Prototype Promising for Persons With Dementia

DRESS Prototype Promising for Persons With Dementia

For persons with dementia, the DRESS prototype, can provide automated dressing support by identifying incorrect dressing scenarios.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically significant anxiety in midlife is associated with increased subsequent dementia risk over an interval of at least 10 years.

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

Rural Childhood, Higher Education Cuts Later Life Dementia Risk

The combination of a rural upbringing and higher education levels may be protective against dementia and Alzheimer disease for African-Americans.

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative Syndromes

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Individual patients with PCA and LDs demonstrated more right-lateralized patterns of atrophy and greater preservation of global cognition compared with patients with PCA without LDs.

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Certain Anticholinergic Drugs Appear to Raise Dementia Risk

Use of anticholinergic drugs may be tied to a future diagnosis of dementia.

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

Surgery for Hip Fx Cuts Mortality in NH Residents With Dementia

For nursing home residents with dementia and hip fracture, surgical hip fracture repair is associated with lower mortality.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

There is a linear correlation for physical activity with amyotrophic lateral sclerosis.

Controlling High Blood Pressure Could Prevent Dementia

Controlling High Blood Pressure Could Prevent Dementia

Controlling high blood pressure in older African-Americans may prevent future dementia.

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

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Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.

Sedentary Habits Tied to Medial Temporal Lobe Thinning

Sedentary Habits Tied to Medial Temporal Lobe Thinning

For non-demented middle-aged and older adults, there is an inverse correlation between medial temporal lobe thickness and sedentary behavior.

Sensory Cortex Hyperexcitability Predicts Shorter Survival in ALS

Sensory Cortex Hyperexcitability Predicts Shorter Survival in ALS

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Investigators assessed patients with sporadic ALS to determine the relationship between somatosensory cortex excitability and survival prognosis.

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

Melanoma, Nonmelanoma Skin Cancer Associated With Reduced Risk for Alzheimer's

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Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative Fateful Life Events Linked to Advanced Brain Aging

Negative fateful life events in midlife are associated with advanced predicted brain aging.

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

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Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

Genetic Risk Score Better Than APOE Alone for Assessing Risk for Alzheimer's Dementia

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The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.

Novel Therapy May Improve Symptoms in Early Huntington Disease

Novel Therapy May Improve Symptoms in Early Huntington Disease

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Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.

Blood Pressure-Dementia Link May Be Affected by Population Characteristics

Blood Pressure-Dementia Link May Be Affected by Population Characteristics

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Meta-analyses were conducted to assess the relationship between blood pressure and dementia in an aging population.

Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

Mood Stabilizer Use Among Long-Term Care Patients Declines Following CMS Program

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Investigators evaluated the association between initiation of the partnership and prescribing practices for antipsychotic and non-antipsychotic psychotropic medications.

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

Phase 3 Results Released for Investigational Alzheimer Disease Treatment

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Results showed that after 18-months, there was no significant statistical difference in cognitive or functional outcomes between those patients taking azeliragon and the placebo group.

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

High Amyloid Beta, Independent of Tau, Is Associated With Risk for Cognitive Decline

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Preclinical AD stages 1 and 2 demonstrated higher rates of linear cognitive decline with age, particularly with regard to story memory and processing speed measures.

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

Concern for Employer, Insurance Discrimination for Alzheimer's Patients

About half of adults surveyed expect a man with mild Alzheimer dementia to be discriminated against.

Impact of Mediterranean Diet on Aging Examined

Impact of Mediterranean Diet on Aging Examined

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Following a Mediterranean diet may be correlated with slowed aging.

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

Excessive Sleepiness Associated With Increased Aβ Accumulation in Elderly Without Dementia

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This study predominantly relied on a subjective patient reporting system to assess sleep disturbances, which may have limited the findings.

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

β-amyloidosis Alone is an Unreliable Predictor of Alzheimer Disease Progression

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Only 4 patients had progressed to clinical AD during the follow-up period, all of whom rated positive for amyloid β deposition.

Nurse Education Improves Post-Op Survival in Dementia Patients

Nurse Education Improves Post-Op Survival in Dementia Patients

Findings show lower post-surgical mortality among patients with Alzheimer's disease.

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