Individuals with Alzheimer disease have abnormalities and reductions in gene expression in the parahippocampal gyri that map to genes associated with the insulin receptor signaling pathway.
Approximately 5.5 million Americans have Alzheimer disease or dementia.
The results highlight the importance of evaluating and monitoring cognitive function in individuals with recent critical illness or major infections, especially if they are already at risk for dementia.
Preeclampsia seems to be associated with an increased risk for dementia, especially vascular dementia, with a stronger correlation for late-onset disease.
Neurological and neuropsychological examinations were performed to assess intellectual disabilities, and biological assays were performed on collected CSF and plasma.
Grand multiparity was associated with significantly worse Mini-Mental State Examination scores compared with those with 1 to 4 completed pregnancies.
Tiglutik is supplied as a thickened riluzole liquid that is intended to ease administration for patients with dysphagia.
In multivariable models, associations were observed between cardiovascular risk factors and cerebrovascular morphology, as well as white matter hyperintensity count.
Atrial fibrillation is associated with a faster global cognitive decline and an increased risk for dementia in older people.
In this cross-sectional study, the tau marker [18F]flortaucipir accurately distinguished Alzheimer's Disease dementia from other non-AD neurodegenerative disorders about 90% of the time.
Investigators evaluated cognition with measures reflecting executive function, episodic memory, semantic fluency, and processing speed on an annual basis.
There is a positive association between residential levels of air pollution and being diagnosed with dementia.
Age, sex and apolipoprotein E genotype can identify groups at high 10-year risk for Alzheimer disease and all dementia.
Multiple pathways account for the age-related increases in dementia risk.
The burden of Alzheimer disease and related dementias is expected to increase to 3.3% in the United States by 2060.
Based on the data, the FDA has concluded that the drug's benefit continues to outweigh its risks for patients with hallucinations and delusions associated with Parkinson's disease psychosis.
In this prospective cohort study, older patients with more optimal cardiovascular health metrics had a lower rate of developing dementia in a dose-dependent manner.
Retinal microvascular abnormalities are identified in cognitively healthy individuals who have biomarkers positive for Alzheimer disease.
Pseudobulbar affect is a significant national health issue in the United States, with approximately 2 million individuals affected.
Patients with a higher mean systolic blood pressure during follow-up had increased odds for brain infarcts compared with those with lower levels.
Having high insulin at baseline was associated with a greater risk for incident diabetes mellitus compared with low insulin values.
For older adults, increased numbers of optimal cardiovascular health metrics are associated with reduced risk of dementia.
Administering the Visual Association Test improves the predictive value of the Mini-Mental State Examination score for dementia.
Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.
Tau was found to be a significant predictor of mean diffusivity in the anterior temporal white matter.
There are currently no treatments available for frontotemporal dementia.
Positron emission tomographic imaging can directly measure synaptic loss with Alzheimer disease.
The findings suggest that confabulations by patients with AD are related to an impaired ability to mentally go back in time to retrieve the context in which the confabulated memories were encoded.
Lower cognitive ability total and verbal ability scores were predictive of greater risk for early-onset dementia.
Researchers from NeuroActiva, Inc. presented results of their randomized, double-blind, placebo-controlled phase 2A clinical trial of NA-831.
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