Neurodegenerative Diseases

Dementia Caregivers Are Often Women

Dementia Caregivers Are Often Women

Family members, especially women, provide most of the care for dementia patients.

New Amyotrophic Lateral Sclerosis Tx Approved by FDA

New Amyotrophic Lateral Sclerosis Tx Approved by FDA

Radicava is the first approved treatment for ALS in over 20 years.

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

Neuropsychiatric Symptoms May Be a Marker of Preclinical Alzheimer's

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Sleep behavior and irritability may be early noncognitive symptoms of Alzheimer's dementia.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

Alzheimer's Related Amyloid Deposits Linked to Vascular Risk Factors

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A history of 2 or more vascular risk factors assessed at baseline in the ARIC study was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

New Gene Linked to Accelerated Decline in Alzheimer's

New Gene Linked to Accelerated Decline in Alzheimer's

Participants with the Met allele lost memory and cognitive skills more rapidly than those without the gene mutation.

Stroke Prevention Strategies May Help Prevent Dementia

Stroke Prevention Strategies May Help Prevent Dementia

Findings from a new study suggest that engaging in stroke prevention strategies may help reduce the risk of dementia.

ALS Prognosis Better Predicted With Addition of MRI Measures

ALS Prognosis Better Predicted With Addition of MRI Measures

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More accurate prediction of ALS prognosis can allow for better planned palliative care.

Alzheimer's Not Linked to a History of Psychiatric Disorders

Alzheimer's Not Linked to a History of Psychiatric Disorders

Patients previously diagnosed with depression or anxiety did not have a greater risk of Alzheimer's.

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

Overactive Bladder Drugs Tied to Increased Dementia Risk in Diabetes

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Clinicians must keep this potentially increased risk in mind when prescribing long-term use of a specific anticholinergic drug to patients with DM suffering from OAB.

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

Intracranial Atherosclerotic Plaques May Signify Mild Cognitive Impairment, Dementia

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The association between intracranial atherosclerotic disease and dementia should be the focus of future studies.

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

Benzodiazepine Use In Alzheimer's: Weighing the Risks and Benefits

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Benzodiazepines increase risk for pneumonia-associated hospitalization, mortality in patients with Alzheimer disease.

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

β-Amyloid Accumulation Linked to Excessive Daytime Sleepiness

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Non-demented elderly patients experiencing excessive daytime sleepiness may be at increased risk for β-amyloid accumulation.

Alzheimer's Related Gene May Induce Psychosis in Females

Alzheimer's Related Gene May Induce Psychosis in Females

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Females with Alzheimer's disease, the APOE4 gene, and comorbid Lewy bodies were more likely to experience psychosis.

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

Alzheimer's Dementia Does Not Respond to IV Immunoglobulin

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No changes in imaging biomarkers including rates of edema or hemorrhage, or changes to whole brain volumes or hippocampal volumes were observed.

Off-Label Use of Antipsychotics in Veterans With PTSD, Dementia

Off-Label Use of Antipsychotics in Veterans With PTSD, Dementia

Veterans with comorbid PTSD and dementia were more likely to be prescribed second-generation antipsychotics.

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

Substance Abuse May Accelerate Onset of Motor Symptoms in Huntington's Disease

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Early onset of motor symptoms related to substance abuse appeared to significantly affect women compared with men.

Austedo Approved for Huntington's Chorea

Austedo Approved for Huntington's Chorea

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Deutetrabenazine is only the second drug approved for patients with Huntington's disease.

Dementia Incidence Not Affected by Antioxidant Supplements

Dementia Incidence Not Affected by Antioxidant Supplements

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After controlling for comorbidities and demographics, there was no significant difference in dementia incidence in the study groups.

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Proton Pump Inhibitor Use Increases Pneumonia Risk in Dementia

Independent risk factors for pneumonia included age, male gender, and underlying cerebrovascular disease.

Autoimmune Disease Hospitalization Linked to Future Dementia Risk

Autoimmune Disease Hospitalization Linked to Future Dementia Risk

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Men with autoimmune diseases demonstrated a greater risk for dementia than women, especially women with multiple sclerosis.

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

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Mindfulness meditation was associated with improvements in measures of anxiety, depression, and negative thoughts.

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Genetics Impact Donepezil Safety Profile in Mild Cognitive Impairment

Patients with the K-variant of the butyrylcholinesterase gene have an adverse reaction to treatment with donepezil.

Diagnosing Depression in Dementia: Available Tools

Diagnosing Depression in Dementia: Available Tools

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As dementia worsens, caregivers often have to report symptoms on behalf of the patient, and they tend to report more depressive symptoms than patients do.

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed Pathologies Common in Mild Cognitive Impairment

Mixed AD neuropathologic changes were more frequent than pure ADNC pathology among the group that remained MCI until death.

Can Too Much Sleep Increase Dementia Risk?

Can Too Much Sleep Increase Dementia Risk?

Researchers found that people who slept 9 or more hours per night were at an increased risk of dementia.

Dementia, Depression Common After Intracerebral Hemorrhage

Dementia, Depression Common After Intracerebral Hemorrhage

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Among ICH survivors, 63% developed both depression and dementia during a 5-year follow-up study.

Heart Failure, AFib May Precede Mild Alzheimer's Disease

Heart Failure, AFib May Precede Mild Alzheimer's Disease

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Early intervention in patients with heart failure or atrial fibrillation may help delay or prevent the onset of mild dementia.

Albuminuria Linked to Cognitive Impairment, Dementia

Albuminuria Linked to Cognitive Impairment, Dementia

In a review, researchers found that elevated levels of albuminuria were linked to worse global cognitive performance and accelerated cognitive decline.

Dementia Combination Tx May Help Reduce Behavioral Symptoms in Alzheimer's

Dementia Combination Tx May Help Reduce Behavioral Symptoms in Alzheimer's

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The combination treatment may have benefits, especially for patients who are unresponsive to donezepil alone.

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