The 400 mg solanezumab dose used in this study may not have been sufficient enough to provide clinically meaningful effects in these patients.
Investigators sought to examine factors that influence a cognitively normal individual's risk for developing symptoms of mild cognitive impairment due to Alzheimer disease.
Positive beliefs on age may protect against dementia.
The use of DBS in patients with Alzheimer disease is well tolerated and associated with less decline on the CDR-SB.
A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.
For older adults who are hospitalized after car crashes, vision testing and renewal requirements show to be related to reduced prevalence of dementia.
Solanezumab does not alter cognitive decline in patients with mild Alzheimer disease.
In older at-risk individuals, even APOE ε4 carriers, a multidomain lifestyle intervention seems to be beneficial.
Sugar found in caffeinated soda is associated with increased systemic inflammatory processes that may in turn be associated with neurodegeneration.
Zonisamide as an adjunct to levodopa therapy improves parkinsonism in patients with dementia with Lewy bodies.
Brain amyloidosis is associated with certain Alzheimer disease risk variants.
Because of dementia's prolonged disease course, advance care decisions and planning are often overlooked until it is too late.
For patients with mild-to-moderate Alzheimer disease, the use of idalopirdine does not improve cognition.
Guidelines: AAN Recommends Exercise, Cautious Prescribing for Patients With Mild Cognitive ImpairmentJanuary 15, 2018
A lower education level was associated with higher MCI prevalence in 8 of the class I studies.
Clinicians might benefit from standard guidelines on how to assess and refer patients with hearing loss.
There is an increased risk of dementia for patients with rheumatic diseases.
If confirmed in future studies, high triglycerides may present a modifiable risk factor for Alzheimer disease.
A hanful of studies reviewed the different types of interventions to prevent late-life dementia.
Anodal tDCS might not enhance short-term memory in healthy individuals when applied to the left DLPFC.
Increased amyloid-β production in adults can lead to disrupted sleep.
Interventions aimed at motor and cognitive impairments in Huntington disease may result in long-term functional improvement.
An increased risk for all-cause dementia is associated with low and high serum magnesium levels.
A population-based cohort study evaluated whether proton pump inhibitor use was associated with an increased risk for dementia.
Throughout the life course, higher body mass index and obesity are linked to cognitive decline, brain atrophy, reduced white matter and integrity of the blood-brain barrier, and elevated risk for late-onset Alzheimer disease.
It is predicted that by 2060, a total of 15 million American's will have clinical Alzheimer disease or mild cognitive impairment.
This analysis was comprised of well-educated and mostly white patients, so these findings may be difficult to generalize to all populations.
An approximately 1-SD increase in SBP correlated with lower scores for 2 tests that assessed for brain damage, dementia, and task switching.
The responsibility for discussing cessation of driving in patients with mild cognitive impairment or dementia often rests on the clinician, who may have little preparation for this difficult conversation.
Participants with MCI who developed Alzheimer disease at 3 years were more likely to demonstrate diminished theta increase on EEG compared with patients who did not develop the disease.
The findings suggest that [F-18]FDDNP-PET imaging can be used to diagnose chronic traumatic encephalopathy in at-risk patients.
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