Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.
An aerobic and strength exercise program does not slow cognitive impairment among people with mild-to-moderate dementia.
Good relationships, social engagement, and high-quality care are linked to better QoL for patients with dementia.
Methylphenidate demonstrated an improvement in apathy vs placebo when measured by the apathy evaluation scale, in addition, methylphenidate showed possible improvement in cognition.
Approaches to guns for patients with mild cognitive impairment could be similar to those for driving.
For persons with dementia, the DRESS prototype, can provide automated dressing support by identifying incorrect dressing scenarios.
Clinically significant anxiety in midlife is associated with increased subsequent dementia risk over an interval of at least 10 years.
The combination of a rural upbringing and higher education levels may be protective against dementia and Alzheimer disease for African-Americans.
Nonlanguage Mathematical, Visuospatial Learning Disabilities Likely in Focal Neurodegenerative SyndromesMay 10, 2018
Individual patients with PCA and LDs demonstrated more right-lateralized patterns of atrophy and greater preservation of global cognition compared with patients with PCA without LDs.
Use of anticholinergic drugs may be tied to a future diagnosis of dementia.
For nursing home residents with dementia and hip fracture, surgical hip fracture repair is associated with lower mortality.
There is a linear correlation for physical activity with amyotrophic lateral sclerosis.
Controlling high blood pressure in older African-Americans may prevent future dementia.
Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.
For non-demented middle-aged and older adults, there is an inverse correlation between medial temporal lobe thickness and sedentary behavior.
Investigators assessed patients with sporadic ALS to determine the relationship between somatosensory cortex excitability and survival prognosis.
Additional examination of these relationships is warranted to help clarify the complex biologic and psychosocial interactions among Alzheimer disease, malignant melanoma, and nonmelanoma skin cancer.
Negative fateful life events in midlife are associated with advanced predicted brain aging.
Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.
The genetic risk score primarily modified the risk for and onset of dementia and AD among homozygous carriers for APOE ε4.
Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.
Meta-analyses were conducted to assess the relationship between blood pressure and dementia in an aging population.
Investigators evaluated the association between initiation of the partnership and prescribing practices for antipsychotic and non-antipsychotic psychotropic medications.
Results showed that after 18-months, there was no significant statistical difference in cognitive or functional outcomes between those patients taking azeliragon and the placebo group.
Preclinical AD stages 1 and 2 demonstrated higher rates of linear cognitive decline with age, particularly with regard to story memory and processing speed measures.
About half of adults surveyed expect a man with mild Alzheimer dementia to be discriminated against.
Following a Mediterranean diet may be correlated with slowed aging.
This study predominantly relied on a subjective patient reporting system to assess sleep disturbances, which may have limited the findings.
Only 4 patients had progressed to clinical AD during the follow-up period, all of whom rated positive for amyloid β deposition.
Findings show lower post-surgical mortality among patients with Alzheimer's disease.
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