Stem Cell Transplant May Promote Remission in Myasthenia Gravis

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Stem Cell Transplant May Promote Remission in Myasthenia Gravis
Stem Cell Transplant May Promote Remission in Myasthenia Gravis

HealthDay News — Autologous hematopoietic stem cell transplant (HSCT) can result in durable, symptom-free, treatment-free remission of myasthenia gravis (MG), according to a study published in JAMA Neurology.

Adam Bryant, MD, from the University of Ottawa in Canada, and colleagues reported seven cases of severe MG treated with autologous HSCT in a retrospective study (6 for MG and 1 for follicular lymphoma with coincident active MG). Patients were followed for a median of 40 months.

The researchers found that 5 of the patients had immune dysregulation-related concurrent autoimmune or lymphoproliferative illnesses. Distinct clinical and electromyographic evidence of MG was seen in all of the patients. All patients achieved durable complete stable remission according to the Myasthenia Gravis Foundation of America clinical classification, with freedom from ongoing therapy and no residual symptoms. After autologous HSCT, 3 patients experienced transient viral reactivations and 1 developed a secondary autoimmune disease; all of these stabilized or resolved with treatment.

"Autologous HSCT results in long-term symptom- and treatment-free remission in patients with severe MG," the authors write. "The application of autologous HSCT for this and other autoimmune neurologic conditions warrants prospective study."

Reference

Bryant A, Atkins H, Pringle C, et al. Myasthenia Gravis Treated With Autologous Hematopoietic Stem Cell Transplantation. JAMA Neurol. 2016. doi:10.1001/jamaneurol.2016.0113.

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