Neuromuscular Disorders

Improved Balance in MS With Vestibular-Focused Rehab

Improved Balance in MS With Vestibular-Focused Rehab

A vestibular-related rehabilitation program is associated with imrpoved outcomes for patients with multiple sclerosis.

Examining the Relationship Between Vitamin D and Progressive Multiple Sclerosis

Examining the Relationship Between Vitamin D and Progressive Multiple Sclerosis

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Vitamin D deficiency is a risk factor for multiple sclerosis.

Multiple Sclerosis Disability, Fatigue Reduced With Caffeine Intake

Multiple Sclerosis Disability, Fatigue Reduced With Caffeine Intake

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The association suggests that caffeine consumption may play a protective role against multiple sclerosis-related disability.

Case Study: Improving Medication Adherence in MS Patients With Cognitive Deficits

Case Study: Improving Medication Adherence in MS Patients With Cognitive Deficits

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Poor medication timing, incorrect doses, medication disorganization, and under- or over-medication are some of the medication adherence issues that can occur in patients with MS and cognitive symptoms.

Quality of Life in Relapsing vs Progressive Multiple Sclerosis

Quality of Life in Relapsing vs Progressive Multiple Sclerosis

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Data obtained from the iConquerMS network highlight areas of quality of life that affect people with relapsing and progressive forms of MS and provide substantial basis for future research.

Screening for Comorbid Psychiatric Conditions in MS: Use of Validated Screening Tools

Screening for Comorbid Psychiatric Conditions in MS: Use of Validated Screening Tools

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Barriers to using screening tools included lack of time and lack of insurance compensation.

Motivating Patients With Multiple Sclerosis May Improve Treatment Adherence, Outcomes

Motivating Patients With Multiple Sclerosis May Improve Treatment Adherence, Outcomes

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Patients with multiple sclerosis who were motivated to remain adherent to treatment experienced overall better outcomes, including low relapse rates.

Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Disability Linked to Fatty Acid Intake

Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder Disability Linked to Fatty Acid Intake

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Intakes of fats and types of fatty acids may affect disability severity in multiple sclerosis and neuromyelitis optica spectrum disorder.

Relapsing-Remitting Multiple Sclerosis: Maintaining No Evidence of Disease Activity With Natalizumab

Relapsing-Remitting Multiple Sclerosis: Maintaining No Evidence of Disease Activity With Natalizumab

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Researchers aimed to determine the proportion of patients with early relapsing-remitting multiple sclerosis treated with natalizumab who achieve no evidence of disease activity at year 2.

Safety, Efficacy of Novel Oral Therapy for Relapsing MS

Safety, Efficacy of Novel Oral Therapy for Relapsing MS

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Ozanimod decreased both T2 and T1 brain lesions and brain volume loss in patients with relapsing multiple sclerosis.

Safety, Efficacy of Fingolimod vs IFN- β-1a in Adolescents With RRMS

Safety, Efficacy of Fingolimod vs IFN- β-1a in Adolescents With RRMS

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The randomized, double-blind PARADIGM study compared the safety and efficacy of fingolimod and interferon β-1a in teens with relapsing-remitting MS.

Small, Wearable Sensor Captures Progression, Limb Dysfunction in Multiple Sclerosis

Small, Wearable Sensor Captures Progression, Limb Dysfunction in Multiple Sclerosis

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Application of technology developed in the gaming and computer control industry offers the opportunity to create new metrics with greater sensitivity and reproducibility.

Rebound Relapse in MS Seen After Discontinuing Fingolimod

Rebound Relapse in MS Seen After Discontinuing Fingolimod

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Study authors emphasize the rebound relapse phenomenon as a potential complication in the safety of fingolimod.

Case: High-Dose Biotin Leading to Pseudohyperthyroidism in Multiple Sclerosis

Case: High-Dose Biotin Leading to Pseudohyperthyroidism in Multiple Sclerosis

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A 55-year-old woman with multiple sclerosis and no history of thyroid disease developed lab abnormalities suggestive of thyrotoxicosis on routine testing.

Interferon β-1a Delays 6-Month Confirmed Disability Progression in RRMS

Interferon β-1a Delays 6-Month Confirmed Disability Progression in RRMS

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The post-hoc analysis compared 6-month confirmed disability progression using patient data from PRISMS-2.

CRISP Trial Update: Suitability of Antipsychotic Medications for MS

CRISP Trial Update: Suitability of Antipsychotic Medications for MS

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CRISP will determine the suitability of clozapine and risperidone as a treatment for progressive multiple sclerosis.

Exploring New Treatments for MS: Safety, Efficacy of Intravenous Cladribine

Exploring New Treatments for MS: Safety, Efficacy of Intravenous Cladribine

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Researchers examined patients' disease course and the number of clinical attacks to determine the safety and efficacy of intravenous cladribine.

Low Vitamin D in Obesity Not Associated With Risk for Multiple Sclerosis

Low Vitamin D in Obesity Not Associated With Risk for Multiple Sclerosis

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Obesity-associated lowering of vitamin D levels may not mediate the putative causal relationship between obesity and multiple sclerosis.

Multiple Sclerosis Development in Two Teens After HPV Vaccination

Multiple Sclerosis Development in Two Teens After HPV Vaccination

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Authors describe 2 case reports of MS in the pediatric population after administration of HPV vaccination.

Annualized Relapse Rates Compared Among 3 RRMS Therapies

Annualized Relapse Rates Compared Among 3 RRMS Therapies

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The EFFECT study compared the efficacy of dimethyl fumarate vs other disease-modifying therapies, including fingolimod and glatiramer acetate in patients with relapsing-remitting multiple sclerosis.

Stable Disability in Progressive Multiple Sclerosis With Teriflunomide

Stable Disability in Progressive Multiple Sclerosis With Teriflunomide

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A significant unmet need remains for an effective, well-tolerated, and convenient treatment for patients with progressive forms of MS.

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

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The measurement may provide a dynamic measure of axonal damage in a disease in which neuropathy is the only neurologic manifestation.

Rituximab associated with lower drug discontinuation and disease relapse rates in multiple sclerosis

Rituximab was associated with lower discontinuation rates as compared to other disease-modifying treatments in newly diagnosed patients with relapsing-remitting multiple sclerosis.

Predicting MS in Patients With Clinically Isolated Syndrome: MAGNIMS vs McDonald Criteria

Predicting MS in Patients With Clinically Isolated Syndrome: MAGNIMS vs McDonald Criteria

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Researchers sought to compare 2010 McDonald and MAGNIMS criteria for predicting conversion to MS from clinically isolated syndrome.

Increased Disability, Grey Matter Loss in MS Linked to Anti-Müllerian Hormone Levels

Increased Disability, Grey Matter Loss in MS Linked to Anti-Müllerian Hormone Levels

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Greater disability was associated with lower anti-Müllerian hormone levels in women with MS.

Online Keyboard Tapping Assessment Accurately Evaluates MS Disease Severity

Online Keyboard Tapping Assessment Accurately Evaluates MS Disease Severity

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The BRAIN test is limited by its ability to only assess upper limb function.

Predicting ALS Disease Progression With Respiratory Function Decline

Predicting ALS Disease Progression With Respiratory Function Decline

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Patients older than 65 were more likely to have steeper declines in slow vital capacity.

Oral, IV Methylprednisolone Show Similar Benefits for Multiple Sclerosis Relapse

Oral, IV Methylprednisolone Show Similar Benefits for Multiple Sclerosis Relapse

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While both intravenous and oral administrations of methylprednisolone showed similar efficacy, the investigators noted that oral administration may be more tolerable and cost-effective.

Improved Outcomes in Duchenne Muscular Dystrophy With Long-Term Glucocorticoid Treatment

Improved Outcomes in Duchenne Muscular Dystrophy With Long-Term Glucocorticoid Treatment

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Patients who received deflazacort were older when they reached disease milestones compared with patients taking prednisolone or prednisone.

Fatty Liver Disease Common in Spinal-Bulbar Muscular Atrophy

Fatty Liver Disease Common in Spinal-Bulbar Muscular Atrophy

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Because of the liver's prominent role in drug metabolism, clinicians should monitor patients' hepatic function.

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