Neuromuscular Disorders

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

Case Report: Treatment With Alemtuzumab May Prompt Severe CNS Disease

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Researchers report 2 cases of a severe B-cell-mediated CNS disease after treatment with alemtuzumab in patients with multiple sclerosis.

Alexion Seeking New Indication for Myasthenia Gravis Drug

Alexion Seeking New Indication for Myasthenia Gravis Drug

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Soliris is currently approved to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).

Template Improves Quality of Report on MRI for Multiple Sclerosis

Template Improves Quality of Report on MRI for Multiple Sclerosis

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More structured MRI reports may aid in the diagnosis of multiple sclerosis.

Potential Prognostic Biomarker for Clinically Isolated Syndrome

Potential Prognostic Biomarker for Clinically Isolated Syndrome

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It is not clear whether CSF CD27 could provide novel or simply complementary prognostic value in clinically isolated syndrome.

FDA Approves First Treatment for Spinal Muscular Atrophy

FDA Approves First Treatment for Spinal Muscular Atrophy

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The US FDA has approved the first drug for the treatment of spinal muscular atrophy, a genetic disease that often results in premature death.

ACE Inhibitors May Help Slow Myocardial Fibrosis In Muscular Dystrophy

ACE Inhibitors May Help Slow Myocardial Fibrosis In Muscular Dystrophy

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Patients who received ACE inhibitors showed a slower progression of myocardial fibrosis and fewer cardiovascular events.

Low Neonatal Vitamin D May Increase Risk of MS

Low Neonatal Vitamin D May Increase Risk of MS

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Low levels of neonatal vitamin D may be linked with risk of developing multiple sclerosis.

New Drug for Spinal Muscular Atrophy Shows Promise

New Drug for Spinal Muscular Atrophy Shows Promise

Despite the benefits observed, the improvements still do not represent normal muscle function.

Surgery May Boost Risk of Guillain-Barré in Immuno-Compromised

Surgery May Boost Risk of Guillain-Barré in Immuno-Compromised

Patients with cancer or an autoimmune disease who underwent surgery were at a greater risk.

Rituximab Offers Hope for Refractory Myasthenia Gravis

Rituximab Offers Hope for Refractory Myasthenia Gravis

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Sixty-three percent of patients achieved a complete and stable response that allowed them to discontinue all immunotherapies.

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

Gray Matter, White Matter Ratio Predicts Multiple Sclerosis Progression

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Previous MRI studies focused on gray matter changes only.

A Good Diet Translates into Better Functionality in ALS

A Good Diet Translates into Better Functionality in ALS

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The foods most negatively correlated with ALSFRS-R score were milk, lunchmeats, and beef and pork.

Alemtuzumab May Reduce Disability in Early MS

Alemtuzumab May Reduce Disability in Early MS

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The authors aimed to identify confirmed disability improvement (CDI), which reflects a clinically meaningful change in EDSS score.

Does Exercise Influence Risk of Multiple Sclerosis?

Does Exercise Influence Risk of Multiple Sclerosis?

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Researchers still recommend that patients with MS engage in physical activity for cardiovascular benefits.

Experimental Multiple Sclerosis Drug May Prevent Disease in Mice

Experimental Multiple Sclerosis Drug May Prevent Disease in Mice

Researchers believe that the drug may help prevent MS, since there was a 96% reduction in harmful clusters of B cells.

Eteplirsen Earns Accelerated Approval for Duchenne Muscular Dystrophy

Eteplirsen Earns Accelerated Approval for Duchenne Muscular Dystrophy

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Eteplirsen is the first drug approved in the US for the treatment of DMD.

Psychiatric Disorders Common in Pediatric MS, Demyelinating Diseases

Psychiatric Disorders Common in Pediatric MS, Demyelinating Diseases

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Notably, patients who had documented psychotic and psychiatric disorders were more likely to be diagnosed with a demyelinating disease.

Dimethyl-Fumarate May Maintain NEDA After Natalizumab Discontinuation

Dimethyl-Fumarate May Maintain NEDA After Natalizumab Discontinuation

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Over 90% of participants achieved NEDA-3 after being transitioned to dimethyl-fumarate from natalizumab.

Smoking May Accelerate White Matter Damage in Progressive MS

Smoking May Accelerate White Matter Damage in Progressive MS

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The relationship between microstructural damage in NAWM and clinical measures was less clear, suggesting another mechanism.

Enriching Experiences May Protect Against Cognitive Decline in MS

Enriching Experiences May Protect Against Cognitive Decline in MS

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Researchers examined whether the cognitive reserve hypothesis could predict cognitive decline, gray matter volume changes, and white matter volume changes in MS patients.

High-Fat Diets May Increase Relapse Risk in Pediatric MS

High-Fat Diets May Increase Relapse Risk in Pediatric MS

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High-fat diets may increase the risk of relapse in children with MS, while high-vegetable diets may be protective.

Genetic Risk Score Identifies Pediatric Patients With Greater MS Relapse Risk

Genetic Risk Score Identifies Pediatric Patients With Greater MS Relapse Risk

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Six polymorphisms were found to be strongly associated with vitamin D levels in the patient population.

Axon Diameter May Help Detect, Track Multiple Sclerosis

Axon Diameter May Help Detect, Track Multiple Sclerosis

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Axon diameter dynamics may serve as a novel biomarker for MS disease course.

Early Tx Exposure May Prevent Progression in Pediatric Clinically Isolated Syndrome

Early Tx Exposure May Prevent Progression in Pediatric Clinically Isolated Syndrome

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Patients at the greatest risk of disability progression were older than 12 years, and had minimal exposure to DMTs.

BMI, Lipid Levels Influence Multiple Sclerosis Disease Course

BMI, Lipid Levels Influence Multiple Sclerosis Disease Course

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Higher BMI and lipid levels were associated with greater risk of relapse and disability progression.

Corticosteroids May Inhibit Recovery in Facial Palsy

Corticosteroids May Inhibit Recovery in Facial Palsy

Those who received antibiotic monotherapy had better outcomes.

Differentiating Multiple Sclerosis Mimics on MRI

Differentiating Multiple Sclerosis Mimics on MRI

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A proper MS diagnosis can only be made after obtaining imaging from the entire brain and understanding the clinical context.

Strategies to Curb Treatment Cost in Multiple Sclerosis

Strategies to Curb Treatment Cost in Multiple Sclerosis

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Several strategies for clinical practice and research may reduce the cost of MS treatment while maintaining efficacy.

Deflazacort Improves Muscle Strength, Functional Outcomes in Duchenne Muscular Dystrophy

Deflazacort Improves Muscle Strength, Functional Outcomes in Duchenne Muscular Dystrophy

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Over 52 weeks, patients taking deflazacort experienced improved muscle strength and less weight gain compared with prednisone.

Thymectomy Helps Improve Strength in Myasthenia Gravis

Thymectomy Helps Improve Strength in Myasthenia Gravis

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Patients who underwent surgery also experienced lower distress levels from treatment-related symptoms.

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