Researchers report 2 cases of a severe B-cell-mediated CNS disease after treatment with alemtuzumab in patients with multiple sclerosis.
Soliris is currently approved to treat paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
More structured MRI reports may aid in the diagnosis of multiple sclerosis.
It is not clear whether CSF CD27 could provide novel or simply complementary prognostic value in clinically isolated syndrome.
The US FDA has approved the first drug for the treatment of spinal muscular atrophy, a genetic disease that often results in premature death.
Patients who received ACE inhibitors showed a slower progression of myocardial fibrosis and fewer cardiovascular events.
Low levels of neonatal vitamin D may be linked with risk of developing multiple sclerosis.
Despite the benefits observed, the improvements still do not represent normal muscle function.
Patients with cancer or an autoimmune disease who underwent surgery were at a greater risk.
Sixty-three percent of patients achieved a complete and stable response that allowed them to discontinue all immunotherapies.
Previous MRI studies focused on gray matter changes only.
The foods most negatively correlated with ALSFRS-R score were milk, lunchmeats, and beef and pork.
The authors aimed to identify confirmed disability improvement (CDI), which reflects a clinically meaningful change in EDSS score.
Researchers still recommend that patients with MS engage in physical activity for cardiovascular benefits.
Researchers believe that the drug may help prevent MS, since there was a 96% reduction in harmful clusters of B cells.
Eteplirsen is the first drug approved in the US for the treatment of DMD.
Notably, patients who had documented psychotic and psychiatric disorders were more likely to be diagnosed with a demyelinating disease.
Over 90% of participants achieved NEDA-3 after being transitioned to dimethyl-fumarate from natalizumab.
The relationship between microstructural damage in NAWM and clinical measures was less clear, suggesting another mechanism.
Researchers examined whether the cognitive reserve hypothesis could predict cognitive decline, gray matter volume changes, and white matter volume changes in MS patients.
High-fat diets may increase the risk of relapse in children with MS, while high-vegetable diets may be protective.
Six polymorphisms were found to be strongly associated with vitamin D levels in the patient population.
Axon diameter dynamics may serve as a novel biomarker for MS disease course.
Patients at the greatest risk of disability progression were older than 12 years, and had minimal exposure to DMTs.
Higher BMI and lipid levels were associated with greater risk of relapse and disability progression.
Those who received antibiotic monotherapy had better outcomes.
A proper MS diagnosis can only be made after obtaining imaging from the entire brain and understanding the clinical context.
Several strategies for clinical practice and research may reduce the cost of MS treatment while maintaining efficacy.
Over 52 weeks, patients taking deflazacort experienced improved muscle strength and less weight gain compared with prednisone.
Patients who underwent surgery also experienced lower distress levels from treatment-related symptoms.
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