Neuromuscular Disorders

Eculizumab Safe, Tolerable for Refractory Generalized Myasthenia Gravis

Eculizumab Safe, Tolerable for Refractory Generalized Myasthenia Gravis

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Treatment with eculizumab was associated with a significant benefit on quality of life.

Risk for Guillain-Barré Syndrome Associated With Early Life Immune-Mediated Disorders

Risk for Guillain-Barré Syndrome Associated With Early Life Immune-Mediated Disorders

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Rheumatological disorders were associated with a 7-fold risk of developing Guillain-Barré syndrome.

Nusinersen Improves Motor Function, Survival in Infants With Spinal Muscular Atrophy

Nusinersen Improves Motor Function, Survival in Infants With Spinal Muscular Atrophy

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Patients who received nusinersen had a greater likelihood of survival compared to those who received sham treatment.

Neuropsychiatric Conditions Common in Relatives of Patients With Amyotrophic Lateral Sclerosis

Neuropsychiatric Conditions Common in Relatives of Patients With Amyotrophic Lateral Sclerosis

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Repeat expansion of the C9orf72 gene does not account for the elevated prevalence of neuropsychiatric disease in relatives of patients with amyotrophic lateral sclerosis.

Visualizing Peripheral Nerve Involvement in MS With Magnetic Resonance Neurography

Visualizing Peripheral Nerve Involvement in MS With Magnetic Resonance Neurography

Peripheral nerve involvement can be visualized and quantified by high-resolution MRN in MS patients.

Risk of Multiple Sclerosis Associated With Epstein-Barr, Cytomegalovirus Infection

Risk of Multiple Sclerosis Associated With Epstein-Barr, Cytomegalovirus Infection

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Investigators strived to determine the association between multiple sclerosis and Epstein-Barr virus or cytomegalovirus infection in blacks and Hispanics.

Drug May Slow Conversion to Definite MS From Clinically Isolated Syndrome

Drug May Slow Conversion to Definite MS From Clinically Isolated Syndrome

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Aubagio may cause delays in conversion to clinical definite MS by slowing the loss of cortical grey matter.

Switch to Alemtuzumab Reduces MS Disease Activity

Switch to Alemtuzumab Reduces MS Disease Activity

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Patients experienced reduced disease activity when switched to alemtuzumab.

Dimethyl Fumarate as Exit Strategy From Natalizumab Treatment in Multiple Sclerosis

Dimethyl Fumarate as Exit Strategy From Natalizumab Treatment in Multiple Sclerosis

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Patients with relapsing-remittingmultiple sclerosis with high titers of JCV antibodies and who were being treated with natalizumab for more than 2 years were enrolled in the study.

Novel Multiple Sclerosis Drug Shows Promise

Novel Multiple Sclerosis Drug Shows Promise

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Celgene announced new Phase 3 data evaluating the safety and efficacy of ozanimod vs Avonex for RMS.

Disability Progression Slowed in Relapsing MS With Ocrelizumab Treatment

Disability Progression Slowed in Relapsing MS With Ocrelizumab Treatment

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Data show superiority of OCREVUS compared to Rebif in reducing disability progression independent of relapse activity in people with RMS.

Fingolimod Promising for Pediatric Relapsing Multiple Sclerosis

Fingolimod Promising for Pediatric Relapsing Multiple Sclerosis

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There are no FDA-approved MS therapies for the pediatric population.

Comorbidities in Multiple Sclerosis Associated With Diagnostic Delays, Mortality Risk

Comorbidities in Multiple Sclerosis Associated With Diagnostic Delays, Mortality Risk

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As early treatment of multiple sclerosis is crucial, it is important to identify the factors that may delay diagnosis.

Comorbidities May Increase Relapse Risk in Multiple Sclerosis

Comorbidities May Increase Relapse Risk in Multiple Sclerosis

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An emerging line of inquiry suggests a potential association between comorbidities and MS relapses, but studies have been limited.

OSA Screening Advised for Fatigued Patients With MS

OSA Screening Advised for Fatigued Patients With MS

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Patients with multiple sclerosis who experience severe fatigue should be screened for obstructive sleep apnea.

Multiple Sclerosis Lesion Location Linked to Hyperalgesia, Hypoalgesia

Multiple Sclerosis Lesion Location Linked to Hyperalgesia, Hypoalgesia

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In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex may be associated with hypoalgesia, and lesions in the posterior periventricular area, with hyperalgesia.

Earlier Onset of Multiple Sclerosis Linked to Cesarean Delivery, Artificial Lactation

Earlier Onset of Multiple Sclerosis Linked to Cesarean Delivery, Artificial Lactation

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Researchers believe that environmental factors may impact disease severity characteristics in genetically susceptible populations.

Detecting Cognitive Decline in Multiple Sclerosis With Shortened BICAMS

Detecting Cognitive Decline in Multiple Sclerosis With Shortened BICAMS

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With its 20-minute application time, the BICAMS is one of the few tools available for small centers with only a few staff members who might not be trained in administering neuropsychological tests.

Vitamin D Levels in Multiple Sclerosis Impact Epstein-Barr Viral Load

Vitamin D Levels in Multiple Sclerosis Impact Epstein-Barr Viral Load

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Viral load of Epstien-Barr virus and human herpesvirus 6 may be higher in patients with MS who also have low vitamin D levels.

Relapsing-Remitting Multiple Sclerosis Benefits From Early Treatment With Cladribine

Relapsing-Remitting Multiple Sclerosis Benefits From Early Treatment With Cladribine

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Early treatment with cladribine in MS may help keep patients relapse-free with little to no progression in disability.

Plasma Exchange Should Be Used With Caution in Progressive Multifocal Leukoencephalopathy

Plasma Exchange Should Be Used With Caution in Progressive Multifocal Leukoencephalopathy

Plasma exchange and steroids should be used with caution in patients with PML.

Risk for PML in Multiple Sclerosis Predicted With Anti-JCV Antibody Index

Risk for PML in Multiple Sclerosis Predicted With Anti-JCV Antibody Index

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Improving PML risk estimates is an important component of treatment with natalizumab for multiple sclerosis.

FDA Approves Myasthenia Gravis Treatment

FDA Approves Myasthenia Gravis Treatment

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The FDA has approved Soliris for treating adults with myasthenia gravis.

Brain Inflammation Associated With Depression, Anxiety in Multiple Sclerosis

Brain Inflammation Associated With Depression, Anxiety in Multiple Sclerosis

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Central inflammatory mediators may be responsible for mood-related symptoms in patients with multiple sclerosis.

Pediatric Multiple Sclerosis Relapse Associated With Fat Intake

Pediatric Multiple Sclerosis Relapse Associated With Fat Intake

Increased fat intake is associated with a higher risk of relapse for children with multiple sclerosis.

Fatigue in Multiple Sclerosis Reduced With TDCS

Fatigue in Multiple Sclerosis Reduced With TDCS

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In patients who underwent tDCS, there were significant reductions in fatigue associated with multiple sclerosis.

Amyotrophic Lateral Sclerosis Progression Associated With Changes in Immune Status

Amyotrophic Lateral Sclerosis Progression Associated With Changes in Immune Status

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The findings suggest that changes in immune status may be a consequence of ALS.

ALS Risk Reduced With Exposure to Exogenous Hormones

ALS Risk Reduced With Exposure to Exogenous Hormones

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Results suggest that sex hormones may play a role in the development of amyotrophic lateral sclerosis.

New Doses of Generic Copaxone Approved

New Doses of Generic Copaxone Approved

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The mechanism by which glatiramer acetate exerts its therapeutic effect in MS is unknown, however it is thought to act by modifying immune processes.

Ask the Expert: Managing Urinary Retention in Multiple Sclerosis

Ask the Expert: Managing Urinary Retention in Multiple Sclerosis

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John Stoffel, MD, Professor of Urology, Service Chief, and Associate Chair for Ambulatory Urology in the University of Michigan Department of Urology discusses the management of urinary retention in patients with MS.

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