Neuromuscular Disorders

Presence of CHI3L1 and NFL in CSF Predicts Risk for Demyelinating Syndromes

Presence of CHI3L1 and NFL in CSF Predicts Risk for Demyelinating Syndromes

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Investigators assess the diagnostic value of 2 CSF biomarkers to distinguish pediatric acquired demyelinating syndromes from non-acquired demyelinating syndromes.

OCD in Duchenne Muscular Dystrophy Features Distinct Phenotype, Associated Symptoms

OCD in Duchenne Muscular Dystrophy Features Distinct Phenotype, Associated Symptoms

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Investigators aim to facilitate early recognition and consideration for patients with Duchenne muscular dystrophy and internalizing psychiatric symptoms.

FDA Accepts NDA Resubmission for Oral Cladribine in Relapsing MS

FDA Accepts NDA Resubmission for Oral Cladribine in Relapsing MS

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The NDA resubmission is in response to the FDA's Complete Response Letter issued in 2011 which requested an improved understanding of the safety risks and overall benefit-risk profile.

Organic Solvents Plus Genetics May Increase Risk of Multiple Sclerosis

Organic Solvents Plus Genetics May Increase Risk of Multiple Sclerosis

The combination of genetics and exposure to organic solvents in paints and varnishes increases the risk of multiple sclerosis.

Understanding ICU-Acquired Neuromuscular Dysfunction: Triggers, Risk Factors, and Treatments

Understanding ICU-Acquired Neuromuscular Dysfunction: Triggers, Risk Factors, and Treatments

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ICU-acquired weakness syndromes manifest themselves in a range of ways among patients — as a spectrum of disease rather than in specific form.

FDA Lifts Clinical Hold on Trial for Duchenne Muscular Dystrophy Treatment

FDA Lifts Clinical Hold on Trial for Duchenne Muscular Dystrophy Treatment

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SGT-001 is a novel adeno-associated viral vector mediated gene transfer that could potentially address the underlying genetic cause of DMD, mutations in the dystrophin gene.

Reduced Disability Progression, Adverse Events Top Considerations When Selecting Multiple Sclerosis Therapy

Reduced Disability Progression, Adverse Events Top Considerations When Selecting Multiple Sclerosis Therapy

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A majority of the respondents in both groups identified reduced disability progression as a priority.

Immunotherapy Promising for Slowing Progression of ALS

Immunotherapy Promising for Slowing Progression of ALS

A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.

Association Between Vitamin D Supplementation, Multiple Sclerosis Relapse Still Unclear

Association Between Vitamin D Supplementation, Multiple Sclerosis Relapse Still Unclear

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Although the study demonstrated a lower relapse rate among patients with MS who supplemented their diet with vitamin D, the analysis did not reach statistical significance.

Various Clinical Disturbances Precede MS Diagnosis

Various Clinical Disturbances Precede MS Diagnosis

Various clinical symptoms precede the diagnosis of multiple sclerosis by several years.

Eculizumab May Improve Independent Walking Ability in Guillain-Barré Syndrome

Eculizumab May Improve Independent Walking Ability in Guillain-Barré Syndrome

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High-dose intravenous immunoglobulin therapy was administered to all patients and may have contributed to neutralization of eculizumab.

FDA Approves First Multiple Sclerosis Treatment for Pediatric Patients

FDA Approves First Multiple Sclerosis Treatment for Pediatric Patients

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The FDA's decision was based on data from the Phase 3 PARADIGMS study (N=215) which evaluated the safety and efficacy of oral fingolimod vs interferon beta-1a injection in pediatric patients aged 10 to <18 years with relapsing MS.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

There is a linear correlation for physical activity with amyotrophic lateral sclerosis.

Online Fatigue Management Feasible, Effective for Multiple Sclerosis

Online Fatigue Management Feasible, Effective for Multiple Sclerosis

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Investigators designed a parallel-group, 2-arm, randomized controlled trial to evaluate ELEVIDA, an online fatigue management program based on cognitive behavioral therapy and other therapy-based strategies.

Facioscapulohumeral Muscular Dystrophy Treatment Gets Fast Track Status

Facioscapulohumeral Muscular Dystrophy Treatment Gets Fast Track Status

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ACE-083 is currently being studied in a Phase 2 trial for FSHD and another for Charcot-Marie-Tooth (CMT) disease.

Dimethyl Fumarate May Be Safe, Effective for Pediatric Multiple Sclerosis

Dimethyl Fumarate May Be Safe, Effective for Pediatric Multiple Sclerosis

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Previous studies have shown that delayed-release DMF is safe and effective in treating RRMS in adult patients. The goal of this study was to extend these analyses to evaluate DMF in pediatric patients with RRMS.

Belimumab Nonsuperior to Placebo for Reducing Symptoms of Myasthenia Gravis

Belimumab Nonsuperior to Placebo for Reducing Symptoms of Myasthenia Gravis

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The investigators suggest that the recruited participants may have reached a plateau in symptoms, which may have decreased the chances of additional improvement with belimumab treatment.

Primary Periodic Paralysis: Advice for Clinicians & Future Directions

Primary Periodic Paralysis: Advice for Clinicians & Future Directions

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Neurology Advisor speaks with Annabelle Baughan, a retired hematologist-oncologist, and discusses her personal experience with Andersen-Tawil syndrome.

Efficacy of Disease-Modifying Drugs for Multiple Sclerosis May Decrease With Age

Efficacy of Disease-Modifying Drugs for Multiple Sclerosis May Decrease With Age

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A regression model showed that efficacy of DMTs significantly decreased until age 53, after which disease progression is not affected by DMTs.

Ozanimod Superior to Interferon β-1a for Treatment of Relapsing Multiple Sclerosis

Ozanimod Superior to Interferon β-1a for Treatment of Relapsing Multiple Sclerosis

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Researchers sought to compare the safety and efficacy of ozanimod vs interferon β-1a in individuals with relapsing multiple sclerosis.

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

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The new guidelines focus on helping clinicians decide when to initiate, switch, or discontinue disease-modifying therapies for multiple sclerosis.

Are Vaccines Associated With Multiple Sclerosis Relapse?

Are Vaccines Associated With Multiple Sclerosis Relapse?

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Researchers found there are no associations between vaccinations and multiple sclerosis relapse flares.

Cardiovascular Comorbidities Linked to Increased Brain Atrophy in Multiple Sclerosis

Cardiovascular Comorbidities Linked to Increased Brain Atrophy in Multiple Sclerosis

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Researchers investigated the association between cardiovascular risk factors and the development of brain atrophy in individuals with multiple sclerosis.

Switching to Oral Fingolimod From Injectable Treatment Linked to Fewer MS Relapses

Switching to Oral Fingolimod From Injectable Treatment Linked to Fewer MS Relapses

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As injectable disease-modifying therapies can be inconvenient for patients with MS, fingolimod offers an oral treatment option that is associated with significantly lower risk for relapse.

Interaction of Alcohol, Smoking on Multiple Sclerosis Severity

Interaction of Alcohol, Smoking on Multiple Sclerosis Severity

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A cross-sectional study aimed to assess the effect of smoking and alcohol consumption along with the interactions they have on the clinical course of multiple sclerosis.

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis

AAN: High Fish Intake Linked to Reduced Risk of Multiple Sclerosis

Compared with consuming fish less than once per month and no supplements, high fish intake was correlated with a significantly reduced risk of multiple sclerosis.

Scoliosis Surgery Found Beneficial for Cerebral Palsy Patients

Scoliosis Surgery Found Beneficial for Cerebral Palsy Patients

Scoliosis surgery in patients with cerebral palsy leads to a significant improvement in health-related quality of life.

Pinpointing Clinically Meaningful Change in Cervical Dystonia Treated With Botulinum Toxin

Pinpointing Clinically Meaningful Change in Cervical Dystonia Treated With Botulinum Toxin

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The administration of treatment was performed over 5 treatment cycles, and the investigators assessed TWSTRS changes at baseline and 4 weeks following injection.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

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Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

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