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The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

Geoffrey Littlejohn, MD, provides a clinical perspective on the pathophysiology of fibromyalgia and the role of neurogenic inflammation in the disease process.

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Short Segment Sensory Nerve Stimulation Offers Potential Diagnostic Value for Ulnar Neuropathy

Short Segment Sensory Nerve Stimulation Offers Potential Diagnostic Value for Ulnar Neuropathy

The use of short-segment stimulation along the ulnar sensory nerves and across the elbow may provide reliable diagnostic confirmation of ulnar neuropathies.

Transcutaneous Electrical Nerve Stimulation Reduces Pain, Fatigue in Fibromyalgia

Transcutaneous Electrical Nerve Stimulation Reduces Pain, Fatigue in Fibromyalgia

Transcutaneous electrical nerve stimulation administered during physical activity may effectively alleviate fibromyalgia-associated pain, fatigue, and disease impact in women.

Tegsedi Approved for Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis

Tegsedi Approved for Polyneuropathy of Hereditary Transthyretin-Mediated Amyloidosis

The approval was based on data from the Phase 3 NEURO-TTR study (N=173) which randomized patients with polyneuropathy caused by hATTR amyloidosis to Tegsedi or placebo.

Optimizing Treatment for Patients With Chronic Sciatica: Gabapentin vs Pregabalin

Optimizing Treatment for Patients With Chronic Sciatica: Gabapentin vs Pregabalin

In patients with chronic sciatica, gabapentin was associated with a greater reduction in leg pain intensity and fewer side effects compared with pregabalin.

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

FDA Fast-Tracks Non-Opioid Treatment for Neuropathic Pain

The treatment is currently being evaluated in a Phase 2 study (ELEVATE) in patients with major depressive disorder who have had an inadequate response to standard antidepressant therapy.

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Is Pregabalin Effective for Chronic, Post-Traumatic Neuropathic Pain?

Pregabalin does not appear to be effective for controlling pain in patients with chronic post-traumatic peripheral neuropathic pain.

ZTlido Patch for Post-Shingles Pain Launching Soon

ZTlido Patch for Post-Shingles Pain Launching Soon

The non-aqueous adhesive patch requires 36mg per topical system to achieve the same therapeutic dose as Lidoderm (lidocaine 5%) which contains 700mg per patch.

Increased Corticomotor Excitability ID'd in Restless Legs

Increased Corticomotor Excitability ID'd in Restless Legs

For patients with restless leg syndrome, the primary motor cortex (M1) exhibits hyperexcitability, which is associated with disease severity.

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

Trial Evaluating BCG Vaccine for Fibromyalgia Given Green Light by FDA

The investigators hope that the BCG vaccine can increase anti-inflammatory cytokines, which are deficient in patients with fibromyalgia.

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

Fingolimod Does Not Slow Worsening of Chronic Inflammatory Demyelinating Polyradiculoneuropathy

The trial was ended for futility when a total of 44 worsening events had occurred in the cohort.

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