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The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

The Role of Neurogenic Inflammation in Fibromyalgia Pathophysiology

Geoffrey Littlejohn, MD, provides a clinical perspective on the pathophysiology of fibromyalgia and the role of neurogenic inflammation in the disease process.

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Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

Electrophysiologic Features Specific to Transthyretin Familial Amyloid Polyneuropathies

Reduced amplitude of the ulnar motor nerve and the sural nerve action potentials may be specific to transthyretin familial amyloid polyneuropathies, allowing us to distinguish this disorder from other demyelinating polyneuropathies.

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

Various Factors Affect Progress in Back-Related Leg Pain, Sciatica

In back-related leg pain and sciatica patients, belief in a long recovery and the number of other symptoms attributed to the pain are independently negatively associated with improvement.

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

CAPPRI Scale is Feasible for Assessing Health-Related Quality of Life in Diabetic Distal Sensorimotor Polyneuropathy

Investigators evaluated the performance of the CAPPRI in assessing health-related quality-of-life outcomes in patients with diabetic distal sensorimotor polyneuropathy.

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

Mirtazapine for Fibromyalgia: An Effective Treatment Option?

Mirtazapine is a central alpha-2 antagonist currently FDA-approved for the treatment of major depressive disorder.

Morphologic Changes in Primary Somatosensory System May Fuel Restless Leg Symptoms

Morphologic Changes in Primary Somatosensory System May Fuel Restless Leg Symptoms

Compared with control patients, patients with restless leg syndrome symptoms experienced a morphologic change in the brain somatosensory system.

Peripheral Neuropathy Common in Childhood Cancer Survivors

Peripheral Neuropathy Common in Childhood Cancer Survivors

Childhood cancer survivors frequently have clinical abnormalities attributable to peripheral neuropathy.

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

Distinct Mechanisms Underlie Nerve Damage in Peripheral Neuropathy in Type 1 vs Type 2 Diabetes

The type of sciatic nerve lesions observed in patients with diabetic peripheral neuropathy was found to differ in type 1 and type 2 diabetes.

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Clinical and Research Applications of Screening and Assessment Questionnaires for Neuropathic Pain

Specific countries officially recommend some screening questionnaires for the early assessment of neuropathic pain, with France recommending the DN4 and Germany recommending PainDETECT.

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

Tai Chi Beats Aerobic Exercise in Fibromyalgia

Tai Chi Beats Aerobic Exercise in Fibromyalgia

Improvement in fibromyalgia impact questionnaire scores was greater for combined tai chi groups.

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