Neuropathic Pain

Restless Legs Syndrome Associated With Increased Cardiovascular Mortality

Restless Legs Syndrome Associated With Increased Cardiovascular Mortality

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Women with RLS are more likely to have cardiovascular-related comorbidities than those without RLS.

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

FDA Reviewing NDA for Hereditary aTTR Amyloidosis Gene-Silencing Therapy

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The FDA has accepted Alnylam's New Drug Application for patisiran, and investigational drug for treating hereditary aTTR amyloidosis, for priority review.

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

Charcot-Marie-Tooth Disease Severity Indicated by Plasma Neurofilament Concentration

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The measurement may provide a dynamic measure of axonal damage in a disease in which neuropathy is the only neurologic manifestation.

Guidelines: Opioids for the Treatment of Refractory Restless Legs Syndrome

Guidelines: Opioids for the Treatment of Refractory Restless Legs Syndrome

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For patients with restless leg syndrome, opioids may be very beneficial if taken in low daily doses.

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Spinal Cord Stimulation Reduces Pain Associated With Diabetic Polyneuropathy

Chronic pain symptoms in patients with PDPN are effectively reduced with spinal cord stimulation.

Acupuncture Relieves Pain Associated With Trigeminal Neuralgia

Acupuncture Relieves Pain Associated With Trigeminal Neuralgia

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Secondary myofascial pain and mandibular limitations were reduced in the acupuncture and sham acupuncture groups immediately after treatment.

Improving Outcomes of Peripheral Nerve Surgery

Improving Outcomes of Peripheral Nerve Surgery

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Although peripheral nerve decompression has been found to be effective in relieving some symptoms for burn patients, there is still some uncertainty.

Diagnosing Fibromyalgia in Chronic Pain Patients With Simple Exams

Diagnosing Fibromyalgia in Chronic Pain Patients With Simple Exams

A probable diagnosis of fibromyalgia can be indicated with 2 simple tests in chronic pain patients.

Virtual Reality May Provide Neuropathic Pain Relief for Spinal Cord Injury

Virtual Reality May Provide Neuropathic Pain Relief for Spinal Cord Injury

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Virtual reality and multisensory stimulation could play a role in rehabilitation for patients with spinal cord injury.

Peripheral Neuropathy After Chemotherapy: Mechanism Identified

Peripheral Neuropathy After Chemotherapy: Mechanism Identified

The mechanism for chemotherapy-induced peripheral neuropathy may have been uncovered.

Multiple Sclerosis Lesion Location Linked to Hyperalgesia, Hypoalgesia

Multiple Sclerosis Lesion Location Linked to Hyperalgesia, Hypoalgesia

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In patients with multiple sclerosis, lesions in the right dorsolateral prefrontal cortex may be associated with hypoalgesia, and lesions in the posterior periventricular area, with hyperalgesia.

Sensory Neuropathy Common After Adjuvant Chemotherapy

Sensory Neuropathy Common After Adjuvant Chemotherapy

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Chemotherapy-associated chronic pain and neuropathy have substantial impacts on patients' lives.

FDA Approves Neuropathic Pain Treatment

FDA Approves Neuropathic Pain Treatment

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The FDA has approved a treatment for 2 neuropathic pain conditions.

Neuroinflammation in Neuropathic Pain Signaled by Chemokine Levels in CSF

Neuroinflammation in Neuropathic Pain Signaled by Chemokine Levels in CSF

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To explore common mediators of neuropathic pain, the investigators suggest future studies should examine common comorbidities, such as anxiety, depression, tiredness, and poor sleep, in people with neuropathic pain.

Neuropathic Pain Linked to Vitamin Deficiency in Rheumatoid Arthritis

Neuropathic Pain Linked to Vitamin Deficiency in Rheumatoid Arthritis

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Vitamin D deficiency was shown to be associated with increased neuropathic pain in RA patients.

Restless Leg Syndrome Equally Responsive to Multiple Drug Classes

Restless Leg Syndrome Equally Responsive to Multiple Drug Classes

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Few head-to-head trials have been conducted that have compared different classes of drugs for treatment of RLS.

FDA Approves Demyelinating Polyneuropathy Treatment

FDA Approves Demyelinating Polyneuropathy Treatment

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Privigen is a ready-to-use liquid intravenous immune globulin product stabilized with proline.

Comparing Treatments for Painful Diabetic Neuropathy

Comparing Treatments for Painful Diabetic Neuropathy

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Rates of painful diabetic neuropathy are increasing along with the prevalence of diabetes.

Opioid Combination Improves Quality of Life in Fibromyalgia With PTSD

Opioid Combination Improves Quality of Life in Fibromyalgia With PTSD

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Opioid therapy was shown to improve quality of life in patients with comorbid fibromyalgia and PTSD.

Higher Doses of Pregabalin for Neuropathic Pain: Is it Safe?

Higher Doses of Pregabalin for Neuropathic Pain: Is it Safe?

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If patients with neuropathic pain don't respond to a low dose of pregabalin, they may benefit from a higher dose.

Surgical Nerve Decompression May Improve Restless Leg Syndrome

Surgical Nerve Decompression May Improve Restless Leg Syndrome

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RLS symptoms can be improved by nerve decompression for peripheral neuropathy.

Fibromyalgia May Benefit From Aerobic Exercise

Fibromyalgia May Benefit From Aerobic Exercise

Aerobic exercise appeared to benefit health-related quality of life in patients with fibromyalgia.

Gabapentinoid Prescribing Trends: Are We Using Too Much?

Gabapentinoid Prescribing Trends: Are We Using Too Much?

As a response to the opioid epidemic, clinicians may be overprescribing gabapentinoids.

Fibromyalgia, Chronic Pain Impacted By Childhood Adversity

Fibromyalgia, Chronic Pain Impacted By Childhood Adversity

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Childhood adversity levels are increased in female patients with fibromyalgia and chronic pain.

Update: Diagnosing Neuropathic Pain in Stroke, MS, Spinal Cord Injury

Update: Diagnosing Neuropathic Pain in Stroke, MS, Spinal Cord Injury

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The update focused on diagnosis of neuropathic pain in patients with spinal cord injury, stroke, or multiple sclerosis.

Long-Term Opioid Therapy Tied to Worse Outcomes in Polyneuropathy

Long-Term Opioid Therapy Tied to Worse Outcomes in Polyneuropathy

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Most prescriptions for long-term opioid therapy were written by internal or family medicine physicians.

Peripheral Nerve Stimulation Effective for Postherpetic Neuralgia

Peripheral Nerve Stimulation Effective for Postherpetic Neuralgia

PNS can be beneficial for chronic intractable pain secondary to postherpetic neuralgia.

Evaluating Orexin Antagonist for Diabetic Neuropathy Tx

Evaluating Orexin Antagonist for Diabetic Neuropathy Tx

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Researchers are looking into improving sleep in order to alleviate chronic pain.

Gabapentin Effective for Postherpetic Neuralgia, Neuropathy

Gabapentin Effective for Postherpetic Neuralgia, Neuropathy

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Patients suffering from postherpetic nearalgia found relief taking gabapentin.

Patients With Fibromyalgia, Depression May Benefit From Pregabalin

Patients With Fibromyalgia, Depression May Benefit From Pregabalin

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Although there is currently no gold standard therapy for the treatment of fibromyalgia, a number of medications have shown modest efficacy in managing fibromyalgia-related pain, including pregabalin.

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