Opioids

Quantity of Opioids Prescribed Postop Linked to Consumption

Quantity of Opioids Prescribed Postop Linked to Consumption

The quantity of opioids prescribed after surgery is associated with patient-reported opioid consumption.

US Opioid Overdose Deaths Reach Record Number

US Opioid Overdose Deaths Reach Record Number

The number of opioid overdose deaths in the United States reached a new record last year with 72,000 deaths, which works out to about 200 a day.

FDA Approves Powerful New Opioid Despite Criticisms

FDA Approves Powerful New Opioid Despite Criticisms

Ruling against the recommendation of one of its chief experts, the US FDA approved an extremely potent new opioid painkiller, Dsuvia.

Opioid Use Often Persists in Workers' Compensation Claimants

Opioid Use Often Persists in Workers' Compensation Claimants

Many patients in a workers' compensation cohort have persistent opioid use.

Bill to Fight US Opioid Crisis Signed Into Law

Bill to Fight US Opioid Crisis Signed Into Law

A bipartisan bill meant to combat the United States' opioid abuse epidemic was signed into law October 24 by President Donald Trump.

Risk of Opioid-Benzodiazepine Overlap Up for Dual Prescribing

Risk of Opioid-Benzodiazepine Overlap Up for Dual Prescribing

Receiving prescriptions from both the US Department of Veterans Affairs and Medicare Part D is associated with increased risk for overlapping of opioid and benzodiazepine prescriptions.

Congress Passes Bill to Fight Opioid Crisis

Congress Passes Bill to Fight Opioid Crisis

A bipartisan bill to fight the opioid addiction crisis in the United States has been passed by Congress.

Opioid Use Down With 'Enhanced Recovery After Surgery' Program

Opioid Use Down With 'Enhanced Recovery After Surgery' Program

An "enhanced recovery after surgery" program is associated with a significant reduction in opioid consumption after gynecologic surgery with no increase in pain scores.

Opioid Bill Gets Bipartisan Support

Opioid Bill Gets Bipartisan Support

In a rare bipartisan move, both the House and Senate have reached a compromise on legislation to address the opioid epidemic.

Potentially Inappropriate Opioid Prescribing Tied to Overdose

Potentially Inappropriate Opioid Prescribing Tied to Overdose

Potentially inappropriate prescribing (PIP) of opioids is associated with increased risk of all-cause mortality and fatal and nonfatal overdose.

FDA: Opioid Analgesic REMS Expanded to Include Immediate-Release Products

FDA: Opioid Analgesic REMS Expanded to Include Immediate-Release Products

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As part of the REMS program, drug companies with approved opioid analgesics must make training available to prescribers and provide unrestricted grants to accredited continuing education providers for the development of education courses.

Opioids Often Prescribed in the Absence of Pain Diagnosis

Opioids Often Prescribed in the Absence of Pain Diagnosis

Many outpatient opioid prescriptions have no documented medical indication.

Oxycontin's Maker Now Selling Drug to Curb Opioid Addiction

Oxycontin's Maker Now Selling Drug to Curb Opioid Addiction

Purdue Pharma, the maker of Oxycontin who some have blamed for the epidemic of opioid painkiller addictions, has patented a medicine aimed at curbing those disorders.

With New Persistent Opioid Use, Most Early Scripts From Surgeons

With New Persistent Opioid Use, Most Early Scripts From Surgeons

Among surgical patients who develop new persistent opioid use, surgeons provide the majority of opioid prescriptions in the first few months after surgery.

Opioid Maker to Pay for Overdose Antidote Development

Opioid Maker to Pay for Overdose Antidote Development

A $3.4 million grant to help a non-profit company develop a less expensive opioid overdose antidote was announced by Purdue Pharma, which makes the opioid painkiller OxyContin.

Pregabalin may increase the risk of death when coprescribed with opioids

Patients coprescribed opioids and pregabalin had significantly increased odds of opioid-related death compared to opioid prescription alone.

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

FDA Outlines Plan for New Analgesic Guidance to Combat Opioid Crisis

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The new plan will break out the current guidance into 4 separate guidances.

US Opioid Use Not Declining, Despite Focus on Abuse

US Opioid Use Not Declining, Despite Focus on Abuse

Rates of opioid use in the United States do not appear to be declining.

FDA Warning Letters Target Illegal Online Sales of Opioids

FDA Warning Letters Target Illegal Online Sales of Opioids

Four more online networks that operate 21 websites illegally selling potentially dangerous, unapproved, and misbranded versions of opioid pain medications have been told to immediately stop their sales.

Odds of Death Up With Exposure to Pregabalin, Opioids

Odds of Death Up With Exposure to Pregabalin, Opioids

Concomitant exposure to pregabalin and opioids is associated with increased odds of opioid-related death.

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

DEA Proposal Will Significantly Cut Opioid Manufacturing in 2019

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Last year, the DEA proposed a 20% reduction in the manufacturing of controlled substances for 2018 compared to 2017.

Outpatient Opioid Prescriptions for Children Often Filled

Outpatient Opioid Prescriptions for Children Often Filled

Children often fill outpatient opioid prescriptions, with the most common indication for dental procedures.

NIH Initiative Aims to Address Opioid Misuse Over Long Term

NIH Initiative Aims to Address Opioid Misuse Over Long Term

A novel, innovative initiative is being developed to help end addiction over the long term.

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Meds for Opioid Use Disorder May Reduce Mortality in OD Survivors

Use of medications for opioid use disorder is associated with a reduction in all-cause and opioid-related mortality after opioid overdose.

Illicit Opioid Trade Up With Restrictions on Hydrocodone

Illicit Opioid Trade Up With Restrictions on Hydrocodone

The US Drug Enforcement Administration's 2014 ruling to reschedule hydrocodone combination products coincided with an increase in illicit trading of opioids through online illicit markets.

FDA Warns Websites Marketing Unapproved Opioids

FDA Warns Websites Marketing Unapproved Opioids

Nine online networks have been warned that they must stop illegally marketing potentially dangerous, and misbranded versions of opioid medications.

FDA: Opioid Antidote Naloxone Recalled

FDA: Opioid Antidote Naloxone Recalled

A recall of the opioid overdose antidote Naloxone was announced Monday.

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

NDA for First-of-Its-Kind Opioid Analgesic Submitted to FDA

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A NDA has been submitted for NKTR-181, an opioid analgesic molecule designed to provide pain relief with fewer CNS-mediated side effects.

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

Study IDs Unintended Consequence of Prescription Drug Monitoring Programs

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Evidence on whether the implementation of prescription drug monitory programs increases or decreases opioid-related overdoses was found to be "largely insufficient".

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

Suicidal Behavior Increased With Opioids, Psychotropic Medication Misuse in Epilepsy

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Investigators conducted a population-based study to assess risk and cause of unnatural mortality in individuals with epilepsy.

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