Parkinson's Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

Lifestyle Factors, Family History Linked to Overall Risk for Parkinson Disease

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Risk factors for all study participants were calculated on the basis of the following factors known to be previously linked to PD risk: total caffeine intake, smoking, physical activity, and family history of PD.

IBD Associated With Increased Incidence of Parkinson Disease

IBD Associated With Increased Incidence of Parkinson Disease

Patients with IBD who were exposed to anti-TNF therapy had a significant decrease in incidence of PD.

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

Acadia Addresses Concerns Over Nuplazid Safety in Parkinson Disease Patients

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Concerns over Nuplazid were initially voiced in a CNN article in early April which reported that the drug had been associated with over 700 deaths since its launch in March 2017.

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

Exposure to Anti-TNF Therapy Linked to Reduced Parkinson Disease Risk

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Previous research has suggested a genetic and functional link between IBD and PD, however evidence regarding this association has been limited.

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

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Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

Understanding Impulse Control Disorders in Parkinson Disease: Developments and Treatments

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In this article, we explore research findings to provide a deeper understanding of the factors associated with increased risk for impulse control disorders in Parkinson disease. Deputy Director of the Parkinson's UK charity, Professor David Dexter, also provides insights on the mechanisms of impulse control disorders and the implications of new findings on the management of Parkinson disease.

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

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Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

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Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

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Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

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Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

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The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

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It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

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The FDA has approved Osmolex ER for the treatment of Parkinson disease.

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

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A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

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By 10 weeks, participants in the treatment group reported significant improvements in quality of life.

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine Film Effectively Treats Off State in Parkinson Disease

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Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.

Gait Stability in Parkinson's Improved With Robotic Training

Gait Stability in Parkinson's Improved With Robotic Training

In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

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Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

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Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

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The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.

Deep Brain Stimulation Improves Survival in Parkinson Disease

Deep Brain Stimulation Improves Survival in Parkinson Disease

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Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Patient's with depression that have Parkinson's disease have impaired white matter integrity.

Men With Parkinson Disease More Likely to Have Caregiver

Men With Parkinson Disease More Likely to Have Caregiver

More men with Parkinson's disease have caregivers than women.

Predicting Rates and Patterns of Progression in Parkinson Disease

Predicting Rates and Patterns of Progression in Parkinson Disease

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Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.

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