Parkinson's Disease

AAN: Alpha-Synuclein Levels in Tears May Help ID Parkinson's

AAN: Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

Demoralization Common in Patients With Parkinson Disease

Demoralization Common in Patients With Parkinson Disease

Demoralization is common in patients with Parkinson disease and is associated with motor dysfunction.

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

Neurosurgery in Parkinson Disease: A Brief History and Look Forward

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Although deep brain stimulation, similar to all Parkinson disease therapies, cannot cure, modify, or slow progression of the disease, some recent research suggests that the symptom alleviation and quality-of-life improvement it provides might lead to mild improvements in longevity.

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

Montreal Parkinson Risk of Dementia Scale Deemed Accurate

The office-based, eight-item Montreal Parkinson Risk of Dementia Scale is a valid predictor of development of dementia.

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

NDA Submitted for Sublingual Film to Treat OFF Episodes in Parkinson's Disease

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Sunovion announced the submission of its New Drug Application for apomorphine sublingual film for OFF episodes linked with PD.

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

Idiopathic Parkinson Disease May Increase Risk for Overactive Bladder

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Idiopathic Parkinson disease is independently associated with an increased risk for overactive bladder.

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

Atypical FDG-PET Patterns Predict Higher Dementia Risk in Parkinson Disease

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Investigators sought to determine whether brain pattern metabolic alterations in PD and FDG-PET SPM could predict dementia risk.

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

Bilateral Subthalamic Stimulation Improves Outcomes in Parkinson's With Early Motor Complications

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The use of subthalamic stimulation may be beneficial in managing psychobehavioral manifestations of Parkinson disease.

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

Gait Difficulty in Parkinson Disease May Be Associated With More Progressive Disease Course

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It may be best to deal with the PD subtype characterized by gait difficulty differently from the akinetic-rigid subtype.

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

FDA Approves Extended Release Amantadine for Parkinson Disease, Extrapyramidal Reactions

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The FDA has approved Osmolex ER for the treatment of Parkinson disease.

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

Comparing Reference Points for Deep Brain Stimulation Location in Parkinson Disease

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A significant negative correlation was found between the individual Unified Parkinson's Disease Rating Scale motor improvement and the Euclidean distance from the stimulation center to the deep brain stimulation "hotspot" when using the medial subthalamic nucleus border as an anatomical reference.

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

Motor, Cognitive Rehabilitation Program May Improve Quality of Life in Parkinson Disease

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By 10 weeks, participants in the treatment group reported significant improvements in quality of life.

Apomorphine Film Effectively Treats Off State in Parkinson Disease

Apomorphine Film Effectively Treats Off State in Parkinson Disease

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Apomorphine sublingual film showed superior efficacy for on-demand treatment of OFF episodes in patients with Parkinson's.

Gait Stability in Parkinson's Improved With Robotic Training

Gait Stability in Parkinson's Improved With Robotic Training

In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

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Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

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Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

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The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.

Deep Brain Stimulation Improves Survival in Parkinson Disease

Deep Brain Stimulation Improves Survival in Parkinson Disease

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Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Patient's with depression that have Parkinson's disease have impaired white matter integrity.

Men With Parkinson Disease More Likely to Have Caregiver

Men With Parkinson Disease More Likely to Have Caregiver

More men with Parkinson's disease have caregivers than women.

Predicting Rates and Patterns of Progression in Parkinson Disease

Predicting Rates and Patterns of Progression in Parkinson Disease

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Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

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Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

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Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.

Parkinson Disease Onset Linked to <i>LRRK2</i> Variants

Parkinson Disease Onset Linked to LRRK2 Variants

There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.

Patients With Parkinson Disease Are at High Risk for Depression

Patients With Parkinson Disease Are at High Risk for Depression

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Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.

Drug May Help Improve Daytime Sleepiness in Parkinson's

Drug May Help Improve Daytime Sleepiness in Parkinson's

Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

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Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.

Smoking Modifies Genetic Link to Parkinson Disease

Smoking Modifies Genetic Link to Parkinson Disease

Smoking may modify a genetic link with Parkinson disease.

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