In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.
Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.
In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.
Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.
Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.
The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.
Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.
Patient's with depression that have Parkinson's disease have impaired white matter integrity.
More men with Parkinson's disease have caregivers than women.
Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.
Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.
Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.
There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.
Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.
Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.
Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.
Smoking may modify a genetic link with Parkinson disease.
While parkinsonian disorders share a common mechanism of protein aggregation, manifestations are quite varied.
The investigators suggested that the models should be recalibrated based on geographic location for more individualized predictions.
Cognitive dysfunction may be a sign of prodromal Parkinson disease.
Abnormal beta synchrony in the Parkinsonian basal ganglia is suppressed by bicycling.
The highest incidence rates of adverse effects in PD were linked with ropinirole, bromocriptine, and piribedil.
A poor sense of smell is linked with an increased risk for Parkinson's disease.
β-2 adrenergic agonists might be able to fight Parkinson's disease.
Patients with postural instability and gait disturbances had worse sleep scores than those with tremor-dominant Parkinson's.
Enrollment of patients with only early Parkinson's disease in this trial prevents generalization of the study's findings across the entire Parkinson's population.
Patients with both Parkinson's and rapid eye movement sleep behavior disorder were much more likely to experience mild cognitive impairment.
Patients taking levodopa therapy may experience neuropsychiatric fluctuations characterized by changes in mood, motivation, and anxiety while in ON and OFF states of drug therapy.
For patient's with Parkinson's disease, virtual house calls from neurologists may be of interest.
In a disease where there have been few therapeutic developments since dopamine, exenatide offers a promising new channel of exploration.
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