Parkinson's Disease

Gait Stability in Parkinson's Improved With Robotic Training

Gait Stability in Parkinson's Improved With Robotic Training

In patients with Parkinson disease, cable-driven robot training is linked with improved response to perturbations and increased gait stability.

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Parkinson Disease Dementia Does Not Benefit From Deep Brain Stimulation

Deep brain stimulation does not show significant improvements in cognitive outcomes for patients with Parkinson disease dementia.

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

Amyloid, Tau Patterns in Parkinson's Do Not Differ Based on Cognitive Status

In Parkinson's patients who are cognitively normal or have mild cognitive impairment, patterns of cortical β-amyloid and tau are not different.

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

Motor-Cognitive Dual Task Not Associated With Cognitive Dysfunction in Parkinson's

By

Investigators determined the association between motor-cognitive dual task gait performance and cognitive impairment.

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

Sex Differences in Parkinson Disease: Implications for Diagnosis, Treatment

By

Several studies have uncovered sex-dependent variations in the symptomatic manifestations of Parkinson disease, as well as in the response to dopamine therapies.

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

FDA Approves Vercise Deep Brain Stimulation System for Parkinson Disease

By

The FDA has approved the Vercise Deep Brain Stimulation System for the treatment of Parkinson disease.

Deep Brain Stimulation Improves Survival in Parkinson Disease

Deep Brain Stimulation Improves Survival in Parkinson Disease

By

Compared with patients undergoing medical management, patients who underwent deep brains stimulation had more than a 30% reduced risk for mortality.

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Depression in Parkinson Disease Linked to Impaired White Matter Integrity

Patient's with depression that have Parkinson's disease have impaired white matter integrity.

Men With Parkinson Disease More Likely to Have Caregiver

Men With Parkinson Disease More Likely to Have Caregiver

More men with Parkinson's disease have caregivers than women.

Predicting Rates and Patterns of Progression in Parkinson Disease

Predicting Rates and Patterns of Progression in Parkinson Disease

By

Numerous factors are likely contribute to the rate of progression, with different combinations of factors showing relevance for individual patients.

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

Parkinson Disease Onset Associated With Reductions in Migraine Frequency, Severity

By

Patients with Parkinson disease had reductions in the intensity, frequency and overall severity of their headaches and migraines.

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

Reports of Agranulocytosis Prompt Monitoring for Investigational Parkinson's Drug

By

Tozadenant is being investigated as an adjunctive treatment to levodopa in Parkinson disease patients to reduce 'off' time.

Parkinson Disease Onset Linked to <i>LRRK2</i> Variants

Parkinson Disease Onset Linked to LRRK2 Variants

There is a younger age at onset of Parkinson disease linked with the presence of LRRK2 risk variants.

Patients With Parkinson Disease Are at High Risk for Depression

Patients With Parkinson Disease Are at High Risk for Depression

By

Female sex, dependency, high pain scores, and lower Mini-Mental State Examination scores were correlated with higher depression scores.

Drug May Help Improve Daytime Sleepiness in Parkinson's

Drug May Help Improve Daytime Sleepiness in Parkinson's

Sodium oxybate seems to be effective for patients with Parkinson disease and excessive daytime sleepiness.

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

Asleep Deep Brain Stimulation Linked to Better Outcomes in Parkinson's

By

Deep brain stimulation is traditionally conducted with the patient awake in order to help the ideal target for electrode placement.

Smoking Modifies Genetic Link to Parkinson Disease

Smoking Modifies Genetic Link to Parkinson Disease

Smoking may modify a genetic link with Parkinson disease.

Atypical Parkinsonian Disorders: Reviewing the Complex Web of Proteinopathies

Atypical Parkinsonian Disorders: Reviewing the Complex Web of Proteinopathies

By

While parkinsonian disorders share a common mechanism of protein aggregation, manifestations are quite varied.

Prognostic Models for Predicting Death and Dependency in Parkinson's

Prognostic Models for Predicting Death and Dependency in Parkinson's

By

The investigators suggested that the models should be recalibrated based on geographic location for more individualized predictions.

Parkinsonism Diagnosis Linked to Cognitive Deficits

Parkinsonism Diagnosis Linked to Cognitive Deficits

By

Cognitive dysfunction may be a sign of prodromal Parkinson disease.

Cycling Overloads Movement Networks Impacted by Parkinson Disease

Cycling Overloads Movement Networks Impacted by Parkinson Disease

Abnormal beta synchrony in the Parkinsonian basal ganglia is suppressed by bicycling.

Parkinson Drugs With Highest Adverse Effect Rates

Parkinson Drugs With Highest Adverse Effect Rates

The highest incidence rates of adverse effects in PD were linked with ropinirole, bromocriptine, and piribedil.

Increased Parkinson's Risk Associated With Poor Sense of Smell

Increased Parkinson's Risk Associated With Poor Sense of Smell

A poor sense of smell is linked with an increased risk for Parkinson's disease.

β-2 Adrenergic Agonists Linked to α-synuclein Transcription and Risk of PD

β-2 Adrenergic Agonists Linked to α-synuclein Transcription and Risk of PD

β-2 adrenergic agonists might be able to fight Parkinson's disease.

Parkinson's: Sleep Disturbances Affect Clinical Motor Subtypes, Disability

Parkinson's: Sleep Disturbances Affect Clinical Motor Subtypes, Disability

By

Patients with postural instability and gait disturbances had worse sleep scores than those with tremor-dominant Parkinson's.

Age, Gender, and Cognition Predict Weight Loss in Parkinson's Disease

Age, Gender, and Cognition Predict Weight Loss in Parkinson's Disease

By

Enrollment of patients with only early Parkinson's disease in this trial prevents generalization of the study's findings across the entire Parkinson's population.

Parkinson's, REM Sleep Disorder Combination Linked to Cognitive Decline

Parkinson's, REM Sleep Disorder Combination Linked to Cognitive Decline

By

Patients with both Parkinson's and rapid eye movement sleep behavior disorder were much more likely to experience mild cognitive impairment.

Levodopa-Induced Euphoria May Drive Addictions, Behavior in Parkinson's

Levodopa-Induced Euphoria May Drive Addictions, Behavior in Parkinson's

By

Patients taking levodopa therapy may experience neuropsychiatric fluctuations characterized by changes in mood, motivation, and anxiety while in ON and OFF states of drug therapy.

Remote Neurological Care a Feasible Option for Parkinson's Disease

Remote Neurological Care a Feasible Option for Parkinson's Disease

For patient's with Parkinson's disease, virtual house calls from neurologists may be of interest.

Exenatide Presents Exciting Therapeutic Possibilities for Parkinson's Disease

Exenatide Presents Exciting Therapeutic Possibilities for Parkinson's Disease

By

In a disease where there have been few therapeutic developments since dopamine, exenatide offers a promising new channel of exploration.

Sign Up for Free e-newsletters

CME Focus