Zika Infection in Late Pregnancy Can Still Affect Fetal Brain
In addition, a second study found that Zika infection can be spread through organ transplants.
HealthDay News — The Zika virus may harm an infant's brain even if the mother is infected just before giving birth, according to a study published online Sept. 6 in Clinical Infectious Diseases.
The new study included 55 Brazilian women infected by Zika during pregnancy and their infants. Medical imaging revealed that 4 infants whose mothers were infected with Zika between 2 weeks and 1 week before birth had central nervous system lesions characteristic of viral infections.
"These infants were born with normal length and weight, and without microcephaly or any other symptoms of the disease. The lesions would have gone unnoticed by health workers if the mothers hadn't been part of a study group," lead researcher Mauricio Lacerda Nogueira, MD, PhD, a professor at the Sao Jose do Rio Preto Medical School (FAMERP), in Sao Paulo State, and a member of the state's Zika Virus Research Network, said in a FAMERP news release. "We mean to keep monitoring the development of these babies for several years in order to detect any problems."
Another study by FAMERP researchers and led by Nogueira found that Zika infection can be spread through organ transplants. They identified 2 kidney transplant patients and 2 liver transplant patients who were infected with Zika that was present in their new organs. The study was published online Oct. 11 in the American Journal of Transplantation. All 4 patients had to be hospitalized but survived. "These transplant recipients didn't have the typical symptoms of Zika, such as exanthema, itching, and conjunctivitis," Nogueira said.
1. de Souza AS, Dias CM, Braga F, et al. Fetal infection by Zika virus in the third trimester: report of 2 cases. Clin. Infect. Dis. 2016; doi:10.1093/cid/ciw613.
2. Nogueira ML, Estofolete CF, Terzian ACB, et al. Zika virus infection and solid organ transplantation: a new challenge. Am. J. Transplant. 2016; doi:10.1111/ajt.14047.