Seizures

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

Chronic Traumatic Encephalopathy Uncommon in Treatment-Refractory Epilepsy

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While epilepsy-related head trauma was common, 9 of 10 patients displayed no evidence of CTE.

FDA Approves Smart Watch for Epilepsy Management

FDA Approves Smart Watch for Epilepsy Management

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The FDA has cleared the Embrace smart watch for managing epilepsy.

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Cannabidiol Reduces Drop Seizures in Lennox-Gastaut Syndrome

Add-on cannabidiol is associated with reduced monthy drop seizure frequency in patients with Lennox-Gastaut sydrome associated drop seizures.

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

High Doses of Topiramate for Epilepsy in Pregnancy Increase Risks for Oral Clefts in Offspring

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Women receiving topiramate for epilepsy were exposed to high cumulative doses, increasing the risk for oral clefts in offspring.

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

Seizure Control Diminishes With Subsequent Antiepileptic Drug Therapy

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Patients with tough-to-treat seizures may require nonpharmacologic treatment such as resective surgery.

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

More Than One-Third of New Cases of Epilepsy Are Treatment Refractory

Over one-third of patients with newly diagnosed epilepsy do not respond to antiepileptic drug treatment.

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

Treating Levetiracetam-Induced Behavioral Effects With Vitamin B6

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Vitamin B6 was found to effectively treat the behavioral adverse effects seen with levetiracetam.

Myoclonus Reported With Gabapentin, Pregabalin Use

Myoclonus Reported With Gabapentin, Pregabalin Use

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Research has found that gabapentin and pregabalin induced myoclonus is often seen but is rarely documented.

Evaluating Antiepileptic Drug Safety in Elderly Patients

Evaluating Antiepileptic Drug Safety in Elderly Patients

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Lamotrigine and levetiracetam are just as effective as other AEDs, and are better tolerated as well.

Cannabidiol Under Priority Review for Treatment of Lennox-Gastaut, Dravet Syndromes

Cannabidiol Under Priority Review for Treatment of Lennox-Gastaut, Dravet Syndromes

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The FDA has accepted for filing with Priority Review the NDA for cannabidiol as seizure treatment.

Severe Refractory Focal Epilepsy May Benefit From Add-On Perampanel

Severe Refractory Focal Epilepsy May Benefit From Add-On Perampanel

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In patients with severe refractory focal epilepsy, add-on treatment with perampanel may be beneficial.

Identifying Pediatric Seizures With Hemispheric Regional Cerebral Oxygen Saturation

Identifying Pediatric Seizures With Hemispheric Regional Cerebral Oxygen Saturation

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The findings further the utility of cerebral oximetry as a neurological assessment tool.

Reducing Seizure Frequency in Dravet Syndrome With Low-Dose Fenfluramine

Reducing Seizure Frequency in Dravet Syndrome With Low-Dose Fenfluramine

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ZX008 has received Orphan Drug designation and Fast Track designation by the FDA for the treatment of Dravet syndrome.

Effect of Maternal Antibiotic Use on Neonatal Seizure Risk

Effect of Maternal Antibiotic Use on Neonatal Seizure Risk

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Researchers from the University of Colorado reported on whether or not maternal antibiotic use during labor increased the risk of seizure for the neonate.

Seizure Incidence Stable in Prostate Cancer Treated With Enzalutamide

Seizure Incidence Stable in Prostate Cancer Treated With Enzalutamide

Treatment with enzalutamide for metastatic castration-resistant prostate cancer patients is not linked with increased seizure incidence.

Vigabatrin Beneficial for Focal Seizures in Tuberous Sclerosis Complex

Vigabatrin Beneficial for Focal Seizures in Tuberous Sclerosis Complex

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Vigabatrin may be an effective option for patients with seizures due to tuberous sclerosis who do not respond to other anti-seizure treatments.

Initial Treatment With Ethosuximide Improves Behavioral Outcomes in Childhood Absence Epilepsy

Initial Treatment With Ethosuximide Improves Behavioral Outcomes in Childhood Absence Epilepsy

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A study assessed longitudinal behavior in pediatric patients with childhood absence epilepsy and made recommendations regarding initial preferred monotherapy.

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

Clobazam Effective for Refractory Epilepsy in Children Younger Than 2

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Clobazam is currently FDA-approved for the treatment of seizures associated with Lennox-Gastaut syndrome in children 2 years and older.

Foramen Ovale EEG Identifies Epileptogenic Zone in Mesial Temporal Lobe Epilepsy

Foramen Ovale EEG Identifies Epileptogenic Zone in Mesial Temporal Lobe Epilepsy

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The diagnostic tool may be especially useful in cases of nonlesional mesial temporal lobe epilepsy.

Alternative Therapies Improve Seizure Frequency, Quality of Life in Treatment-Refractory Epilepsy

Alternative Therapies Improve Seizure Frequency, Quality of Life in Treatment-Refractory Epilepsy

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Patients with refractory epilepsy who fail to benefit from 2 or more AEDs should be referred to alternative therapies.

Brainstem Damage in Epilepsy May Be Biomarker for Increased SUDEP Risk

Brainstem Damage in Epilepsy May Be Biomarker for Increased SUDEP Risk

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Patients who died from suspected SUDEP had extensive damage to areas of the mid-brain and brainstem that control autonomic function.

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

Continuous Infusion in Refractory Status Epilepticus Linked to Increased Mortality, Longer Hospital Stay

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Researchers compared outcomes between patients treated with continuous infusion or repeated doses of nonbenzodiazepine anti-seizure medication.

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

Cannabidiol Effective for Reducing Drop Seizures in Lennox-Gastaut Syndrome Regardless of Clobazam Use

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The study was a post-hoc analysis of responders who were on or off concomitant clobazam.

Signficant Risk of Seizures After Stroke Treatment With Reperfusion Therapies

Signficant Risk of Seizures After Stroke Treatment With Reperfusion Therapies

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Patients undergoing treatment for ischemic stroke are at greater risk for seizure development.

Seizure Frequency Predicts Neuropsychiatric Outcomes in BECTS

Seizure Frequency Predicts Neuropsychiatric Outcomes in BECTS

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Researchers examined whether there are clinical features or treatments associated with neuropsychiatric outcomes in BECTS.

Bone Mineral Density Loss Prevention Needed in Epilepsy

Bone Mineral Density Loss Prevention Needed in Epilepsy

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Treatment algorithms are needed for patients with epilepsy who present with evidence of bone loss.

Positive Airway Pressure Improves Seizure Control in Epilepsy and Obstructive Sleep Apnea

Positive Airway Pressure Improves Seizure Control in Epilepsy and Obstructive Sleep Apnea

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Treatment with positive airway pressure may help retain or improve seizure control in patients with epilepsy and obstructive sleep apnea.

Early Surgical Intervention Improves Likelihood of Good Cognitive Outcomes in Epilepsy

Early Surgical Intervention Improves Likelihood of Good Cognitive Outcomes in Epilepsy

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Preoperative cognitive function is a central component of predicting cognitive outcomes after resective epilepsy surgery.

Objective Score Identifies Non-Epileptic Psychogenic Seizures Linked to Abuse, TBI

Objective Score Identifies Non-Epileptic Psychogenic Seizures Linked to Abuse, TBI

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This objective score may have the potential to be an early outpatient screening tool for identifying PNES.

Association Between Seizure Onset and Year of Menarche in Women With Epilepsy

Association Between Seizure Onset and Year of Menarche in Women With Epilepsy

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Researchers suggest the combined effects of adrenarche and menarche may play a role in the relationship.

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