Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.
Anup Patel, MD, of Nationwide Children's Hospital and The Ohio State University School of Medicine, discusses findings from a dose-ranging study of cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome. Scroll to below the video for a full text transcript of Dr Patel's interview.
Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.
Cynthia Harden, MD, lead author of the new SUDEP guidelines, discusses the development process and what she hopes clinicians will take away from the guidance. Scroll to below the video for a full text transcript of Dr Harden's interview.
A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.
Sepsis is associated with pathways that lead to permanent neurological sequelae.
In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.
The International League Against Epilepsy has revised its epilepsy classification system in an effort to inform epilepsy research and aid drug development.
Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.
Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.
Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.
Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.
This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.
A diagnosis of maternal epilepsy alone was not associated with an increase in congenital malformations in offspring.
Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.
Functional MRI may provide a less-invasive option for evaluating memory function in patients undergoing epilepsy surgery.
Brain oxygenation may be compromised during periodic discharges, ultimately warranting treatment.
Nearly 60% of patients had achieved seizure freedom at last follow-up, 10 to 21 years after surgery.
Careful monitoring of EEG patterns is a useful way to stratify seizure risk in critically ill patients.
Beate Diehl, MD, PhD, FRCP, discusses her research on post-stroke epilepsy.
Shaun Hussain, MD, MS, discusses a gap in health care provider knowledge that may contribute to the delay in the diagnosis and treatment of infantile spasms.
Elizabeth Thiele, MD, PhD discusses results from her research on cannabidiol in Lennox-Gastaut syndrome.
Clobazam had been previously identified as an AED with a significant interaction with CBD.
Justin Gover, CEO of GW Pharmaceuticals, the parent company of Greenwich Biosciences, discusses the status of the company's cannabidiol product Epidiolex on the heels of positive results from several placebo-controlled trials in epileptic syndromes.
Number of AEDs and seizure frequency also influenced depression in people with epilepsy.
Concordant EEG/fMRI and ESI predicted outcomes with 100% sensitivity and specificity.
Adjunctive everolimus treatment has been found to significantly reduce frequency of treatment-resistant seizures in TSC.
The triple-validated SeLECT score may help identify patients suited for antiepileptic drug trials.
Results of the phase 3, placebo-controlled trial support previous findings from an expanded-access program.
Brain Atrophy May Help Predict Surgical Outcomes in Mesial Temporal Lobe Epilepsy With Hippocampal SclerosisDecember 04, 2016
Atrophy in areas outside of the MTLE-HS network may predict poor surgical outcomes.
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