Seizures

FDA Approves Expanded Seizure Indication for Aptiom

FDA Approves Expanded Seizure Indication for Aptiom

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The FDA has approved an expanded indication for Aptiom to treat pediatric partial-onset seizures.

FDA Approves Briviact for Partial-Onset Seizure Monotherapy

FDA Approves Briviact for Partial-Onset Seizure Monotherapy

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Briviact was initially approved as adjunct treatment for partial-onset seizures.

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

Buccal, Nasal Midazolam Most Cost-Effective for Pediatric Status Epilepticus

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Rectal diazepam is currently the only FDA-approved treatment for pediatric status epilepticus.

Epilepsy Incidence Rates on the Rise in US Adults

Epilepsy Incidence Rates on the Rise in US Adults

Over 1% of the US population reported active or current epilepsy in 2015.

Cannabidiol May Impact Antiepileptic Drug Levels in Refractory Epilepsy

Cannabidiol May Impact Antiepileptic Drug Levels in Refractory Epilepsy

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While several studies have demonstrated efficacy in refractory epilepsy, it is still not clear how cannabidiol may have an impact on current epilepsy treatments.

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone Safe, Tolerable as Adjunctive Therapy in Super-Refractory Status Epilepticus

Brexanolone may help wean patients with super-refractory status epilepticus off of third-line agents.

Review Supports Current NICE Guidelines for Tx of Partial Onset Seizures

Review Supports Current NICE Guidelines for Tx of Partial Onset Seizures

For people with seizures, levetiracetam is more effective than carbamazepine and lamotrigine.

Genetic Testing Justified in Early Childhood Epilepsy

Genetic Testing Justified in Early Childhood Epilepsy

In children with epilepsy, genetic investigation that emphasizes sequencing tests should be part of the initial evaluation.

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

Epilepsy Diagnosis, Outcomes Associated With Depression Severity

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Previous research has found a higher prevalence of depression before and after an epilepsy diagnosis.

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

Vagus Nerve Stimulation Therapy for Epilepsy: FDA Expands Age Range

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The FDA has expanded the age range for the VNS Therapy system.

Partial-Onset Seizure Treatment Discontinued

Partial-Onset Seizure Treatment Discontinued

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Potiga tablets have been discontinued due to the limited use of the medicine.

Case Study: Headache, Confusion, and Seizures in Patient With SLE

Case Study: Headache, Confusion, and Seizures in Patient With SLE

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Woman with SLE complains of headache, confusion, and mild somnolence to the emergency department.

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

Evaluating the Bioequivalence of Generic Lamotrigine for Epilepsy

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The FDA-sponsored study sought to evaluate the bioequivalence of 2 generic forms of the popular epilepsy treatment lamotrigine.

Undetected Seizures May Play a Role in Alzheimer's Pathology

Undetected Seizures May Play a Role in Alzheimer's Pathology

Epileptic phenomena are an important component of the dysfunction of the neuronal networks affected by Alzheimer's disease.

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Effective Dosing of Cannabidiol for Lennox-Gastaut Syndrome

Anup Patel, MD, of Nationwide Children's Hospital and The Ohio State University School of Medicine, discusses findings from a dose-ranging study of cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome. Scroll to below the video for a full text transcript of Dr Patel's interview.

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

Drop Seizure Frequency in Lennox-Gastaut Decreased With Cannabidiol

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Results from 2 phase 3 clinical trials demonstrated efficacy of adjunctive cannabidiol for the treatment of drop seizures in Lennox-Gastaut syndrome.

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Developing and Implementing the New SUDEP Guidelines: An Interview With Cynthia Harden, MD

Cynthia Harden, MD, lead author of the new SUDEP guidelines, discusses the development process and what she hopes clinicians will take away from the guidance. Scroll to below the video for a full text transcript of Dr Harden's interview.

New Guideline Tackles Sudden Unexpected Death in Epilepsy

New Guideline Tackles Sudden Unexpected Death in Epilepsy

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A newly published guideline shines light on sudden unexpected death in epilepsy and how clinicians can help prevent it.

Sepsis Associated With Long-term Seizure Risk

Sepsis Associated With Long-term Seizure Risk

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Sepsis is associated with pathways that lead to permanent neurological sequelae.

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

In Refractory Status Epilepticus, Lacosamide May Be a Good Option

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In patients with lorazepam-resistant status epilepticus, treatment with lacosamide had comparable efficacy and safety as sodium valproate.

International League Against Epilepsy Updates Epilepsy Classification System

International League Against Epilepsy Updates Epilepsy Classification System

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The International League Against Epilepsy has revised its epilepsy classification system in an effort to inform epilepsy research and aid drug development.

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

Aptiom Aims for Pediatric Indication for Partial Onset Seizures

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Sunovion has filed a supplemental NDA with the FDA to expand the indication for Aptiom to pediatric patients with partial onset seizures.

Epilepsy, Seizures Common Among Nursing Home Population

Epilepsy, Seizures Common Among Nursing Home Population

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Elderly patients with neurologic comorbidities such as stroke or dementia had an increased risk for epilepsy or seizures.

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

Unintended Pregnancy in Epilepsy May Be Linked to Contraceptive, AED Combo

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Patients taking enzyme-inducing antiepileptic drugs and hormonal contraceptives face a greater risk of unintended pregnancy.

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

Modified Atkins Diet May Reduce Seizure Frequency in Doose Syndrome

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Participants reported improved adherence to a modified Atkins diet compared with the popular but restrictive ketogenic diet.

Cortical Excitability Tied to Duration and Degree of Seizure Control

Cortical Excitability Tied to Duration and Degree of Seizure Control

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This study identified a feature of the epileptic brain that evolves slowly and differs fundamentally in well-controlled and poorly controlled epilepsy.

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

Maternal Antiepileptic Use and Risk for Major Congenital Malformations in Offspring

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A diagnosis of maternal epilepsy alone was not associated with an increase in congenital malformations in offspring.

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

Epileptic Seizures in Multiple Sclerosis May Suggest Shared Pathology

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Patients with both MS and epileptic seizures had a younger age at onset of MS compared with those without seizures.

Guidelines for Using fMRI for Presurgical Evaluation of Epilepsy

Guidelines for Using fMRI for Presurgical Evaluation of Epilepsy

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Functional MRI may provide a less-invasive option for evaluating memory function in patients undergoing epilepsy surgery.

Should EEG Periodic Discharges be Managed Similarly to Seizures?

Should EEG Periodic Discharges be Managed Similarly to Seizures?

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Brain oxygenation may be compromised during periodic discharges, ultimately warranting treatment.

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