Sleep Disruptions Associated With Increased Amyloid Production

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Sleep deprivation correlated with increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β42 levels.
Sleep deprivation correlated with increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β42 levels.

HealthDay News — Disrupted sleep is associated with increased amyloid-β production in adults, according to a study published online in the Annals of Neurology.

Brendan P. Lucey, MD, from the Washington University School of Medicine in St Louis, and colleagues examined whether sleep disruption increases soluble amyloid-β using indwelling lumbar catheters to serially sample cerebrospinal fluid while 8 participants (aged 30 to 60 years) were sleep-deprived, treated with sodium oxybate, or allowed to sleep normally. Amyloid-β kinetics were measured by infusion with 13C6-leucine.

The researchers found that, compared with controls who were allowed to sleep normally, sleep deprivation correlated with increased overnight amyloid-β-38, amyloid-β-40, and amyloid-β42 levels (25% to 30% increases).

"These findings suggest that disrupted sleep increases Alzheimer disease risk via increased amyloid-β production," the authors write.

Several authors disclosed financial ties to C2N Diagnostics, including receiving royalties for patents and technology.

Reference

Lucey BP, Hicks TJ, McLeland JS, et al. Effect of sleep on overnight CSF amyloid-β kinetics [published online December 8, 2018]. Ann Neurology. doi:10.1002/ana.25117



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