Stroke News Archive

Reperfused Penumbral Volume Predicts Outcomes in Acute Ischemic Stroke

Reperfused Penumbral Volume Predicts Outcomes in Acute Ischemic Stroke

All patients included in the study underwent a MRI or multimodal CT approximately 24 hours after onset of stroke.

Infective Endocarditis: Best Practices for Treating Neurologic Complications

Infective Endocarditis: Best Practices for Treating Neurologic Complications

Ischemic and hemorrhagic strokes are a common complication of infective endocarditis, but guidance on intervention is varied.

Ischemic Stroke Risk Increased With Protein Pump Inhibitor Use

Ischemic Stroke Risk Increased With Protein Pump Inhibitor Use

Long-term, high-dose usage of PPIs increases the risk of first-time ischemic stroke and myocardial infarction.

Similar Bleeding Risk for Direct Oral Anticoagulant vs Warfarin in Venous Thromboembolism

Similar Bleeding Risk for Direct Oral Anticoagulant vs Warfarin in Venous Thromboembolism

Direct oral anticoagulant use is not linked with an increase in major bleeding in patients with VTE.

Key Metrics for Defining Optimal Brain Health in Adults: AHA/ASA Guidance

Key Metrics for Defining Optimal Brain Health in Adults: AHA/ASA Guidance

The American Heart and American Stroke Associations have developed an outline focused on the impact of cognitive impairment on public health, and the maintenance and definition of optimal brain health.

Prevalence of Cardiovascular Risk Factors in Stroke on the Rise

Prevalence of Cardiovascular Risk Factors in Stroke on the Rise

While the increase in cardiovascular risk factors is at least partially due to the obesity epidemic, the researchers believe the increase is multifactorial.

ENCHANTED Update: No Role for Low-Dose Alteplase After All?

ENCHANTED Update: No Role for Low-Dose Alteplase After All?

Results from a secondary analysis of the ENCHANTED trial add to a pile of weak data that likely will not affect clinical practice.

Trial Update: Bariatric Surgery vs Dietary Program for Tx of Idiopathic Intracranial Hypertension

Trial Update: Bariatric Surgery vs Dietary Program for Tx of Idiopathic Intracranial Hypertension

The trial, sponsored by the University of Birmingham, is currently recruiting participants.

Stroke Severity, Collateral Blood Flow Indicate ASPECTS Decay

Stroke Severity, Collateral Blood Flow Indicate ASPECTS Decay

Significant infarct progression can make patients ineligible for mechanical thrombectomy.

Risk Prediction Models for Bleeding Events in Afib Have Modest Success

Risk Prediction Models for Bleeding Events in Afib Have Modest Success

Risk scores help identify high-risk patients who may benefit from intervention.

Atrial Fibrillation Associated With Cognitive Decline

Atrial Fibrillation Associated With Cognitive Decline

Mechanisms including silent cerebral infarct, microemboli, microbleedings, and cerebral hypoperfusion may be responsible for the link between atrial fibrillation and cognitive decline.

After Stroke, High-Intensity Statin Therapy Linked to Fewer Adverse Events

After Stroke, High-Intensity Statin Therapy Linked to Fewer Adverse Events

The findings support the continuation of high-intensity statin therapy after acute ischemic stroke.

High-Risk Stroke Patients With Insulin Resistance Benefit More From Pioglitazone

High-Risk Stroke Patients With Insulin Resistance Benefit More From Pioglitazone

Insulin-resistant patients with ischemic stroke or transient ischemic attack and a high risk of myocardial infarction or recurrent stroke are more likely to derive benefit from pioglitazone than those a lower risk.

Personalized Warfarin Dosing Reduces Risk of Adverse Events

Personalized Warfarin Dosing Reduces Risk of Adverse Events

There is a reduced risk of adverse events associated with genotype-guided warfarin dosing.

Cardiovascular Risk Increases With Discontinuation of Low-Dose Aspirin

Cardiovascular Risk Increases With Discontinuation of Low-Dose Aspirin

For long-term low-dose aspirin users, there is a 30% increased risk of CVD events with discontinuation of aspirin.

Stroke Outcomes Not Improved With Low-Dose Oxygen

Stroke Outcomes Not Improved With Low-Dose Oxygen

Low-dose oxygen use does not reduce death or disability at 3 months among patients with acute stroke.

Thromboembolic Events Most Frequent Mechanism in Postoperative Ischemic Stroke

Thromboembolic Events Most Frequent Mechanism in Postoperative Ischemic Stroke

A better understanding of characteristics of cerebral lesions may help expedite treatment and improve functional outcomes.

Incidence of Seizures and Epilepsy High in Ischemic Stroke

Incidence of Seizures and Epilepsy High in Ischemic Stroke

Newer antiepileptic drugs were associated with fewer adverse effects in patients with ischemic stroke.

Rivaroxaban, Warfarin Show Similar Efficacy in AFib-Related Ischemic Stroke

Rivaroxaban, Warfarin Show Similar Efficacy in AFib-Related Ischemic Stroke

The investigators noted that rivaroxaban was associated with significantly reduced length of hospital stay compared with warfarin.

Intravenous Thrombolysis Plus Mechanical Thrombectomy Improves Stroke Outcomes

Intravenous Thrombolysis Plus Mechanical Thrombectomy Improves Stroke Outcomes

The findings align with current guidelines to administer IV tPA regardless of whether or not a patient with ischemic stroke is set to undergo mechanical thrombectomy.

Early Discharge Services Reduce Hospital Stay, Disability After Stroke

Early Discharge Services Reduce Hospital Stay, Disability After Stroke

Early supported discharge services may also help care facilities better manage their need for hospital beds and conventional hospital stay costs.

Risk of Stroke, Mortality Reduced With High Stem Cell Factor

Risk of Stroke, Mortality Reduced With High Stem Cell Factor

Participants with high baseline levels of SCF had lower all-cause mortality and reduced risk of heart failure, stroke, and myocardial infarction.

Predicting Cerebral Edema Severity After Stroke

Predicting Cerebral Edema Severity After Stroke

There is some evidence that suggests intravenous thrombolysis for stroke may impair the blood-brain barrier and cause cerebral edema.

Ischemic Preconditioning: Exploring the Potential to Reduce the Impact of Stroke

Ischemic Preconditioning: Exploring the Potential to Reduce the Impact of Stroke

Brief periods of oxygen deprivation to the brain have been shown to provide neuroprotective effects that reduce stroke infarct size and improve recovery times.

Noncontrast CT Markers Predict Hematoma Growth Risk in Hemorrhagic Stroke

Noncontrast CT Markers Predict Hematoma Growth Risk in Hemorrhagic Stroke

Surprisingly, no evidence was found to suggest that patients with these markers benefit from intensive blood pressure reduction.

No Benefit of Contact Aspiration Over Stent Retriever in Ischemic Stroke

No Benefit of Contact Aspiration Over Stent Retriever in Ischemic Stroke

The findings may be less applicable to low-volume stroke centers who have less experience in this treatment.

Stroke Risk Increased in Methamphetamine Users

Stroke Risk Increased in Methamphetamine Users

Younger adults who use methamphetamine are at a greater risk for stroke.

Stroke Risk Increased in Patients With Hip Fracture

Stroke Risk Increased in Patients With Hip Fracture

The 30-day cumulative incidences of stroke were 2.16% and 0.21% for patients with hip fracture and the general population.

Unprovoked Venous Thromboembolism May Be Sign of Occult Cancer

Unprovoked Venous Thromboembolism May Be Sign of Occult Cancer

About 1 in 20 patients with VTE have occult cancer detected within a year.

Stroke Risk Not Increased With Radioiodine Therapy for Thyroid Cancer

Stroke Risk Not Increased With Radioiodine Therapy for Thyroid Cancer

There is no increased risk for stroke for people with thyroid cancer who receive radioiodine therapy.

Adult Ischemic Stroke Associated With Higher Childhood BMI

Adult Ischemic Stroke Associated With Higher Childhood BMI

Investigators found a positive association between higher childhood BMI scores and early adult ischemic stroke.

Stroke Risk Increased After Hepatitis C Infection

Stroke Risk Increased After Hepatitis C Infection

Hepatitis C virus (HCV) infection may also increase the risk of stroke.

Stroke Incidence Down in Men

Stroke Incidence Down in Men

The incidence of intracerebral hemorrhage and subarachnoid hemorrhage was stable in both men and women.

THRIVE Score Accurately Predicts Ischemic Stroke Treatment Outcomes

THRIVE Score Accurately Predicts Ischemic Stroke Treatment Outcomes

THRIVE scores not only accurately predicted good and poor outcomes in stroke patients following IVT or ET, but also the degree of ischemia following these treatments.

Expert Analysis: Tenecteplase Yet to Prove Itself vs Alteplase

Expert Analysis: Tenecteplase Yet to Prove Itself vs Alteplase

Despite disappointing results, tenecteplase's story in stroke treatment might not be over.

Poststroke Deficit Recrudescence: Signs and Symptoms to Look For

Poststroke Deficit Recrudescence: Signs and Symptoms to Look For

Women and patients of African-American race face an increased risk of experiencing poststroke recrudescence.

Recurrent Stroke Risk Increased Without Statin Use

Recurrent Stroke Risk Increased Without Statin Use

There is an increased risk of a recurrent stroke after discontinuing statin therapy 3 to 6 months post initial ischemic stroke.

Poor Glycemic Control After Ischemic Stroke Linked to Poor Outcomes

Poor Glycemic Control After Ischemic Stroke Linked to Poor Outcomes

Only 16% of patients had an adequate response to conventional therapy, with patients who didn't considered "non-responders."

Statin Discharge Prescribing Varies in Stroke Belt and Non-Stroke Belt Residents

Statin Discharge Prescribing Varies in Stroke Belt and Non-Stroke Belt Residents

Less than half of individuals with ischemic stroke receive a prescription for statins.

Dementia Risk Significantly Increased for Individuals Born in High Stroke Mortality States

Dementia Risk Significantly Increased for Individuals Born in High Stroke Mortality States

Birthplace is a significant risk factor for dementia, even after adjusting for educational levels, race, and life-course vascular risk factors.

Minimum Headache Duration Prompting Subarachnoid Hemorrhage Workup

Minimum Headache Duration Prompting Subarachnoid Hemorrhage Workup

Subarachnoid hemorrhage must be ruled out in patients with acute onset of severe headache.

Predicting Major Bleeding in Patients With Stroke on Antiplatelets

Predicting Major Bleeding in Patients With Stroke on Antiplatelets

There are a limited number of prediction models that identify patients at risk of major bleeding after stroke or TIA.

Update: Diagnosing Neuropathic Pain in Stroke, MS, Spinal Cord Injury

Update: Diagnosing Neuropathic Pain in Stroke, MS, Spinal Cord Injury

The update focused on diagnosis of neuropathic pain in patients with spinal cord injury, stroke, or multiple sclerosis.

Intravenous Idarucizumab Successfully Reverses Dabigatran

Intravenous Idarucizumab Successfully Reverses Dabigatran

At 90-days, the rate of thrombotic events in both groups was low.

Penumbra Stroke Revascularization Device Recalled

Penumbra Stroke Revascularization Device Recalled

The Penumbra 3D revascularization device was recalled by the FDA because of a risk of the delivery wire breaking during use.

Stroke Prevention Therapy Safe, Effective for Cancer Patients

Stroke Prevention Therapy Safe, Effective for Cancer Patients

Rivaroxaban treatment for nonvalvular AF in patients with cancer is safe.

Even Stable Survivors Face 5-Year Risk of Second Stroke

Even Stable Survivors Face 5-Year Risk of Second Stroke

The risk of a second stroke or transient ischemic attack (TIA) remains considerable for at least 5 years after the first event.

Intensive BP Lowering Does Not Benefit ICH With Spot Sign

Intensive BP Lowering Does Not Benefit ICH With Spot Sign

Although spot sign predicted ICH expansion, it proved to be a less robust diagnostic marker than demonstrated by previous single-center cohort studies.

Weight Gain in Adolescence Linked to Later Stroke Risk

Weight Gain in Adolescence Linked to Later Stroke Risk

An increase in BMI during puberty and adolescence was associated with increase risk of stroke.

Primary Stroke Center Protocol Significantly Improves Outcomes

Primary Stroke Center Protocol Significantly Improves Outcomes

Reduced door-to-needle times have been shown to improve outcomes after stroke.

Cirrhosis Associated With Increased Stroke Risk

Cirrhosis Associated With Increased Stroke Risk

Patients with cirrhosis had a 2.17% per year incidence of stroke compared with 1.11% per year incidence of stroke in patients without cirrhosis.

Long-Term Stroke Outcomes Improved With Nonconventional Therapy

Long-Term Stroke Outcomes Improved With Nonconventional Therapy

Music-and-rhythm therapy has also been shown to help improve balance and memory.

Stroke, Heart Attack Risk Increased With Herpes Zoster

Stroke, Heart Attack Risk Increased With Herpes Zoster

Clinicians should make patients aware of their increased risk for stroke and heart attack.

Higher Risk for Symptomatic Intracranial Hemorrhage After Endovascular Treatment for Stroke

Higher Risk for Symptomatic Intracranial Hemorrhage After Endovascular Treatment for Stroke

Risk for symptomatic intracranial hemorrhage after endovascular treatment for acute ischemic stroke is significantly higher in real-world practice than rates reported by clinical trials.

Head Position in Stroke: Does It Matter?

Head Position in Stroke: Does It Matter?

Positioning of the head in acute ischemic stroke does not seem to affect recovery.

Stroke and Dementia Associated with Artificially-Sweetened Drinks?

Stroke and Dementia Associated with Artificially-Sweetened Drinks?

According to a study published in Stroke artificially-sweetened beverages is associated with increased risk of stroke and dementia.

Intracranial Hemorrhage Associated with Arteriovenous Malformations Linked to Better Outcomes

Intracranial Hemorrhage Associated with Arteriovenous Malformations Linked to Better Outcomes

Compared with other sources of ICH, those associated with arteriovenous malformations had lower odds of death.

Migraine-Associated Stroke Not Linked to Atherosclerosis

Migraine-Associated Stroke Not Linked to Atherosclerosis

Intracranial atherosclerosis was lower in patients with migraine compared with those without migraine.

Reduced Stroke Risk With Vitamin K Antagonist Monotherapy

Reduced Stroke Risk With Vitamin K Antagonist Monotherapy

Dual therapy was associated with a significantly higher bleeding risk.

Stroke Prevention May Help Reduce Dementia Risk

Stroke Prevention May Help Reduce Dementia Risk

Delays in anticoagulation treatment resulted in increased risk for dementia.

Mechanical Thrombectomy Safe in Older Stroke Patients

Mechanical Thrombectomy Safe in Older Stroke Patients

No between-group differences were observed for reperfusion success and mortality, among other measures.

After Stroke Onset, Prehospital ECG Helps Detect Atrial Fibrillation

After Stroke Onset, Prehospital ECG Helps Detect Atrial Fibrillation

Neglecting abnormalities in ECG readings could result in serious acute cardiac events in patients presenting with stroke.

After Stroke, Intensive Antiplatelet Therapy Has Benefits, Drawbacks

After Stroke, Intensive Antiplatelet Therapy Has Benefits, Drawbacks

Intensive antiplatelet therapy appears to reduce risk of recurrence immediately after stroke, but may pose risks further out.

Stroke Awareness: Do Your Patients Know the Signs?

Stroke Awareness: Do Your Patients Know the Signs?

New research from the American Heart and American Stroke Associations found that many Americans don't know the symptoms of stroke.

Stroke Prevention Strategies May Help Prevent Dementia

Stroke Prevention Strategies May Help Prevent Dementia

Findings from a new study suggest that engaging in stroke prevention strategies may help reduce the risk of dementia.

In Hypogonadism, Stroke May Be Prevented With Testosterone Replacement Therapy

In Hypogonadism, Stroke May Be Prevented With Testosterone Replacement Therapy

Men who received testosterone replacement therapy had lower odds of cardiovascular events.

In Endovascular Therapy for Stroke, Monitored Anesthesia Is Safe, Effective

In Endovascular Therapy for Stroke, Monitored Anesthesia Is Safe, Effective

Monitored anesthesia was found to be as safe and effective as general anesthesia in patients undergoing endovascular therapy for stroke.

Using E-Management to Improve Oral Anticoagulation Tx

Using E-Management to Improve Oral Anticoagulation Tx

E-health-based coagulation service was linked to lower frequency of adverse events, including thromboembolism, bleeding, and death.

Ischemic Stroke Risk Elevated in Systemic Lupus Erythematosus

Ischemic Stroke Risk Elevated in Systemic Lupus Erythematosus

The relative risk of developing ischemic stroke was increased in patients with systemic lupus erythematosus, especially within the first year after diagnosis.

Improving Stroke Diagnosis Accuracy: An Interview With David Newman-Toker, MD, PhD

Improving Stroke Diagnosis Accuracy: An Interview With David Newman-Toker, MD, PhD

Neurologists need to engage their emergency medicine colleagues to identify protocols and pathways for when to trigger appropriate neurological consultation or initiate acute stroke therapies.

Prevalence of Ischemic Stroke Increasing in Young Adults

Prevalence of Ischemic Stroke Increasing in Young Adults

During the study period, the percentage of people with 3 or more stroke risk factors roughly doubled for all age groups.

Stroke Risk and Serum Uric Acid Levels: Does Gender Play a Role?

Stroke Risk and Serum Uric Acid Levels: Does Gender Play a Role?

Previous studies have produced contradictory evidence of a link between serum UA and stroke risk, with some pointing to greater risks in women compared with men.

Endovascular Stroke Treatment Shows Sustained Response Up to 2 Years

Endovascular Stroke Treatment Shows Sustained Response Up to 2 Years

Over 32% of patients were functionally independent at 90 days and 37.1% were functionally independent at 2 years.

Telestroke Treatment With IV tPA: How Long Is the Window of Opportunity?

Telestroke Treatment With IV tPA: How Long Is the Window of Opportunity?

There is little data to support telestroke for IV thrombolysis administration in the extended time window of 3 to 4.5 hours after stroke onset.

In Ischemic Stroke, Pulse Pressure Predicts Long-Term Risk of Recurrence

In Ischemic Stroke, Pulse Pressure Predicts Long-Term Risk of Recurrence

Pulse pressure was associated with the risk for ischemic stroke in first-ever ischemic stroke patients old than 60 years.

Intracerebral Hemorrhage Outcomes Improved With Anticoagulants

Intracerebral Hemorrhage Outcomes Improved With Anticoagulants

Resumption of oral anticoagulants after intracerebral hemorrhage was found to improve outcomes at 1 year.

Stroke During, After Pregnancy Linked to Preeclampsia

Stroke During, After Pregnancy Linked to Preeclampsia

Mortality among women with preeclampsia and pregnancy-associated stroke was significantly higher than in controls.

IV tPA Effective for Stroke in Patients With Increased Body Weight

IV tPA Effective for Stroke in Patients With Increased Body Weight

Previous research had suggested that the benefits of IV tPA are diminished in patients weighing more than 100 kg.

Hyperglycemia Impacts Functional Outcomes After Endovascular Thrombectomy

Hyperglycemia Impacts Functional Outcomes After Endovascular Thrombectomy

Higher glucose levels reduce likelihood of good outcome among stroke patients with good collaterals.

Is tPA Safe for Sickle Cell Patients in Acute Ischemic Stroke?

Is tPA Safe for Sickle Cell Patients in Acute Ischemic Stroke?

Having sickle cell disease did not adversely affect any of the indicators the researchers measured.

Intracranial Bleed Risk Compared for Warfarin, Apixaban in Afib Patients

Intracranial Bleed Risk Compared for Warfarin, Apixaban in Afib Patients

Patients taking apixaban showed significantly less intracranial hemorrhage (0.33% per year) vs patients taking warfarin (0.80% per year), no matter the type and location.

Pre-Stroke Exercise, Not BMI, Predicts Stroke Outcomes

Pre-Stroke Exercise, Not BMI, Predicts Stroke Outcomes

Patients who exercised prior to their stroke were more likely to be able to perform basic and complex tasks after the stroke event.

In Intracerebral Hemorrhage, Intensive BP Lowering Has Little Impact on Outcomes

In Intracerebral Hemorrhage, Intensive BP Lowering Has Little Impact on Outcomes

The investigators reported no difference in 3-month mortality rates across all 5 studies included in the meta-analysis.

Mobile Stroke Unit Tied to Decreased Time to Imaging, Treatment

Mobile Stroke Unit Tied to Decreased Time to Imaging, Treatment

Use of mobile stroke units is associated with reduced time to imaging and thrombolysis compared with traditional care.

After Acute Stroke, No Rush to Continue Antihypertensive Therapy

After Acute Stroke, No Rush to Continue Antihypertensive Therapy

There is no urgency to administer preexisting antihypertensive therapy in the first few hours or days after stroke, unless indicated for other comorbid conditions.

Link Between Stroke Severity, Anticoagulation in Atrial Fibrillation

Link Between Stroke Severity, Anticoagulation in Atrial Fibrillation

A substantial number of strokes may be due to underuse of or inadequate anticoagulation in Afib.

Hyperglycemia Linked to Infection, Worse Outcomes After Stroke

Hyperglycemia Linked to Infection, Worse Outcomes After Stroke

Admission hyperglycemia was associated with poststroke infection, as well as 3-month functional outcome and mortality.

Long-Term Thrombolytic Tx Does Not Benefit Intermediate-Risk PE

Long-Term Thrombolytic Tx Does Not Benefit Intermediate-Risk PE

Results at 3 years for tenecteplase vs placebo in patients with intermediate-risk pulmonary embolism.

VTE Recurrence Decreased With Rivaroxaban

VTE Recurrence Decreased With Rivaroxaban

Recurrent fatal or nonfatal VTE occurred in 1.5% of patients who took 20 mg of rivaroxaban, 1.2% of patients who took 10 mg, and 4.4% who took aspirin.

Patent Foramen Ovale Closure Reduces Stroke Risk in Patients With Inherited Thrombophilias

Patent Foramen Ovale Closure Reduces Stroke Risk in Patients With Inherited Thrombophilias

Patients with inherited thrombophilias who did not undergo patent foramen ovale closure faced a significantly increased risk of stroke.

Many A-Fib Patients Not Getting Appropriate Anticoagulation Therapy

Many A-Fib Patients Not Getting Appropriate Anticoagulation Therapy

More than 80% of ischemic stroke patients weren't getting adequate anticoagulation therapy.

Migraine Linked to Ischemic Stroke Via Cervical Artery Dissection

Migraine Linked to Ischemic Stroke Via Cervical Artery Dissection

Up to 20% of stroke cases in young adults occur in those with cervical artery dissection, the leading cause of stroke in this population.

Prestroke CHA2DS2-VASc Score Predicts Stroke Severity, Outcomes

Prestroke CHA2DS2-VASc Score Predicts Stroke Severity, Outcomes

Clinicians should closely monitor patients with atrial fibrillation, especially if they are female and of increasing age.

Intensive Antiplatelet Therapy and Risk of Recurrent Stroke

Intensive Antiplatelet Therapy and Risk of Recurrent Stroke

Efficacy of triple antiplatelet therapy compared with current guideline-based therapy for the prevention of recurrent stroke was evaluated in the TARDIS trial.

Increased Use of Antithrombotics Driving Subdural Hematoma Prevalence

Increased Use of Antithrombotics Driving Subdural Hematoma Prevalence

The increase in usage of antithrombotics, especially vitamin K antagonists, has been linked to an increase in prevalence of subdural hematomas.

Vagus Nerve Stimulation May Improve Stroke Recovery

Vagus Nerve Stimulation May Improve Stroke Recovery

More patients receiving VNS experienced enhanced arm movement over a 90-day period.

Oral Anticoagulation After ICH: Risks and Outcomes

Oral Anticoagulation After ICH: Risks and Outcomes

Restarting anticoagulation after both nonlobar and lobar ICH was associated with decreased mortality.

Is There Gender Bias in Stroke Care?

Is There Gender Bias in Stroke Care?

Men were more likely than women to be treated with IV tPA within 30 minutes of arrival at a hospital.

Medical Complications After ICH: Changes in the Last Decade

Medical Complications After ICH: Changes in the Last Decade

As more patients survive ICH, emphasis is slowly shifting from survival to improving ICH-related morbidity and optimization of functional recovery.

Contact Aspiration vs Stent Retriever in Acute Ischemic Stroke

Contact Aspiration vs Stent Retriever in Acute Ischemic Stroke

The results provide good evidence for the use of contact aspiration in ischemic stroke.

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