Whether major depressive disorder is a comorbidity of bipolar disorder isn’t really known. Researchers built a predictive model of major depressive disorder to bipolar disorder conversion and with the Observational Medical Outcomes Partnership validated the results across a multi-national network of patient databases.
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Registries databases were searched for randomized controlled trials published between 1952 and 2020 that evaluated psychological interventions for adults diagnosed with bipolar I or bipolar II disorder.