In a global, phase 3 trial, researchers evaluated the efficacy of ganaxolone as an adjunctive treatment compared to placebo for major motor seizures in patients with CDKL5 deficiency disorder.
Investigators conducted a survey to assess the incidence of COVID-19 in patients with multiple sclerosis as well as the influence of their comorbidities and treatments on outcomes.
Proinflammatory cytokines, tryptophan catabolites, and the gut-brain axis may have key roles in chronic fatigue and depression in patients with multiple sclerosis.
Study findings present 71% of patients with new-onset super refractory status epilepticus as having good or fair outcomes at long-term follow-up.
Increases in multiple neurologic factors likely led the increase in United States epilepsy-related mortality rates between 1999 and 2017.
In early Parkinson Disease, fatigue, excessive daytime sleepiness, and emotional apathy are predictive of increasing fatigue severity.
Depression has been linked to elevated markers of inflammation, and aspirin, a nonsteroid, anti-inflammatory medication, can irreversibly inhibit cyclooxygenase-1 and 2.
Children who receive a depression diagnosis in their primary school age have a substantially higher risk of a depression relapse during adolescence compared with children who did not receive a depression diagnosis during their primary school age.
Convergent abnormalities were observed in secondary analyses across portions of the amygdala, hippocampus, subgenual cingulate cortex, and putamen.
Neurobehavioral Disorders, Sleep Disorders
Researchers examined how the associations of life event stress with impulsivity, anxiety, and depressed mood change in the presence of sleep disturbance.