Neurocognitive Disorders
Sleep abnormalities and cognition in bipolar disorder may be related, and may affect cognition in this patient population.
Neurobehavioral Disorders
The approval was based on the ASPIRE I and II trials that compared the efficacy and safety of esketamine, an N-methyl-D-aspartate receptor antagonist, to placebo in 449 adults with moderate to severe MDD who had active suicidal ideation and intent.
Neurobehavioral Disorders
Polygenic risk scores predict the progression from unipolar depression to bipolar or psychiatric disorders.
Neurobehavioral Disorders
Depression has been linked to elevated markers of inflammation, and aspirin, a nonsteroid, anti-inflammatory medication, can irreversibly inhibit cyclooxygenase-1 and 2.
Neurobehavioral Disorders
Children who receive a depression diagnosis in their primary school age have a substantially higher risk of a depression relapse during adolescence compared with children who did not receive a depression diagnosis during their primary school age.
Neurobehavioral Disorders, Sleep Disorders
Heightened cognitive arousal at bedtime is linked to objective sleep disturbances and indicators of psychological hyperarousal at night and during the day.
Neurobehavioral Disorders
Convergent abnormalities were observed in secondary analyses across portions of the amygdala, hippocampus, subgenual cingulate cortex, and putamen.
Neurocognitive Disorders
While the relationship between current mood state and cognitive impairment is unclear, more severe depression has been linked to greater impairment.
Sleep Disorders
Among adults without a clinical diagnosis of ADHD, heavy alcohol use predicted more severe ADHD symptoms.
Pediatric Neurology
The researchers concluded that the correlation between interregional cortical thinning during maturation and expression patterns of genes associated with multiple psychiatric disorders suggested a common molecular process.