Whether major depressive disorder is a comorbidity of bipolar disorder isn’t really known. Researchers built a predictive model of major depressive disorder to bipolar disorder conversion and with the Observational Medical Outcomes Partnership validated the results across a multi-national network of patient databases.
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The researchers analyzed data from a large randomized noninferiority trial that compared theta-burst stimulation and high-frequency (10 Hz) rTMS delivered to the left dorsolateral prefrontal cortex.
Researchers compared how patients experiencing a major depressive episode and control participants perceived contrast patterns.
Registries databases were searched for randomized controlled trials published between 1952 and 2020 that evaluated psychological interventions for adults diagnosed with bipolar I or bipolar II disorder.