This study highlights the importance of transdiagnostic approaches to psychiatry.
Polygenic risk scores predict the progression from unipolar depression to bipolar or psychiatric disorders.
While the relationship between current mood state and cognitive impairment is unclear, more severe depression has been linked to greater impairment.
Overall, in all patients with MDD, sleep ultradian cycle number was positively associated with REMS percentage, REMS duration, and REMS/NREMS ratio and negatively associated with REM latency.
The study provides strong evidence for the utility of resting-state fMRI measures in predicting the development of attentional or mood disorders in children.