Polygenic risk scores predict the progression from unipolar depression to bipolar or psychiatric disorders.
Depression has been linked to elevated markers of inflammation, and aspirin, a nonsteroid, anti-inflammatory medication, can irreversibly inhibit cyclooxygenase-1 and 2.
Children who receive a depression diagnosis in their primary school age have a substantially higher risk of a depression relapse during adolescence compared with children who did not receive a depression diagnosis during their primary school age.
Neurobehavioral Disorders, Sleep Disorders
Heightened cognitive arousal at bedtime is linked to objective sleep disturbances and indicators of psychological hyperarousal at night and during the day.
Convergent abnormalities were observed in secondary analyses across portions of the amygdala, hippocampus, subgenual cingulate cortex, and putamen.
While the relationship between current mood state and cognitive impairment is unclear, more severe depression has been linked to greater impairment.
Among adults without a clinical diagnosis of ADHD, heavy alcohol use predicted more severe ADHD symptoms.
Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is a disorder characterized by marked fatigue, exertion induced malaise, cognitive clouding (or brain fog), impaired academic/work performance, disrupted sleep, and joint/muscle pain.
The researchers concluded that the correlation between interregional cortical thinning during maturation and expression patterns of genes associated with multiple psychiatric disorders suggested a common molecular process.
Alzheimer's Disease and Dementia
The FDA has granted Breakthrough Therapy designation to AXS-05 (Axsome Therapeutics) for the treatment of Alzheimer disease agitation.