AAN 2018

Neuromodulation Therapy Gives Relief From Hand Tremor

Neuromodulation Therapy Gives Relief From Hand Tremor

Non-invasive neuromodulation therapy using a custom stimulation pattern provides symptomatic relief from hand tremor in essential tremor.

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

Predictors of Conversion to Neurodegenerative Disease in REM Sleep Behavior Disorder

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Several prodromal symptoms in REM sleep behavior disorder are highly associated with conversion to neurodegenerative diseases.

Efficacy of Disease-Modifying Drugs for Multiple Sclerosis May Decrease With Age

Efficacy of Disease-Modifying Drugs for Multiple Sclerosis May Decrease With Age

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A regression model showed that efficacy of DMTs significantly decreased until age 53, after which disease progression is not affected by DMTs.

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

Wearable Sensors May Help Predict On, Off States in Parkinson Disease

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Wearable technology may help monitor on/off states in patients with Parkinson disease in an outpatient setting.

Pain, Psychiatric Comorbidities More Common in Chronic vs Episodic Migraine

Pain, Psychiatric Comorbidities More Common in Chronic vs Episodic Migraine

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Individuals with chronic vs episodic migraine may be more likely to experience chronic back pain, chronic pain, neck pain, anxiety, and depression.

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

Treatment-Emergent Adverse Events With Adjunctive Eslicarbazepine Acetate in Pediatric Epilepsy

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Researchers evaluated the incidence of treatment-emergent adverse events in pediatric patients taking eslicarbazepine acetate with other antiepileptic drugs to better understand tolerability profiles.

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

DBS Improves Inpatient Outcomes for Comorbid Parkinson Disease and Depression

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Researchers sought to assess outcomes in hospitalized patients with comorbid Parkinson disease and major depressive disorder following administration of deep brain stimulation.

New Zolmitriptan Intracutaneous System Safe and Effective for Migraine

New Zolmitriptan Intracutaneous System Safe and Effective for Migraine

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Researchers conducted a randomized, double-blond, placebo-controlled, dose-ranging trial to assess the use of a new zolmitriptan intracutaneous delivery system in adults with migraine headache.

Erenumab Shown to Reduce Headache Days for Patients with Episodic Migraine

Erenumab Shown to Reduce Headache Days for Patients with Episodic Migraine

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Researchers assessed the ability of erenumab to decrease the mean number of acute headache days in patients with episodic migraine.

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

Adjunctive Eslicarbazepine Safe and Well Tolerated for Pediatric Seizures

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Researchers conducted post-hoc analysis of data derived from 2 randomized, placebo-controlled trials to determine the safety and tolerability of eslicarbazepine in pediatric patients with partial-onset seizures not responsive to treatment with ≤2 antiepileptic drugs.

Predicting Stroke Subtype Risk With Retinal Microvascular Abnormalities

Predicting Stroke Subtype Risk With Retinal Microvascular Abnormalities

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The results suggest a noninvasive method for predicting individualized risk for certain stroke subtypes.

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

Solriamfetol Associated With Improvement in Narcolepsy Types 1 and 2

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Patients in the 2 highest dosing groups saw significant, sustained improvements over the 12-week study.

Comorbidity More Likely With Chronic Migraine vs Episodic Migraine

Comorbidity More Likely With Chronic Migraine vs Episodic Migraine

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Researchers deployed a survey to determine the extent of pain, psychiatric, endocrine, and neurologic comorbidities in patients with chronic or episodic migraine.

Ozanimod Superior to Interferon β-1a for Treatment of Relapsing Multiple Sclerosis

Ozanimod Superior to Interferon β-1a for Treatment of Relapsing Multiple Sclerosis

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Researchers sought to compare the safety and efficacy of ozanimod vs interferon β-1a in individuals with relapsing multiple sclerosis.

MIND Diet Linked to Slower Cognitive Decline Among Stroke Survivors

MIND Diet Linked to Slower Cognitive Decline Among Stroke Survivors

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The MIND diet, a combination of the Mediterranean and DASH diets, was associated with a slower rate of cognitive decline among stroke survivors.

Micronutrient Levels May Be Altered in ADHD

Micronutrient Levels May Be Altered in ADHD

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Levels of magnesium, folate, vitamin B12, zinc, and vitamin D 25-OH were significantly altered in children with ADHD.

Eptinezumab for Frequent Episodic Migraine: Results of Phase 3 PROMISE-1 Study

Eptinezumab for Frequent Episodic Migraine: Results of Phase 3 PROMISE-1 Study

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Eptinezumab, a humanized monoclonal antibody specific to calcitonin gene-related peptide, may be an effective prophylactic for individuals with frequent episodic migraines.

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

Multiple Sclerosis Guidelines: AAN's Recommendations for Initiating, Switching, Stopping Disease-Modifying Therapy

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The new guidelines focus on helping clinicians decide when to initiate, switch, or discontinue disease-modifying therapies for multiple sclerosis.

Cardiovascular Comorbidities Linked to Increased Brain Atrophy in Multiple Sclerosis

Cardiovascular Comorbidities Linked to Increased Brain Atrophy in Multiple Sclerosis

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Researchers investigated the association between cardiovascular risk factors and the development of brain atrophy in individuals with multiple sclerosis.

Are Vaccines Associated With Multiple Sclerosis Relapse?

Are Vaccines Associated With Multiple Sclerosis Relapse?

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Researchers found there are no associations between vaccinations and multiple sclerosis relapse flares.

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

Seizure-Free Status Prior to Conception Lowers Odds of Recurrence During Pregnancy

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Prior studies have suggested that women with epilepsy who are seizure free ≥9 months prior to pregnancy have a high likelihood of remaining seizure free during pregnancy.

Novel Therapy May Improve Symptoms in Early Huntington Disease

Novel Therapy May Improve Symptoms in Early Huntington Disease

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Researchers found that high doses of the novel antisense oligonucleotide were associated with lower concentrations of mutant huntingtin protein in the cerebrospinal fluid and brain.

Blood Pressure-Dementia Link May Be Affected by Population Characteristics

Blood Pressure-Dementia Link May Be Affected by Population Characteristics

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Meta-analyses were conducted to assess the relationship between blood pressure and dementia in an aging population.

Switching to Oral Fingolimod From Injectable Treatment Linked to Fewer MS Relapses

Switching to Oral Fingolimod From Injectable Treatment Linked to Fewer MS Relapses

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As injectable disease-modifying therapies can be inconvenient for patients with MS, fingolimod offers an oral treatment option that is associated with significantly lower risk for relapse.

Interaction of Alcohol, Smoking on Multiple Sclerosis Severity

Interaction of Alcohol, Smoking on Multiple Sclerosis Severity

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A cross-sectional study aimed to assess the effect of smoking and alcohol consumption along with the interactions they have on the clinical course of multiple sclerosis.

Serotonin Reuptake Inhibitors May Improve OSA in Depression With and Without Epilepsy

Serotonin Reuptake Inhibitors May Improve OSA in Depression With and Without Epilepsy

Research was conducted to identify an association between the use of serotonin reuptake inhibitors and obstructive sleep apnea in a population of individuals with depression with or without epilepsy.

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Alpha-Synuclein Levels in Tears May Help ID Parkinson's

Researchers say that tears may be an inexpensive, reliable, and noninvasive biological marker of Parkinson's disease.

AAN: Adherence to DASH Diet May Reduce Risk of Depression

AAN: Adherence to DASH Diet May Reduce Risk of Depression

Using a validated food frequency questionnaire, diet scores were computed for the DASH diet, Mediterranean diet, Mediterranean-DASH Intervention for Neurodegenerative Delay diet, prudent, and Western diets.

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

AAN: Gluten-Free Diet May Help Cut Pain in Gluten Neuropathy

For patients with gluten neuropathy, following a strict gluten-free diet is associated with significantly reduced odds of peripheral neuropathic pain.

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