AES 2015

Aptiom Monotherapy May Improve Quality of Life in Epilepsy

Aptiom Monotherapy May Improve Quality of Life in Epilepsy

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Visits to the emergency department were also reduced.

Real-Time Seizure Detection Possible with Learning Algorithm

Real-Time Seizure Detection Possible with Learning Algorithm

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Continuous analysis of EEG output helps the algorithm adapt to changes in brain activity.

Intractable Epilepsy Advances Brain Aging

Intractable Epilepsy Advances Brain Aging

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Structural MRI revealed differences in white matter in people with intractable epilepsy compared to healthy controls.

Cannabidiol Effective for Reducing Seizures in Treatment-Resistant Epilepsy

Cannabidiol Effective for Reducing Seizures in Treatment-Resistant Epilepsy

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A large, multi-center study found cannabidiol effective for the reduction of seizures

Novel Seizure Detection Device as Sensitive as Video EEG Review

Novel Seizure Detection Device as Sensitive as Video EEG Review

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The Brain Sentinel device was as sensitive as vEEG review by an epileptologist for seizure detection.

Gene Mutations Associated with Sudden Cardiac Death Linked to SUDEP

Gene Mutations Associated with Sudden Cardiac Death Linked to SUDEP

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Cardiac dysrhythmia may contribute to pathophysiology in a proportion of SUDEP cases.

Three Biosignals More Accurately Detect Seizures Than Heart Rate Alone

Three Biosignals More Accurately Detect Seizures Than Heart Rate Alone

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Heart rate, arterial oxygenation, and electrodermal activity improved accuracy compared with heart rate alone.

Circadian Genes May Impact Pathogenesis of Pediatric Focal Epilepsy

Circadian Genes May Impact Pathogenesis of Pediatric Focal Epilepsy

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These functional analyses suggest that the circadian pathway may be a promising target for therapeutic intervention.

Genetic Mutation Identification Expands Epilepsy Phenotypes

Genetic Mutation Identification Expands Epilepsy Phenotypes

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Mutations were identified in 7 genes, including one for the first time.

Integration of Mental Health Screening May Prevent Suicide in Epilepsy

Integration of Mental Health Screening May Prevent Suicide in Epilepsy

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Incorporating mental health screenings in epilepsy appointments may help prevent suicides.

Whole Exome Sequencing Effective for Epilepsy Diagnosis in Children

Whole Exome Sequencing Effective for Epilepsy Diagnosis in Children

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WES identified a definite/likely diagnosis in 32% of patients and a possible diagnosis in 22% of patients, for an overall yield of 54%.

Brief Assessment Identifies Cognitive Issues in Children with Epilepsy

Brief Assessment Identifies Cognitive Issues in Children with Epilepsy

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The 30-minute assessment may help identify those at highest risk of cognitive problems.

Temporal Lobe Epilepsy Via Hippocampal Sclerosis Affects Memory Function

Temporal Lobe Epilepsy Via Hippocampal Sclerosis Affects Memory Function

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Impairment in recalling names, routes, stories, messages, and a space/time disorientation can adversely impact social adaptation.

Seizures Affect Long-Term Memory in Animal Study

Seizures Affect Long-Term Memory in Animal Study

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Inhibiting the pathway upstream of mTOR at the level of PI3K signaling, a locus of significant molecular crosstalk in this pathway, restored the seizure-induced learning and memory deficits.

White Matter Abnormalities Linked to Cognitive Ability in Epilepsy

White Matter Abnormalities Linked to Cognitive Ability in Epilepsy

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White matter integrity plays an important part in the neural signature of cognitive impairment in early onset epilepsy.

Simultaneous fMRI, Direct Electrical Stimulation Feasible in Epilepsy

Simultaneous fMRI, Direct Electrical Stimulation Feasible in Epilepsy

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fMRI-DES could be used for full-brain volume evaluation of brain connectivity and help lead to the refinement of laser ablative procedures for epilepsy.

What to Expect at the 2015 American Epilepsy Society Annual Meeting

What to Expect at the 2015 American Epilepsy Society Annual Meeting

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Ruben Kuzniecky, MD, outlines what to expect at this year's American Epilepsy Society Annual Meeting.

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