ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ALKERAN FOR INJECTION
Leukemias, lymphomas, and other hematologic cancers
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ALKERAN FOR INJECTION Rx

Generic Name and Formulations:
Melphalan HCl 50mg/vial; pwd for IV infusion after reconstitution and dilution.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for ALKERAN FOR INJECTION:

Palliative treatment of multiple myeloma when oral therapy is not appropriate.

Adult:

Give by IV infusion over 15–20 minutes. 16mg/m2 every 2 weeks for a total of 4 doses, then at 4-week intervals. Continue treatment as hematological recovery permits. Renal insufficiency (BUN≥30mg/dL): consider reducing dose by 50%.

Children:

Not recommended.

Contraindications:

Prior resistance to melphalan.

Boxed Warning:

Should be administered under the supervision of an experienced physician in cancer chemotherapeutic agents. May cause severe bone marrow suppression with resulting infection or bleeding. Intravenous (IV) form may be more myelosuppressive than oral form. Leukemogenic in humans. Potentially mutagenic.

Warnings/Precautions:

Prior irradiation or chemotherapy. Bone marrow suppression. Azotemia. Monitor platelets, hemoglobin, WBC and differential at start of therapy and prior to each course; discontinue if WBC <3,000cells/µL or platelets <100,000cells/µL. Moderate to severe renal impairment. Elderly. Pregnancy (Cat.D), nursing mothers: not recommended.

See Also:

ALKERAN

Pharmacological Class:

Alkylating agent.

Interactions:

Radiotherapy potentiates antineoplastic effect. For IV: caution with cyclosporine, cisplatin, BCNU, nalidixic acid.

Adverse Reactions:

Bone marrow suppression, GI upset, hepatic dysfunction, anemia, blood dyscrasias, secondary malignancies (eg, nonlymphocytic leukemia), rash, alopecia, pulmonary fibrosis, interstitial pneumonitis, gonadal toxicity (amenorrhea, infertility); hypersensitivity reactions, cardiac arrest (rare).

How Supplied:

Tabs—50; single-use vial—1 (w. diluent)

Sign Up for Free e-newsletters



CME Focus