Amyotrophic Lateral Sclerosis (ALS)

Predicting ALS Disease Progression With Respiratory Function Decline

Predicting ALS Disease Progression With Respiratory Function Decline

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Patients older than 65 were more likely to have steeper declines in slow vital capacity.

Neuropsychiatric Conditions Common in Relatives of Patients With Amyotrophic Lateral Sclerosis

Neuropsychiatric Conditions Common in Relatives of Patients With Amyotrophic Lateral Sclerosis

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Repeat expansion of the C9orf72 gene does not account for the elevated prevalence of neuropsychiatric disease in relatives of patients with amyotrophic lateral sclerosis.

Amyotrophic Lateral Sclerosis Progression Associated With Changes in Immune Status

Amyotrophic Lateral Sclerosis Progression Associated With Changes in Immune Status

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The findings suggest that changes in immune status may be a consequence of ALS.

ALS Risk Reduced With Exposure to Exogenous Hormones

ALS Risk Reduced With Exposure to Exogenous Hormones

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Results suggest that sex hormones may play a role in the development of amyotrophic lateral sclerosis.

New Amyotrophic Lateral Sclerosis Tx Available

New Amyotrophic Lateral Sclerosis Tx Available

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Radicava is the first FDA approved treatment for ALS in over 20 years.

Parkinson's, ALS Risk Increased in White-Collar Workers

Parkinson's, ALS Risk Increased in White-Collar Workers

There is a higher risk of death from Parkinson's disease or ALS in white collar workers.

VIDEO: Implanted Brain-Computer Interface Allows ALS Patient to Communicate

VIDEO: Implanted Brain-Computer Interface Allows ALS Patient to Communicate

Signals sent to the hand emerge as a typed message on a tablet computer, according to the report.

A Good Diet Translates into Better Functionality in ALS

A Good Diet Translates into Better Functionality in ALS

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The foods most negatively correlated with ALSFRS-R score were milk, lunchmeats, and beef and pork.

Antiretroviral Therapy for HIV-Associated ALS

Antiretroviral Therapy for HIV-Associated ALS

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The results indicate HERV-K activation as a potential mechanism for HIV-associated ALS.

Discovery of New ALS Gene Attributed to Funding From Ice Bucket Challenge

Discovery of New ALS Gene Attributed to Funding From Ice Bucket Challenge

The study was an international effort that sequenced the genomes of at least 15,000 individuals with ALS.

Stem Cell Transplant Feasible in ALS

Stem Cell Transplant Feasible in ALS

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The study was to examine the safety of the procedure.

Environmental Pollutants May Contribute to ALS Risk

Environmental Pollutants May Contribute to ALS Risk

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Researchers believe that the findings may present an opportunity to modify risk.

Depression Affects Quality of Life, Mortality in ALS

Depression Affects Quality of Life, Mortality in ALS

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Depression of some degree is prevalent in a majority of patients with ALS.

Analysis of WHI Data Links Strenuous Exercise to ALS

Analysis of WHI Data Links Strenuous Exercise to ALS

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Data from the Women's Health Initiative suggest a relationship between strenuous exercise and amyotrophic lateral sclerosis.

Boosting Proteasome Function May Prevent Spread of Tau Protein

Boosting Proteasome Function May Prevent Spread of Tau Protein

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Addressing proteasome dysfunction may help prevent accumulation of the toxic protein.

Mesenchymal Neurotrophic Growth Factor Cells May Slow ALS

Mesenchymal Neurotrophic Growth Factor Cells May Slow ALS

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Results indicate that IT and IM administration of MSC-NTF cells is safe in patients with ALS and may ultimately provide clinical benefit.

Nuclear Transport Disruption Linked to Amyotrophic Lateral Sclerosis

Nuclear Transport Disruption Linked to Amyotrophic Lateral Sclerosis

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A gene mutation behind a large amount of ALS and FTD cases may disrupt nuclear transport, destroying neurons.

Ancient Viral Genes May Activate in Amyotrophic Lateral Sclerosis

Ancient Viral Genes May Activate in Amyotrophic Lateral Sclerosis

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Researchers are now testing whether antiretroviral drugs used to treat HIV/AIDS are effective in ALS patients.

Low BMI, High Dietary Intake Linked to ALS

Low BMI, High Dietary Intake Linked to ALS

A high fat diet, but low BMI suggest an altered energy metabolism that may contribute to ALS.

Exposure to Formaldehyde May Raise ALS Risk

Exposure to Formaldehyde May Raise ALS Risk

The researchers stressed that the results do not indicate a cause-and-effect link between formaldehyde exposure and ALS.

High Levels of Vitamin D May Affect ALS Prognosis

High Levels of Vitamin D May Affect ALS Prognosis

The findings of this study were at odds with previous findings.

Type 2 Diabetes May Protect Against ALS, Especially in Old Age

Type 2 Diabetes May Protect Against ALS, Especially in Old Age

The mechanism behind the link is still unknown.

Advances in Neuroimaging for Amyotrophic Lateral Sclerosis

Advances in Neuroimaging for Amyotrophic Lateral Sclerosis

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Neuroimaging could enable better classification of patients and provide information on affected brain regions.

Mouse Model Developed for Common Form of ALS, Frontotemporal Dementia

Mouse Model Developed for Common Form of ALS, Frontotemporal Dementia

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The mouse model will allow researchers to effectively test therapeutic compounds.

Debate Over Experimental ALS Drug Heats Up

Debate Over Experimental ALS Drug Heats Up

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Genervon has requested accelerated approval from the FDA for its experimental ALS drug, GM604.

Novel Technique Distinguishes Between ALS, Mimic Disorders

Novel Technique Distinguishes Between ALS, Mimic Disorders

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Threshold-tracking transcranial magnetic stimulation could be a useful diagnostic technique in the clinical setting.

Hypermethylation of C9orf72 Gene May Be Neuroprotective

Hypermethylation of C9orf72 Gene May Be Neuroprotective

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C9orf72 hypermethylation helps protect the brain against damage in ALS and frontotemporal degeneration.

Mechanism Behind Neuronal Death in Prion Diseases Identified

Mechanism Behind Neuronal Death in Prion Diseases Identified

Researchers are now working to identify compounds for new drug targets.

Study Identifies Mechanism that Causes Cell Death in ALS

Study Identifies Mechanism that Causes Cell Death in ALS

Researchers believe the finding has implications for other neurodegenerative diseases.

Vitamin D as a Neuroprotective Agent for Amyotrophic Lateral Sclerosis

Vitamin D as a Neuroprotective Agent for Amyotrophic Lateral Sclerosis

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Vitamin D deficiency is known to contribute to neurodegenerative diseases like dementia, however its connection to ALS is not yet well understood.

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