Amyotrophic Lateral Sclerosis

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

FDA Approves Tiglutik for the Treatment of Amyotrophic Lateral Sclerosis

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The FDA approval was supported by data from bioavailability studies comparing riluzole tablets and Tiglutik oral suspension.

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

Rasagiline Plus Riluzole is Safe, May Improve Survival in ALS

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Rasagiline was associated with a significant effect on survival within 6 months of treatment in an exploratory analysis.

Immunotherapy Promising for Slowing Progression of ALS

Immunotherapy Promising for Slowing Progression of ALS

A new immunotherapy appears to be well tolerated and possibly of benefit in patients with amyotrophic lateral sclerosis.

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

Linear Link for Physical Activity, Amyotrophic Lateral Sclerosis

There is a linear correlation for physical activity with amyotrophic lateral sclerosis.

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

MAPT H1 Haplotype Implicated in ALS Risk, With Genetic Overlap Between ALS and FTD

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Investigators sought to identify genetic factors that may contribute to the risk for neurodegenerative diseases, such as amyotrophic lateral sclerosis and frontotemporal dementia.

Sensory Cortex Hyperexcitability Predicts Shorter Survival in ALS

Sensory Cortex Hyperexcitability Predicts Shorter Survival in ALS

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Investigators assessed patients with sporadic ALS to determine the relationship between somatosensory cortex excitability and survival prognosis.

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Occupational Exposure to Diesel Exhaust Tied to ALS Risk

Researchers found that for men with any occupational exposure to diesel exhaust, the odds ratio for amyotrophic lateral sclerosis increased with increasing lag periods.

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

Pseudobulbar Affect Linked to Mood Symptoms in Parkinsonian Syndromes

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Pseudobulbar affect is characterized by episodes of inappropriate laughing or crying, and may be associated with increased anxiety and depression, as well as lower mental health status.

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

Riluzole Prolongs Survival in Late-Stage Amyotrophic Lateral Sclerosis

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Patients who received 100 mg/day riluzole spent significantly more time in stage 4 than patients who were randomly assigned to placebo.

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

Evidence of Impaired Glucose Signaling in Amyotrophic Lateral Sclerosis

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Further research is warranted to clarify the role played by insulin resistance in the pathogenesis of amyotrophic lateral sclerosis.

Prevalence of ALS Remains Steady in US

Prevalence of ALS Remains Steady in US

The prevalence of ALS in the United States has been steady.

Arimoclomol Shows Promise for Treating Rapidly Progressive <i>SOD1</i> ALS

Arimoclomol Shows Promise for Treating Rapidly Progressive SOD1 ALS

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Due to the rarity of rapidly progressive SOD1 ALS, this study had a small sample size and may be limited in power.

Shortcomings in ALS Research: Strategies for Improvement

Shortcomings in ALS Research: Strategies for Improvement

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Researchers recently identified 5 key challenges that collectively hinder the design of amyotrophic lateral sclerosis clinical trials and the development of new treatments.

New Amyotrophic Lateral Sclerosis Tx Approved by FDA

New Amyotrophic Lateral Sclerosis Tx Approved by FDA

Radicava is the first approved treatment for ALS in over 20 years.

ALS Prognosis Better Predicted With Addition of MRI Measures

ALS Prognosis Better Predicted With Addition of MRI Measures

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More accurate prediction of ALS prognosis can allow for better planned palliative care.

Preclinical Pain in Amyotrophic Lateral Sclerosis May Be a Marker for Diagnosis, Treatment

Preclinical Pain in Amyotrophic Lateral Sclerosis May Be a Marker for Diagnosis, Treatment

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Reports of pain may indicate a preclinical course of amyotrophic lateral sclerosis.

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

Meditation May Benefit Anxiety, Depression in Amyotrophic Lateral Sclerosis

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Mindfulness meditation was associated with improvements in measures of anxiety, depression, and negative thoughts.

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