Adverse events, including voluntary psychiatric admission, suicide attempt, serious violent incident, voluntary admission to a general medical ward, overdose of medication or painkillers, were highest among the combined group compared to the monotherapies.
Despite being common and often comorbid neurodevelopmental disorders, the study found robust yet subtle differences across age groups and the disorders in terms of cortical and subcortical brain structures.
A third of patients presented with an altered mental state, including 9 patients with unspecified encephalopathy, 7 with encephalitis, and 23 fulfilling the clinical definition for psychiatric diagnoses.
The researchers concluded that the correlation between interregional cortical thinning during maturation and expression patterns of genes associated with multiple psychiatric disorders suggested a common molecular process.
Detection of left ventricular hypertrophy with electrocardiographic Sokolow-Lyon or Cornell voltage criteria was found to predict stroke and improve risk stratification among patients with hypertension.
