Sickle cell anemia
Sickle-cell Anemia 1. Clinical Decision Support Digital Program for Obstetrics Pathophysiology The sickle hemoglobin molecule is a result of a gene mutation that substitutes a valine for glutamic acid at the sixth position in the hemoglobin beta-subunit rendering the molecule less stable than the Hgb A structure. In the presence of hypoxia, infection, dehydration and…