Sheila Jacobs

Contributing Writer https://www.neurologyadvisor.com

Sheila Jacobs is the president of STJ Editorial Services. For more than 25 years, Sheila has been providing writing, fact-checking, and editorial services to numerous clients in the medical education, promotional, and managed care arenas, from the conceptual stage through completion of the final editorial product. Her focus has been in a diverse array of therapeutic areas.

All articles by Sheila Jacobs

Neurobehavioral Disorders

Gamma Transcranial Alternating Current Stimulation and Mood, Cognition in Major Depressive Disorder

Sheila Jacobs

October 1, 2020

Patients received 40 Hz gamma tACS to provide data on the use of varying stimulation periods.

OSA obstructive sleep apnea illustration

Uncategorized

OSA Severity Reduced in Type 2 Diabetes With Lifestyle Interventions for Weight Loss

Sheila Jacobs

August 28, 2020

The use of intensive lifestyle intervention for weight loss in patients with type 2 diabetes has been shown to reduce the overall severity of obstructive sleep apnea.

businessman yawning on train, sleepiness, tired, OSA

Sleep Disorders

Pitolisant Reduces Daytime Sleepiness in Patients Nonadherent to CPAP

Sheila Jacobs

February 5, 2020

In patients with obstructive sleep apnea who refuse or are nonadherent to continuous positive airway pressure therapy, pitolisant may reduce self-reported excessive daytime sleepiness.

Headache Migraine Advisor

Distinct Gender Differences Noted Among Individuals With Cluster Headache

Sheila Jacobs

December 27, 2019

Investigators have found data that show there is phenotypical similarity between cluster headache and migraine in women.

Headache Migraine Advisor

Cortical GABA Levels in Patients Experiencing Migraine With Aura

Sheila Jacobs

December 26, 2019

Investigators found data that showed in patients with less severe migraine, levels of GABA were unchanged.

Headache Migraine Advisor

Is Dexketoprofen Beneficial for Patients Who Experience Migraine Attacks?

Sheila Jacobs

December 23, 2019

Dexketoprofen supplementation can enhance pain control at 48 hours and reduce the need for a rescue drug in patients with migraine attacks.

World Sleep 2019

Longer Sleep Duration in OSA Linked to Higher Coronary Artery Calcium Scores

Sheila Jacobs

October 25, 2019

The interaction between obstructive sleep apnea and long sleep duration was associated with a nearly 3-fold chance of having a coronary artery calcium score of >100.

World Sleep 2019

Obstructive Sleep Apnea Symptom Subtypes Identified Using Novel Algorithm

Sheila Jacobs

October 16, 2019

A simple, efficient algorithm has been developed that will help to classify symptom subtypes among patients with obstructive sleep apnea based on only 6 symptom items.

For preschool-aged children, the American Academy of Pediatrics (AAP) recommends that clinicians prescribe evidence-based parent- and/or teacher-administered behavior therapy as first-line ADHD treatment. If evidence-based behavioral treatments are not available, clinicians should weigh the risks of starting medication at an early age against the harm of delaying diagnosis and treatment.

Headache Migraine Advisor

Clinical Practice Guidelines on Migraine Treatment in Children, Adolescents

Sheila Jacobs

October 1, 2019

Recommendations for the pharmacologic treatment of acute migraine in children and adolescents focus on the following: (1) the importance of early treatment; (2) selecting the route of administration that is best suited to the features of a particular migraine attack; (3) offering counseling on lifestyle factors that can exacerbate migraine attacks, including avoidance of triggers…

Inflammatory mediators that sensitize primary afferent nociceptors are increased during migraine. Likely as a result of neurogenic meningeal inflammation, dural mast cells, macrophages, and other immune cells release proinflammatory mediators known to sensitize meningeal nociceptors, such as 5-HT, histamine, prostaglandins, and cytokines.29 In addition to neuronal receptors, non-neuronal cell types may also be involved in the sensitizing actions of inflammatory cytokines. For example, it has been found that “local application of TNF-α to the meninges evokes TNF receptor-mediated activation of p38 MAP kinase in dural blood vessels, and that the p38 antagonist SB203580 inhibits TNF-α-mediated meningeal afferent sensitization,” and additional factors released by endothelial cells, such as endothelin-1 (ET-1) and c-type natriuretic peptide (CNP), may also contribute to meningeal afferent sensitization.30

Headache Migraine Advisor

Revisiting the Role of Histamines in Migraine

Sheila Jacobs

May 15, 2019

Researchers found that first-generation antihistamines are ineffective in preventing migraine, but that there is the potential for H3 agonists to treat migraine.

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