Sheila Jacobs

Contributing Writer https://www.neurologyadvisor.com

Sheila Jacobs is the president of STJ Editorial Services. For more than 25 years, Sheila has been providing writing, fact-checking, and editorial services to numerous clients in the medical education, promotional, and managed care arenas, from the conceptual stage through completion of the final editorial product. Her focus has been in a diverse array of therapeutic areas.

All articles by Sheila Jacobs

World Sleep 2019

Longer Sleep Duration in OSA Linked to Higher Coronary Artery Calcium Scores

Sheila Jacobs

October 25, 2019

The interaction between obstructive sleep apnea and long sleep duration was associated with a nearly 3-fold chance of having a coronary artery calcium score of >100.

World Sleep 2019

Obstructive Sleep Apnea Symptom Subtypes Identified Using Novel Algorithm

Sheila Jacobs

October 16, 2019

A simple, efficient algorithm has been developed that will help to classify symptom subtypes among patients with obstructive sleep apnea based on only 6 symptom items.

For preschool-aged children, the American Academy of Pediatrics (AAP) recommends that clinicians prescribe evidence-based parent- and/or teacher-administered behavior therapy as first-line ADHD treatment. If evidence-based behavioral treatments are not available, clinicians should weigh the risks of starting medication at an early age against the harm of delaying diagnosis and treatment.

Headache Migraine Advisor

Clinical Practice Guidelines on Migraine Treatment in Children, Adolescents

Sheila Jacobs

October 1, 2019

Recommendations for the pharmacologic treatment of acute migraine in children and adolescents focus on the following: (1) the importance of early treatment; (2) selecting the route of administration that is best suited to the features of a particular migraine attack; (3) offering counseling on lifestyle factors that can exacerbate migraine attacks, including avoidance of triggers…

Inflammatory mediators that sensitize primary afferent nociceptors are increased during migraine. Likely as a result of neurogenic meningeal inflammation, dural mast cells, macrophages, and other immune cells release proinflammatory mediators known to sensitize meningeal nociceptors, such as 5-HT, histamine, prostaglandins, and cytokines.29 In addition to neuronal receptors, non-neuronal cell types may also be involved in the sensitizing actions of inflammatory cytokines. For example, it has been found that “local application of TNF-α to the meninges evokes TNF receptor-mediated activation of p38 MAP kinase in dural blood vessels, and that the p38 antagonist SB203580 inhibits TNF-α-mediated meningeal afferent sensitization,” and additional factors released by endothelial cells, such as endothelin-1 (ET-1) and c-type natriuretic peptide (CNP), may also contribute to meningeal afferent sensitization.30

Headache Migraine Advisor

Revisiting the Role of Histamines in Migraine

Sheila Jacobs

May 15, 2019

Researchers found that first-generation antihistamines are ineffective in preventing migraine, but that there is the potential for H3 agonists to treat migraine.

boy holding toy behind his back parents fight

Headache Migraine Advisor

Childhood Traumas, Stress Affect Outcomes of Detox Therapy for Chronic Migraine

Sheila Jacobs

May 8, 2019

Investigators found data that show that emotional childhood traumas are linked to prolonged medication overuse.

Stroke

Diabetes May Be a Risk Factor for Stroke in Women With Gout

Sheila Jacobs

April 19, 2019

Assessment and management of comorbidities of gout can reduce future stroke risk in female patients.

Stroke

Comparative Efficacy of Clopidogrel vs Prasugrel in Noncardioembolic Ischemic Stroke

Sheila Jacobs

March 14, 2019

A large phase 3 trial compared prasugrel (3.75 mg/day) with clopidogrel (75 mg/day) for secondary stroke prevention in patients with noncardioembolic stroke.

Migraine and Headache

Few Patients Discharged From ED With Nonspecific Headache Are Readmitted With Serious Condition

Sheila Jacobs

March 13, 2019

Few patients who were discharged from the emergency department with a nonspecific diagnosis of headache or back pain were readmitted for a serious neurologic condition or died as inpatients within 30 days of the initial visit.

General Neurology

Witness Observations Valuable for the Diagnosis of Transient Loss of Consciousness

Sheila Jacobs

March 12, 2019

A comprehensive profile of witness-observable transient loss of consciousness manifestations can make an important contribution to differentiation between epilepsy, syncope, and psychogenic nonepileptic seizures.

Migraine and Headache

Late Onset of Migraine With Aura Linked to Increased Stroke Risk in Late Life

Sheila Jacobs

March 8, 2019

The study underscores the importance of migraine with aura symptom onset in the evaluation of ischemic stroke risk in late life.

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