White matter integrity plays an important part in the neural signature of cognitive impairment in early onset epilepsy.
fMRI-DES could be used for full-brain volume evaluation of brain connectivity and help lead to the refinement of laser ablative procedures for epilepsy.
DICAM was strongly linked with expression of ROR-γ, IL-23R, IL-17, IL-22, GM-CSF, and GZMB expression in human CD4+ lymphocytes.
The additional measure of brain volume loss results in a more comprehensive evaluation of disease activity in RRMS.
The ratio was also predictive of conversion to secondary-progressive MS.
CSF NfL levels were predictive of brain volume loss at first sign of MS and follow-up.
Spinal cord gray matter atrophy was found to be most relevant compared to other conventional MRI metrics.
Compared to RRMS, progressive MS had greater cord atrophy and lesions.
No significant treatment effect on disease progression or brain or cervical spinal atrophy was observed.