Fluorescence Can ID High-Grade Glioma During Sx for Brain Tumor

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The presence of visible fluorescence can serve as an intraoperative diagnostic surgical biomarker of high-grade glioma within a brain tumor.
The presence of visible fluorescence can serve as an intraoperative diagnostic surgical biomarker of high-grade glioma within a brain tumor.

HealthDay News — The presence of visible fluorescence can serve as an intraoperative diagnostic surgical biomarker of high-grade glioma within a brain tumor, according to a study presented at the 2018 National Cancer Research Institute Cancer Conference, held from Nov. 4 to 6 in Glasgow, Scotland.

Colin Watts, M.B.B.S., Ph.D., from the University of Birmingham in the United Kingdom, and colleagues assessed whether visible fluorescence 5-aminolevulinic acid is a pragmatic intraoperative diagnostic surgical biomarker of high-grade disease within a tumor mass in real time during surgery. Among the sample of 103 patients (median age, 59 years; 59 percent male), the authors compared the presence of visible fluorescence to histopathological analysis.

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The researchers note that of the 88 patients who were evaluable, 81 had visible fluorescence of the tumor. Central histopathology diagnosis included one low-grade glioma, 78 high-grade gliomas (a 99 percent concordance), and two not assessed. Seven patients had no visible fluorescence, and of these patients, six were diagnosed with low-grade gliomas and one with a high-grade glioma.

"The advantage of this technique is that it may highlight more quickly high-grade disease within a tumor during neurosurgery," Watts said in a statement. "What this means is that more of the tumor can be removed more safely and with fewer complications, and that's better for the patient."

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