Brain Tumors

Nivolumab + Ipilimumab Shows Efficacy for Untreated Brain Mets

Nivolumab + Ipilimumab Shows Efficacy for Untreated Brain Mets

For patients with melanoma and untreated brain metastases, nivolumab combined with ipilimumab shows clinically meaningful efficacy.

Modified Polio Vaccine Looks Promising in Early Glioblastoma Trial

Modified Polio Vaccine Looks Promising in Early Glioblastoma Trial

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PVSRIPO is a prototypic oncolytic recombinant polio virus vaccine that recognizes the poliovirus receptor CD155, which is widely expressed in neoplastic cells of solid tumors.

Child Neuroblastoma Survivors at Risk for Psych Impairment

Child Neuroblastoma Survivors at Risk for Psych Impairment

Neuroblastoma survivors are at elevated risk for psychological impairment.

Quality of Life in Glioblastoma Not Worsened by Tumor-Treating Fields Plus Temozolomide

Quality of Life in Glioblastoma Not Worsened by Tumor-Treating Fields Plus Temozolomide

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Participants receiving TTFields with temozolomide experienced significantly longer deterioration-free survival for global health vs those receiving temozolomide only.

Clinical Factors Associated With Pediatric Brain Neoplasms

Clinical Factors Associated With Pediatric Brain Neoplasms

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A study pinpointed clinical factors associated with pediatric brain neoplasms to assist clinicians in making neuroimaging decisions.

No Survival Benefit With Lomustine Plus Bevacizumab in Glioblastoma

No Survival Benefit With Lomustine Plus Bevacizumab in Glioblastoma

Treatment with lomustine plus bevacizumab does not show a survival advantage over treatment with lomustine alone in patients with glioblastoma.

Temozolomide Plus Radiotherapy Improves Survival in Non-Co-Deleted Glioma

Temozolomide Plus Radiotherapy Improves Survival in Non-Co-Deleted Glioma

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1p/19q non-co-deleted anaplastic gliomas are associated with lower sensitivity to chemotherapy and worse prognosis than 1p/19q co-deleted tumors.

Increased Survival For Melanoma Brain Metastases

Increased Survival For Melanoma Brain Metastases

In patients with melanoma brain metastases, overall survival has increased since 2000.

Postoperative Stereotactic Radiosurgery Reduces Recurrence After Metastases Resection

Postoperative Stereotactic Radiosurgery Reduces Recurrence After Metastases Resection

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The use of postoperative stereotactic radiosurgery could be a substitute for whole-brain radiotherapy, which has been linked to cognitive adverse effects.

Glioblastoma Treatment May Benefit From Vaccine-Chemotherapy Combo

Glioblastoma Treatment May Benefit From Vaccine-Chemotherapy Combo

Nearly half of the patients in the trial survived more than 5 years after they were given the vaccine-chemotherapy treatment.

Researchers Debunk Rumored Link Between Glioblastoma, Cytomegalovirus

Researchers Debunk Rumored Link Between Glioblastoma, Cytomegalovirus

Despite previous reports, researchers have found no signs of a link between cytomegalovirus and brain tumors including glioblastoma.

HER2-Negative Breast Cancer Turns Positive in the Brain

HER2-Negative Breast Cancer Turns Positive in the Brain

Molecular changes occur to cancer cells when they spread to the brain.

Radiomic Method Helps Predicts Glioblastoma Outcome

Radiomic Method Helps Predicts Glioblastoma Outcome

Radiomic-based superpc signature stratifies patients into low- or high-risk groups for PFS, OS.

Increasing PORT Deferral in Medulloblastoma Raises Mortality Risk

Increasing PORT Deferral in Medulloblastoma Raises Mortality Risk

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Despite it being a standard of care, more or more pediatric patients are deferring PORT.

Stereotactic Radiosurgery Alone Better for Cognition in Brain Metastases

Stereotactic Radiosurgery Alone Better for Cognition in Brain Metastases

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Intracranial disease control at 3 months was better with combination therapy; however it did not appear to impact overall survival.

Total Resection Improves Survival in Glioblastoma Multiforme

Total Resection Improves Survival in Glioblastoma Multiforme

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GTR increases survival by about 61% at 1 year compared to STR.

Double Autologous Stem Cell Transplants Boost Survival in Neuroblastoma

Double Autologous Stem Cell Transplants Boost Survival in Neuroblastoma

Researchers achieved a 3-year event-free survival rate of 73.2% for tandem transplant patients.

In Glioblastoma, Personalized Medicine is a Challenge

In Glioblastoma, Personalized Medicine is a Challenge

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The role of antiangiogenic agents continues to evolve in the treatment of CNS cancers.

Glioma Signature Predicts Outcomes in Glioblastoma

Glioma Signature Predicts Outcomes in Glioblastoma

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Researchers were able to identify 8 genes that showed the highest association to outcomes.

Combined Modality Therapy Superior in Glioblastoma

Combined Modality Therapy Superior in Glioblastoma

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Multiple modalities were found to be superior to single modality therapies in elderly patients with glioblastoma.

Valproic Acid Beneficial in Glioblastoma, But Not Low-Grade Glioma

Valproic Acid Beneficial in Glioblastoma, But Not Low-Grade Glioma

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Interestingly, the risk of death and tumor progression was increased in low-grade gliomas.

Chemo Plus Radiation May Extend Survival in Grade 2 Glioma

Chemo Plus Radiation May Extend Survival in Grade 2 Glioma

Those who received both treatments lived longer than those who received radiation alone.

Brain Cooling Technique Helps Protect, Identify Speech Regions During Surgery

Brain Cooling Technique Helps Protect, Identify Speech Regions During Surgery

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Focal cooling is a vast improvement over older brain-mapping techniques, which risked triggering epileptic seizures during surgery.

Brain Tumor Histology and Incidence in Adolescents and Young Adults

Brain Tumor Histology and Incidence in Adolescents and Young Adults

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Over 10 000 brain and CNS tumors are diagnosed in adolescent and young adults each year.

Proton Radiotherapy May Be Feasible Option for Pediatric Brain Tumor

Proton Radiotherapy May Be Feasible Option for Pediatric Brain Tumor

Proton radiotherapy showed acceptable toxicity and similar survival compared to conventional radiotherapy.

Does Rosacea Increase the Risk of Glioma?

Does Rosacea Increase the Risk of Glioma?

The association may be mediated by mechanisms dependent on matrix metalloproteinases.

Bioresorbable Implant May Monitor Brain During Surgery

Bioresorbable Implant May Monitor Brain During Surgery

The device is designed to measure pressure and temperature during and after surgery, and then dissolve. Human trials are still at least 3 to 4 years away, however.

Electromagnetic Field Therapy Promising for Glioblastoma Treatment

Electromagnetic Field Therapy Promising for Glioblastoma Treatment

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Two years post-enrollment, 43% of patients in the combination therapy group were alive.

VIDEO: Global Coalition to Design Adaptive Clinical Trial for Glioblastoma

VIDEO: Global Coalition to Design Adaptive Clinical Trial for Glioblastoma

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The adaptive trial design will allow GBM patients to benefit from precision medicine.

DNA From Cerebrospinal Fluid May Effectively Monitor Brain Metastases

DNA From Cerebrospinal Fluid May Effectively Monitor Brain Metastases

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Researchers found that brain tumor mutations could be detected from ctDNA in cerebrospinal fluid.

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