Generic Name and Formulations:
Cladribine 1mg/mL; soln for IV infusion after dilution; preservative-free.
Various generic manufacturers
Indications for Cladribine:
Active hairy cell leukemia.
Give by continuous IV infusion for 7 consecutive days. 0.09mg/kg per day.
See full labeling.
Administer under the supervision of a qualified physician experienced in the use of antineoplastic therapy. Risk of neurological toxicity. Acute nephrotoxicity has been observed with high doses (esp. when concomitant with other nephrotoxic treatments).
Delay or discontinue if neurotoxicity or renal toxicity occurs. Myelosuppression. Active infection. Renal or hepatic insufficiency. Monitor blood counts (esp. during first 4–8 weeks post-dose), renal and hepatic function. Pregnancy (Cat.D), nursing mothers: not recommended.
Chlorinated purine nucleoside analog.
Live attenuated vaccines: not recommended. Increased toxicity with myelosuppressive, immunosuppressive, or nephrotoxic agents.
Severe myelosuppression (eg, neutropenia, anemia, thrombocytopenia), fever, infection, fatigue, nausea, rash, headache, inj site reactions, others; neurotoxicity, nephrotoxicity, tumor lysis syndrome (rare).
Neurology Advisor Articles
- Some Statins May Be Associated With Cognition, Memory Deficits
- Neuropathic Pain Treatments
- Cannabis for Multiple Sclerosis: Prescriber's Perspective
- New Monoclonal Antibody BAN2401 Reduces Amyloid Plaques, Improves Cognition in Alzheimer's
- Nonpharmacologic Interventions for Alzheimer's Have Greater Impact on Outcomes Than Currently Available Medications
- OnabotulinumtoxinA for Post-Stroke Spasticity: Treatment Strategies and Limitations
- Tau Associated With Loss of Anterior Temporal White Matter Integrity
- Location Probability Learning Unimpaired in Parkinson Disease
- Prenatal Tdap Vaccination Not Linked to Autism Risk
- AMA Adopts Policy to Advance Gender Equity in Medicine