Certain Comorbidities More Common in People With Multiple Sclerosis

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Individuals with MS showed statistically higher rates of anxiety, gastrointestinal disease, hypertension, depression, hyperlipidemia, and thyroid disease compared to those without MS.
Individuals with MS showed statistically higher rates of anxiety, gastrointestinal disease, hypertension, depression, hyperlipidemia, and thyroid disease compared to those without MS.
The following article is part of conference coverage from the 2018 Annual Meeting of the Consortium of Multiple Sclerosis Centers in Nashville, Tennesssee. Neurology Advisor's staff will be reporting breaking news associated with research conducted by leading experts in neurology. Check back for the latest news from CMSC 2018.

Certain comorbidities are more prevalent in people with multiple sclerosis (MS) than without, an effect that varies by sex and age group. This research was presented at the 32nd Annual Meeting of the Consortium of Multiple Sclerosis Centers, held May 30-June 2, 2018, in Nashville, Tennessee.

The study researchers examined data from the US database of the IMS Health Real World Data Adjudicated Claims between 2011 and 2015. They included subjects with at least 2 claims of MS in any of the database's diagnosis fields. Subjects were classified according to their sex and age (18 to 24, 25 to 34, 35 to 44, 45 to 54, and 55 to 65 years) in the first analysis, after which the rate of common comorbid conditions in MS were examined.

The study researchers compared rates of prevalence between subjects according to MS status, sex, and age group using exact matching to match those with MS with those without MS in each group. Factors in exact matching included geographic area, index-year quarter, and age.

In this retrospective, administrative claims database analysis, individuals with MS showed statistically higher rates of anxiety, gastrointestinal disease, hypertension, depression, hyperlipidemia, and thyroid disease than those without MS across every age group (P <.0001). People with MS also had significantly higher rates of chronic lung disease, diabetes, and arthritis than those without MS in all age groups (P <.0001), except between 55 and 65 years old.

Both men and women with MS showed significantly higher rates of arthritis, chronic lung disease, gastrointestinal disease, hypertension, thyroid disease, anxiety, depression, and hyperlipidemia than those without MS (P <.001). Diabetes did not show differential prevalence in people with MS and those without in men or women (P >.05).

The study researchers concluded that “[rates] of several comorbidities differed in patients with MS compared with those without MS within various age groups and by sex. Some of these differences were not present in the oldest age group. The reasons for this finding are not yet understood.”

For more coverage of CMSC 2018, click here.

Reference

Kresa-Reahl K, Edwards NC, Phillips AL. Prevalence of comorbidities in patients with and without multiple sclerosis by age and sex: a US retrospective claims database analysis. Poster presentation at: 2018 CMSC Annual Meeting. May 30-June 2, 2018; Nashville, TN. Abstract EG04.

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